Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Clark, Carla M. ; Driver, Cynthia R. ; Munsiff, Sonal S. ; Driscoll, Jeffrey R. ; Kreiswirth, Barry N. ; ... More +
Clark, Carla M. ; Driver, Cynthia R. ; Munsiff, Sonal S. ; Driscoll, Jeffrey R. ; Kreiswirth, Barry N. ; Zhao, Benyang ; Ebrahimzadeh, Adeleh ; Salfinger, Max ; Piatek, Amy S. ; Abdelwahab, Jalaa' Less -
Corporate Authors:
New York City Molecular Epidemiology Working Group
Description:
In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.
Subject:
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Bacterial Typing Techniques
Cluster Analysis
Cross Infection
False Positive Reactions
Genotype
Humans
Mycobacterium Tuberculosis
Perspective
Polymorphism, Restriction Fragment Length
Tuberculosis
Tuberculosis, Multidrug-Resistant

Source:
Emerg Infect Dis. 12(5):719-724.
Document Type:
Journal Article
Place as Subject:
New York City, NY
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:260e86055e0ecddc6b37df5384ce89fe5f934ee033146785d0bb4807c137793b
File Type:

Supporting Files

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