Novel Morbillivirus as Putative Cause of Fetal Death and Encephalitis among Swine

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Arruda, Bailey ; Shen, Huigang ; Zheng, Ying ; Li, Ganwu
• Description:
  Morbilliviruses are highly contagious pathogens. The Morbillivirus genus includes measles virus, canine distemper virus (CDV), phocine distemper virus (PDV), peste des petits ruminants virus, rinderpest virus, and feline morbillivirus. We detected a novel porcine morbillivirus (PoMV) as a putative cause of fetal death, encephalitis, and placentitis among swine by using histopathology, metagenomic sequencing, and in situ hybridization. Phylogenetic analyses showed PoMV is most closely related to CDV (62.9% nt identities) and PDV (62.8% nt identities). We observed intranuclear inclusions in neurons and glial cells of swine fetuses with encephalitis. Cellular tropism is similar to other morbilliviruses, and PoMV viral RNA was detected in neurons, respiratory epithelium, and lymphocytes. This study provides fundamental knowledge concerning the pathology, genome composition, transmission, and cellular tropism of a novel pathogen within the genus Morbillivirus and opens the door to a new, applicable disease model to drive research forward.
• Subjects:
  Animals Distemper Virus, Canine Encephalitis Fetal Death Morbillivirus Phylogeny Swine
• Source:
  Emerg Infect Dis. 27(7):1858-1866
• Pubmed ID:
  34152961
• Pubmed Central ID:
  PMC8237871
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:20cbe5b76d65df7905536e3bd53cef581784b2193953b4499237d0c77a58932d
• Download URL:
  https://stacks.cdc.gov/view/cdc/107957/cdc_107957_DS1.pdf
• File Type:
  [PDF - 2.59 MB ]