Particulate Matter and Alzheimer’s Disease: An Intimate Connection

Details

• Alternative Title:
  Trends Mol Med
• Personal Author:
  O’Piela, Devin R. ; Durisek, George R. ; Escobar, Yael-Natalie H. ; Mackos, Amy R. ; Wold, Loren E.
• Description:
  The environmental role in disease progression has been appreciated for decades; however, understanding how airborne toxicant exposure can affect organs beyond the lungs is an underappreciated area of scientific inquiry. Particulate matter (PM) includes various gases, liquids, and particles in suspension and is produced by industrial activities such as fossil fuel combustion and natural events including wildfires and volcanic eruptions. Although agencies have attempted to reduce acceptable airborne particulate levels, with urbanization and population growth, these policies have been only moderately effective in mitigating disease progression. A growing area of research is focused on the role of PM exposure in the progression of Alzheimer's disease (AD). This review will summarize the knowns and unknowns of this expanding field.
• Subjects:
  Air Pollutants Air Pollution Alzheimer Disease Disease Progression Humans Particulate Matter
• Keywords:
  Air Pollution Alzheimer’s Disease Neurodegenerative Disease Particulate Matter
• Source:
  Trends Mol Med. 28(9):770-780
• Pubmed ID:
  35840480
• Pubmed Central ID:
  PMC9420776
• Document Type:
  Journal Article
• Funding:
  R01 AG057046/AG/NIA NIH HHSUnited States/ ; R01 HL139348/HL/NHLBI NIH HHSUnited States/ ; T32 HL149637/HL/NHLBI NIH HHSUnited States/ ; U01 OH012056/OH/NIOSH CDC HHSUnited States/
• Volume:
  28
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6721e1a0c53e5e58b012a68cb99b5a069283ccb9da7a6fd546d65ed76239be971f0c3fc67ad6c1cb3e768ff19386ea2d9ecf93cdadac75e1d196b6082ff37970
• Download URL:
  https://stacks.cdc.gov/view/cdc/175622/cdc_175622_DS1.pdf
• File Type:
  [PDF - 890.47 KB ]