Plasmodium falciparum kelch13 Mutations, 9 Countries in Africa, 2014–2018

Schmedes, Sarah E.; Patel, Dhruviben; Dhal, Simran; Kelley, Julia; Svigel, Samaly S.; Dimbu, Pedro Rafael; Adeothy, Adicatou-Laï; Kahunu, Gauthier Mesia; Nkoli, Papy Mandoko; Beavogui, Abdoul Habib; Kariuki, Simon; Mathanga, Don P.; Koita, Ousmane; Ishengoma, Deus; Mohamad, Ally; Hawela, Moonga; Moriarty, Leah F.; Samuels, Aaron M.; Gutman, Julie; Plucinski, Mateusz M.; Udhayakumar, Venkatachalam; Zhou, Zhiyong; Lucchi, Naomi W.; Venkatesan, Meera; Halsey, Eric S.; Talundzic, Eldin

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Plasmodium falciparum kelch13 Mutations, 9 Countries in Africa, 2014–2018

Supporting Files

July 2021
By Schmedes, Sarah E. ; Patel, Dhruviben ; Dhal, Simran ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Schmedes, Sarah E. ; Patel, Dhruviben ; Dhal, Simran ; Kelley, Julia ; Svigel, Samaly S. ; Dimbu, Pedro Rafael ; Adeothy, Adicatou-Laï ; Kahunu, Gauthier Mesia ; Nkoli, Papy Mandoko ; Beavogui, Abdoul Habib ; Kariuki, Simon ; Mathanga, Don P. ; Koita, Ousmane ; Ishengoma, Deus ; Mohamad, Ally ; Hawela, Moonga ; Moriarty, Leah F. ; Samuels, Aaron M. ; Gutman, Julie ; Plucinski, Mateusz M. ; Udhayakumar, Venkatachalam ; Zhou, Zhiyong ; Lucchi, Naomi W. ; Venkatesan, Meera ; Halsey, Eric S. ; Talundzic, Eldin
Description:

The spread of drug resistance to antimalarial treatments poses a serious public health risk globally. To combat this risk, molecular surveillance of drug resistance is imperative. We report the prevalence of mutations in the Plasmodium falciparum kelch 13 propeller domain associated with partial artemisinin resistance, which we determined by using Sanger sequencing samples from patients enrolled in therapeutic efficacy studies from 9 sub-Saharan countries during 2014-2018. Of the 2,865 samples successfully sequenced before treatment (day of enrollment) and on the day of treatment failure, 29 (1.0%) samples contained 11 unique nonsynonymous mutations and 83 (2.9%) samples contained 27 unique synonymous mutations. Two samples from Kenya contained the S522C mutation, which has been associated with delayed parasite clearance; however, no samples contained validated or candidate artemisinin-resistance mutations.
Subjects:

Drug Resistance Humans Malaria, Falciparum Mutation Plasmodium Falciparum Protozoan Proteins
Source:

Emerg Infect Dis. 27(7):1902-1908
Pubmed ID:

34152946
Pubmed Central ID:

PMC8237877
Document Type:

Journal Article
Funding:

WT_/Wellcome TrustUnited Kingdom/ ; 107740/Z/15/Z/WT_/Wellcome TrustUnited Kingdom/
Place as Subject:

Kenya
Volume:

27
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:fa072df70c21db8c652debd3440dab7f6c0f5af1efc0a77edd4e75736e2a2ff0
Download URL:

https://stacks.cdc.gov/view/cdc/107950/cdc_107950_DS1.pdf
File Type:

[PDF - 1.45 MB ]

File Language:

English

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