The Relationship between Traffic-Related Air Pollution Exposures and Allostatic Load Score among Youth with Type 1 Diabetes in the SEARCH Cohort

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Montresor-López, Jessica A. ; Reading, Stephanie R. ; Yanosky, Jeffrey D. ; Mittleman, Murray A. ; Bell, Ronny A. ; Crume, Tessa L. ; Dabelea, Dana ; Dolan, Lawrence ; D’Agostino, Ralph B. ; Marcovina, Santica M. ; Pihoke, Catherine ; Reynolds, Kristi ; Urbina, Elaine ; Liese, Angela D. ; Quirós-Alcalá, Lesliam ; Smith, J. Carson ; de Mesquita, P. Jacob Bueno ; Puett, Robin C.
• Description:
  Objective:
  
  We investigated the effects of chronic exposures to particulate and traffic-related air pollution on allostatic load (AL) score, a marker of cumulative biological risk, among youth with type 1 diabetes.
  
  Research Design and Methods:
  
  Participants were drawn from five clinical sites of the SEARCH for Diabetes in Youth (SEARCH) study (n=2,338). Baseline questionnaires, anthropometric measures, and a fasting blood test were taken at a clinic visit between 2001 and 2005. AL was operationalized using 10 biomarkers reflecting cardiovascular, metabolic, and inflammatory risk. Annual residential exposures to PM2.5 and proximity to heavily-trafficked major roadways were estimated for each participant. Poisson regression models adjusted for sociodemographic and lifestyle factors were conducted for each exposure.
  
  Results:
  
  No significant associations were observed between exposures to PM2.5 or proximity to traffic and AL score, however analyses were suggestive of effect modification by race for residential distance to heavily-trafficked major roadways (p=0.02). In stratified analyses, residing <100, 100-<200 and 200-<400 m compared to 400 m or more from heavily-trafficked major roadways was associated with 11%, 26% and 14% increases in AL score, respectively (95% CIs: −4, 29; 9, 45.0; −1, 30) for non-white participants compared to 6%, −2%, and −2% changes (95% CIs: −2, 15; −10, 7; −8, 6) for white participants.
  
  Conclusions:
  
  Among this population of youth with type 1 diabetes, we did not observe consistent relationships between chronic exposures to particulate and traffic-related air pollution and changes in AL score, however associations for traffic-related pollution exposures may differ by race/ethnicity and warrant further examination.
  
  
• Subjects:
  Adolescent Air Pollutants Air Pollution Allostasis Diabetes Mellitus, Type 1 Environmental Exposure Humans Particulate Matter Traffic-Related Pollution Vehicle Emissions
• Keywords:
  Air Pollution Allostatic Load Chronic Exposure Type 1 Diabetes
• Source:
  Environ Res. 197:111075
• Pubmed ID:
  33798519
• Pubmed Central ID:
  PMC8187288
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U18DP006139/ACL/ACL HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006138/ACL/ACL HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; UL1 TR002535/TR/NCATS NIH HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000062/TR/NCATS NIH HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; U18DP006131/ACL/ACL HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; R01 ES019168/ES/NIEHS NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  197
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4a07ba1901cbb7d8c8ff9f0174f54ff213f1f5666db203437141824bef0a1ee1
• Download URL:
  https://stacks.cdc.gov/view/cdc/107257/cdc_107257_DS1.pdf
• File Type:
  [PDF - 337.68 KB ]