Details:

Alternative Title:
Prev Chronic Dis
Personal Author:
Kompaniyets, Lyudmyla ; Pennington, Audrey F. ; Goodman, Alyson B. ; Rosenblum, Hannah G. ; Belay, Brook ; ... More +
Kompaniyets, Lyudmyla ; Pennington, Audrey F. ; Goodman, Alyson B. ; Rosenblum, Hannah G. ; Belay, Brook ; Ko, Jean Y. ; Chevinsky, Jennifer R. ; Schieber, Lyna Z. ; Summers, April D. ; Lavery, Amy M. ; Preston, Leigh Ellyn ; Danielson, Melissa L. ; Cui, Zhaohui ; Namulanda, Gonza ; Yusuf, Hussain ; Mac Kenzie, William R. ; Wong, Karen K. ; Baggs, James ; Boehmer, Tegan K. ; Gundlapalli, Adi V. Less -
Description:
Introduction

Severe COVID-19 illness in adults has been linked to underlying medical conditions. This study identified frequent underlying conditions and their attributable risk of severe COVID-19 illness.

Methods

We used data from more than 800 US hospitals in the Premier Healthcare Database Special COVID-19 Release (PHD-SR) to describe hospitalized patients aged 18 years or older with COVID-19 from March 2020 through March 2021. We used multivariable generalized linear models to estimate adjusted risk of intensive care unit admission, invasive mechanical ventilation, and death associated with frequent conditions and total number of conditions.

Results

Among 4,899,447 hospitalized adults in PHD-SR, 540,667 (11.0%) were patients with COVID-19, of whom 94.9% had at least 1 underlying medical condition. Essential hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%) were the most common. The strongest risk factors for death were obesity (adjusted risk ratio [aRR] = 1.30; 95% CI, 1.27–1.33), anxiety and fear-related disorders (aRR = 1.28; 95% CI, 1.25–1.31), and diabetes with complication (aRR = 1.26; 95% CI, 1.24–1.28), as well as the total number of conditions, with aRRs of death ranging from 1.53 (95% CI, 1.41–1.67) for patients with 1 condition to 3.82 (95% CI, 3.45–4.23) for patients with more than 10 conditions (compared with patients with no conditions).

Conclusion

Certain underlying conditions and the number of conditions were associated with severe COVID-19 illness. Hypertension and disorders of lipid metabolism were the most frequent, whereas obesity, diabetes with complication, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. Careful evaluation and management of underlying conditions among patients with COVID-19 can help stratify risk for severe illness.


Subjects:
[+]
Aged Age Factors Comorbidity Coronavirus Infections COVID-19 Diabetes Complications Female Hospitalization Humans Male Mortality Multimorbidity Noncommunicable Diseases Obesity Phobic Disorders Risk Assessment Risk Factors SARS-CoV-2 Severity Of Illness Index
Source:
Prev Chronic Dis. 2021; 18
Pubmed ID:
34197283
Pubmed Central ID:
PMC8269743
Document Type:
Journal Article
Place as Subject:
United States
Location:
North America
Collection(s):
Preventing Chronic Disease
Main Document Checksum:
[+]
urn:sha256:d93f436de9092d0d77c87d639b809a02cbdb6ca4fe3986a045cc14f4b3256c2e
Download URL:
https://stacks.cdc.gov/view/cdc/108362/cdc_108362_DS1.pdf
File Type:

Supporting Files

• 	PCD-18-E66.nxml	xml
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  	PCD-18-E66s01.jpg	jpeg
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