Demographic, clinical, and epidemiologic characteristics of persons under investigation for Coronavirus Disease 2019—United States, January 17–February 29, 2020

Details

• Alternative Title:
  PLoS One
• Personal Author:
  McGovern, Olivia L. ; Stenger, Mark ; Oliver, Sara E. ; Anderson, Tara C. ; Isenhour, Cheryl ; Mauldin, Matthew R. ; Williams, Nia ; Griggs, Eric ; Bogere, Tonny ; Edens, Chris ; Curns, Aaron T. ; Lively, Joana Y. ; Zhou, Yingtao ; Xu, Songli ; Diaz, Maureen H. ; Waller, Jessica L. ; Clarke, Kevin R. ; Evans, Mary E. ; Hesse, Elisabeth M. ; Morris, Sapna Bamrah ; McClung, Robert P. ; Cooley, Laura A. ; Logan, Naeemah ; Boyd, Andrew T. ; Taylor, Allan W. ; Bajema, Kristina L. ; Lindstrom, Stephen ; Elkins, Christopher A. ; Jones, Christopher ; Hall, Aron J. ; Graitcer, Samuel ; Oster, Alexandra M. ; Fry, Alicia M. ; Fischer, Marc ; Conklin, Laura ; Gokhale, Runa H.
• Description:
  Background
  
  The Coronavirus Disease 2019 (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), evolved rapidly in the United States. This report describes the demographic, clinical, and epidemiologic characteristics of 544 U.S. persons under investigation (PUI) for COVID-19 with complete SARS-CoV-2 testing in the beginning stages of the pandemic from January 17 through February 29, 2020.
  
  Methods
  
  In this surveillance cohort, the U.S. Centers for Disease Control and Prevention (CDC) provided consultation to public health and healthcare professionals to identify PUI for SARS-CoV-2 testing by quantitative real-time reverse-transcription PCR. Demographic, clinical, and epidemiologic characteristics of PUI were reported by public health and healthcare professionals during consultation with on-call CDC clinicians and subsequent submission of a CDC PUI Report Form. Characteristics of laboratory-negative and laboratory-positive persons were summarized as proportions for the period of January 17−February 29, and characteristics of all PUI were compared before and after February 12 using prevalence ratios.
  
  Results
  
  A total of 36 PUI tested positive for SARS-CoV-2 and were classified as confirmed cases. Confirmed cases and PUI testing negative for SARS-CoV-2 had similar demographic, clinical, and epidemiologic characteristics. Consistent with changes in PUI evaluation criteria, 88% (13/15) of confirmed cases detected before February 12, 2020, reported travel from China. After February 12, 57% (12/21) of confirmed cases reported no known travel- or contact-related exposures.
  
  Conclusions
  
  These findings can inform preparedness for future pandemics, including capacity for rapid expansion of novel diagnostic tests to accommodate broad surveillance strategies to assess community transmission, including potential contributions from asymptomatic and presymptomatic infections.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Cohort Studies Coronavirus Infections COVID-19 COVID-19 Nucleic Acid Testing Epidemiological Monitoring Female Humans Male Middle Aged Public Health SARS-CoV-2 Travel Travel-Related Illness Young Adult

  More +
• Source:
  PLoS One. 16(4)
• Pubmed ID:
  33857209
• Pubmed Central ID:
  PMC8049245
• Document Type:
  Journal Article
• Name as Subject:
  Centers for Disease Control and Prevention (U.S.)
• Place as Subject:
  United States
• Volume:
  16
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e7a4726c168fa32febaf72b10de737a345985004ef9831ffcefabfafcaeeeb44
• Download URL:
  https://stacks.cdc.gov/view/cdc/107350/cdc_107350_DS1.pdf
• File Type:
  [PDF - 528.87 KB ]