Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru1

Morales, Maria L.; Tanabe, Melinda B.; White, A. Clinton; Lopez, Martha; Bascope, Ruben; Cabada, Miguel M.

i

Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School-Age Children, Cusco, Peru1

Supporting Files

July 2021
By Morales, Maria L. ; Tanabe, Melinda B. ; White, A. Clinton ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Morales, Maria L. ; Tanabe, Melinda B. ; White, A. Clinton ; Lopez, Martha ; Bascope, Ruben ; Cabada, Miguel M.
Description:

We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1-4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean ± SD age was 10.4 ± 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed.
Subjects:

Adolescent Animals Anthelmintics Child Child, Preschool Fasciola Hepatica Fascioliasis Feces Female Humans Retrospective Studies Schools Treatment Failure Triclabendazole
Source:

Emerg Infect Dis. 27(7):1850-1857
Pubmed ID:

34152949
Pubmed Central ID:

PMC8237897
Document Type:

Journal Article
Funding:

R01 AI104820/AI/NIAID NIH HHSUnited States/
Place as Subject:

Peru
Volume:

27
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2b131e26ac7b9794b9fcb04c5d061172f3c549124565beb28cf86da8aa7081f0
Download URL:

https://stacks.cdc.gov/view/cdc/107955/cdc_107955_DS1.pdf
File Type:

[PDF - 1.39 MB ]

File Language:

English

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