Cardiac T2* Measurement of Hyperpolarized 13C Metabolites using Metabolite-Selective Multi-Echo Spiral Imaging

Details

• Alternative Title:
  Magn Reson Med
• Personal Author:
  Ma, Junjie ; Chen, Jun ; Reed, Galen D. ; Hackett, Edward P. ; Harrison, Crystal E. ; Ratnakar, James ; Schulte, Rolf F. ; Zaha, Vlad G. ; Malloy, Craig R. ; Park, Jae Mo
• Description:
  Purpose:
  
  Noninvasive imaging with hyperpolarized pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as T2*s of the hyperpolarized signals is critical. This study is to measure in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and the products in rodents and humans.
  
  Methods:
  
  A dynamic 13C multi-echo spiral imaging sequence that acquires [13C]bicarbonate, [1-13C]lactate, and [1-13C]pyruvate images in an interleaved manner was implemented for a clinical 3T system. T2* of each metabolite was calculated from the multi-echo images by fitting the signal decay of each region of interest mono-exponentially. The performance of measuring T2* using the sequence was validated using a 13C phantom, then with rodents following a bolus injection of hyperpolarized [1-13C]pyruvate. In humans, T2* of each metabolite was calculated for left ventricle (LV), right ventricle (RV) and myocardium.
  
  Results:
  
  Cardiac T2*s of hyperpolarized [1-13C]pyruvate, [1-13C]lactate and [13C]bicarbonate in rodents were measured as 24.9 ± 5.0, 16.4 ± 4.7, and 16.9 ± 3.4 ms, respectively. In humans, T2* of [1-13C]pyruvate was 108.7 ± 22.6 ms in LV and 129.4 ± 8.9 ms in RV. T2* of [1-13C]lactate was 40.9 ± 8.3, 44.2 ± 5.5, and 43.7 ± 9.0 ms in LV, RV and myocardium, respectively. T2* of [13C]bicarbonate in myocardium was 64.4 ± 2.5 ms. The measurements were reproducible and consistent over time after the pyruvate injection.
  
  Conclusions:
  
  The proposed metabolite-selective multi-echo spiral imaging sequence reliably measures in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and products.
  
  
• Subjects:
  Article Carbon Isotopes Dynamic Nuclear Polarization Heart Hyperpolarized Pyruvate Magnetic Resonance Imaging Multi-echo Imaging Phantoms, Imaging Pyruvic Acid T2*
• Source:
  Magn Reson Med. 86(3):1494-1504
• Pubmed ID:
  33821504
• Pubmed Central ID:
  PMC8212421
• Document Type:
  Journal Article
• Funding:
  RP180404/Cancer Prevention and Research Institute of Texas/ ; S10 RR029119/RR/NCRR NIH HHSUnited States/ ; UTD 1907789/UT Dallas Collaborative Biomedical Research Award/ ; S10 OD018468/OD/NIH HHSUnited States/ ; P41 EB015908/EB/NIBIB NIH HHSUnited States/ ; The Texas Institute for Brain Injury and Repair/ ; R01 NS107409/NS/NINDS NIH HHSUnited States/ ; S10 OD018468/CD/ODCDC CDC HHSUnited States/ ; I-2009-20190330/The Welch Foundation/
• Volume:
  86
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:64fb0114f3e93c225d3b93023d45893376a1ef489b2c29cedaa35efb61df6bff
• Download URL:
  https://stacks.cdc.gov/view/cdc/107384/cdc_107384_DS1.pdf
• File Type:
  [PDF - 1.69 MB ]