Details:

Alternative Title:
Magn Reson Med
Personal Author:
Ma, Junjie ; Chen, Jun ; Reed, Galen D. ; Hackett, Edward P. ; Harrison, Crystal E. ; ... More +
Ma, Junjie ; Chen, Jun ; Reed, Galen D. ; Hackett, Edward P. ; Harrison, Crystal E. ; Ratnakar, James ; Schulte, Rolf F. ; Zaha, Vlad G. ; Malloy, Craig R. ; Park, Jae Mo ; Less -
Description:
Purpose: Noninvasive imaging with hyperpolarized pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as T2*s of the hyperpolarized signals is critical. This study is to measure in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and the products in rodents and humans. Methods: A dynamic 13C multi-echo spiral imaging sequence that acquires [13C]bicarbonate, [1-13C]lactate, and [1-13C]pyruvate images in an interleaved manner was implemented for a clinical 3T system. T2* of each metabolite was calculated from the multi-echo images by fitting the signal decay of each region of interest mono-exponentially. The performance of measuring T2* using the sequence was validated using a 13C phantom, then with rodents following a bolus injection of hyperpolarized [1-13C]pyruvate. In humans, T2* of each metabolite was calculated for left ventricle (LV), right ventricle (RV) and myocardium. Results: Cardiac T2*s of hyperpolarized [1-13C]pyruvate, [1-13C]lactate and [13C]bicarbonate in rodents were measured as 24.9 ± 5.0, 16.4 ± 4.7, and 16.9 ± 3.4 ms, respectively. In humans, T2* of [1-13C]pyruvate was 108.7 ± 22.6 ms in LV and 129.4 ± 8.9 ms in RV. T2* of [1-13C]lactate was 40.9 ± 8.3, 44.2 ± 5.5, and 43.7 ± 9.0 ms in LV, RV and myocardium, respectively. T2* of [13C]bicarbonate in myocardium was 64.4 ± 2.5 ms. The measurements were reproducible and consistent over time after the pyruvate injection. Conclusions: The proposed metabolite-selective multi-echo spiral imaging sequence reliably measures in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and products.
Subject:
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Article
Carbon Isotopes
Dynamic Nuclear Polarization
Heart
Hyperpolarized Pyruvate
Magnetic Resonance Imaging
Multi-echo Imaging
Phantoms, Imaging
Pyruvic Acid
T2*
Heart

Source:
Magn Reson Med. 86(3):1494-1504 ;
Pubmed ID:
33821504
Pubmed Central ID:
PMC8212421
Document Type:
Journal Article ;
Funding:
RP180404/Cancer Prevention and Research Institute of Texas/ ; S10 RR029119/RR/NCRR NIH HHS/United States ; UTD 1907789/UT Dallas Collaborative Biomedical Research Award/ ; S10 OD018468/OD/NIH HHS/United States ; P41 EB015908/EB/NIBIB NIH HHS/United States ; ... More +
RP180404/Cancer Prevention and Research Institute of Texas/ ; S10 RR029119/RR/NCRR NIH HHS/United States ; UTD 1907789/UT Dallas Collaborative Biomedical Research Award/ ; S10 OD018468/OD/NIH HHS/United States ; P41 EB015908/EB/NIBIB NIH HHS/United States ; The Texas Institute for Brain Injury and Repair/ ; R01 NS107409/NS/NINDS NIH HHS/United States ; S10 OD018468/CD/ODCDC CDC HHS/United States ; I-2009-20190330/The Welch Foundation/ ; P41 EB015908/EB/NIBIB NIH HHS/United States ; R01 NS107409/NS/NINDS NIH HHS/United States ; S10 OD018468/CD/ODCDC CDC HHS/United States ; S10 RR029119/RR/NCRR NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:64fb0114f3e93c225d3b93023d45893376a1ef489b2c29cedaa35efb61df6bff
File Type:

Supporting Files

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