Universal Genotyping in Tuberculosis Control Program, New York City, 2001–2003

Clark, Carla M.; Driver, Cynthia R.; Munsiff, Sonal S.; Driscoll, Jeffrey R.; Kreiswirth, Barry N.; Zhao, Benyang; Ebrahimzadeh, Adeleh; Salfinger, Max; Piatek, Amy S.; Abdelwahab, Jalaa'

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Universal Genotyping in Tuberculosis Control Program, New York City, 2001–2003

Published Date:

May 2006

Source:

Emerg Infect Dis. 12(5):719-724.

Language:

English

[PDF-128.65 KB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Clark, Carla M. ; Driver, Cynthia R. ; Munsiff, Sonal S. ; Driscoll, Jeffrey R. ; Kreiswirth, Barry N. ; ... More ▼

Corporate Authors:

New York City Molecular Epidemiology Working Group

Description:

In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping to type isolates from culture-positive TB patients. Results are used to identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, and potential false-positive cultures. From 2001 to 2003, spoligotype and IS6110-based RFLP results were obtained for 90.7% of eligible and 93.7% of submitted isolates. Fifty-nine (2.4%) of 2,437 patient isolates had false-positive culture results, and 205 genotype clusters were identified, with 2-81 cases per cluster. Cluster investigations yielded 57 additional links and 17 additional sites of transmission. Four additional TB cases were identified as a result of case finding initiated through cluster investigations. Length of unnecessary treatment decreased among patients with false-positive cultures.

Subject:

[+]

Document Type:

Journal Article

Place as Subject:

New York City, NY

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

Supporting Files:

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