CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Cardiac T2* Measurement of Hyperpolarized 13C Metabolites using Metabolite-Selective Multi-Echo Spiral Imaging
-
9 2021
-
-
Source: Magn Reson Med. 86(3):1494-1504
[PDF-1.69 MB]
Details:
-
Alternative Title:Magn Reson Med
-
Personal Author:
-
Description:Purpose:
Noninvasive imaging with hyperpolarized pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as T2*s of the hyperpolarized signals is critical. This study is to measure in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and the products in rodents and humans.
Methods:
A dynamic 13C multi-echo spiral imaging sequence that acquires [13C]bicarbonate, [1-13C]lactate, and [1-13C]pyruvate images in an interleaved manner was implemented for a clinical 3T system. T2* of each metabolite was calculated from the multi-echo images by fitting the signal decay of each region of interest mono-exponentially. The performance of measuring T2* using the sequence was validated using a 13C phantom, then with rodents following a bolus injection of hyperpolarized [1-13C]pyruvate. In humans, T2* of each metabolite was calculated for left ventricle (LV), right ventricle (RV) and myocardium.
Results:
Cardiac T2*s of hyperpolarized [1-13C]pyruvate, [1-13C]lactate and [13C]bicarbonate in rodents were measured as 24.9 ± 5.0, 16.4 ± 4.7, and 16.9 ± 3.4 ms, respectively. In humans, T2* of [1-13C]pyruvate was 108.7 ± 22.6 ms in LV and 129.4 ± 8.9 ms in RV. T2* of [1-13C]lactate was 40.9 ± 8.3, 44.2 ± 5.5, and 43.7 ± 9.0 ms in LV, RV and myocardium, respectively. T2* of [13C]bicarbonate in myocardium was 64.4 ± 2.5 ms. The measurements were reproducible and consistent over time after the pyruvate injection.
Conclusions:
The proposed metabolite-selective multi-echo spiral imaging sequence reliably measures in vivo cardiac T2*s of hyperpolarized [1-13C]pyruvate and products.
-
Subjects:
-
Source:
-
Pubmed ID:33821504
-
Pubmed Central ID:PMC8212421
-
Document Type:
-
Funding:
-
Volume:86
-
Issue:3
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
Supporting Files
-
gif 
jpeg 
gif 
jpeg 
gif 
jpeg 
gif 
jpeg 
xml 
pdf 
gif 
jpeg 
gif 
jpeg 
gif 
jpeg 
gif 
jpeg
