Publishing interim early or mid-season influenza vaccine effectiveness – US Flu VE Network

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Chung, Jessie R. ; Flannery, Brendan ; Kim, Sara S. ; Gaglani, Manjusha ; Raiyani, Chandni ; Belongia, Edward A. ; McLean, Huong Q. ; Nowalk, Mary Patricia ; Zimmerman, Richard K. ; Jackson, Michael L. ; Jackson, Lisa A. ; Martin, Emily T. ; Monto, Arnold S. ; Patel, Manish
• Description:
  Introduction:
  
  Mid-season influenza vaccine effectiveness (VE) estimates are a useful tool to help guide annual influenza vaccine strain selection, vaccine policy, and public health messaging. We propose using a sample size-driven approach with data-driven inputs for publication of mid-season influenza VE.
  
  Methods:
  
  We used pooled inputs for VE by (sub)type and average vaccine coverage by age groups using data from eight seasons of the US Influenza VE Network to calculate sample sizes needed to estimate mid-season VE.
  
  Results:
  
  We estimate that 135 influenza-positive cases would be needed to detect an overall VE of 40% with 55% vaccine coverage among test-negative controls. Larger sample sizes would be required to produce reliable estimates specifically against influenza A/H3N2 and for older age groups.
  
  Conclusion:
  
  Using an existing network, most of the recent influenza seasons in the US would facilitate valid mid-season VE estimates using the proposed sample sizes for broad age groupings.
  
  
• Subjects:
  Aged Article Case-Control Studies Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza Vaccines Sample Size Seasons United States Vaccination

  More +
• Source:
  Vaccine. 39(25):3324-3328
• Pubmed ID:
  33994240
• Pubmed Central ID:
  PMC8204739
• Document Type:
  Journal Article
• Funding:
  U01 IP001037/IP/NCIRD CDC HHSUnited States/ ; UL1 TR001857/TR/NCATS NIH HHSUnited States/ ; U01 IP001034/IP/NCIRD CDC HHSUnited States/ ; U01 IP000136/IP/NCIRD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 IP001039/IP/NCIRD CDC HHSUnited States/ ; U01IP001039/ACL/ACL HHSUnited States/ ; U01 IP001035/IP/NCIRD CDC HHSUnited States/ ; U01 IP001038/IP/NCIRD CDC HHSUnited States/
• Volume:
  39
• Issue:
  25
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fdc7f00b930edc943b4b0fd6df3cd3468bb6bd9e91068a1c032860c64e2c2cd1
• Download URL:
  https://stacks.cdc.gov/view/cdc/107361/cdc_107361_DS1.pdf
• File Type:
  [PDF - 357.59 KB ]