Yellow Fever Outbreak, Imatong, Southern Sudan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Onyango, Clayton O. ; Ofula, Victor O. ; Sang, Rosemary C. ; Konongoi, Samson L. ; Sow, Abdourahmane ; De Cock, Kevin M. ; Tukei, Peter M. ; Okoth, Fredrick A. ; Swanepoel, Robert ; Burt, Felicity J. ; Waters, Norman C. ; Coldren, Rodney L.
• Description:
  In May 2003, the World Health Organization received reports about a possible outbreak of a hemorrhagic disease of unknown cause in the Imatong Mountains of southern Sudan. Laboratory investigations were conducted on 28 serum samples collected from patients in the Imatong region. Serum samples from 13 patients were positive for immunoglobulin M antibody to flavivirus, and serum samples from 5 patients were positive by reverse transcription-polymerase chain reaction with both the genus Flavivirus-reactive primers and yellow fever virus-specific primers. Nucleotide sequencing of the amplicons obtained with the genus Flavivirus oligonucleotide primers confirmed yellow fever virus as the etiologic agent. Isolation attempts in newborn mice and Vero cells from the samples yielded virus isolates from five patients. Rapid and accurate laboratory diagnosis enabled an interagency emergency task force to initiate a targeted vaccination campaign to control the outbreak.
• Subjects:
  Adolescent Adult Animals Animals, Newborn Antibodies, Viral Biological Assay Brain Cercopithecus Aethiops Child Child, Preschool Disease Outbreaks Female Humans Male Mice Middle Aged Research Reverse Transcriptase Polymerase Chain Reaction RNA, Viral Sequence Analysis, DNA Seroepidemiologic Studies Vero Cells Yellow Fever Yellow Fever Virus

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• Source:
  Emerg Infect Dis. 10(6):1064-1068.
• Document Type:
  Journal Article
• Place as Subject:
  Sudan
• Location:
  Africa
• Volume:
  10
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ce515b7ba5a504478f7dca4710ca63ab58532eb7b6bf4a7c71f3e27de70776ce
• Download URL:
  https://stacks.cdc.gov/view/cdc/10794/cdc_10794_DS1.pdf
• File Type:
  [PDF - 51.73 KB ]