Propranolol Kinetics in Plasma from Severely Burned Adults

Details

• Alternative Title:
  Burns
• Personal Author:
  Guillory, Ashley N. ; Herndon, David N. ; Silva, Michael B. ; Andersen, Clark R. ; Edgu-Fry, Erge ; Suman, Oscar E. ; Finnerty, Celeste C.
• Description:
  Objectives:
  
  The aim of this study was to determine the appropriate propranolol dosing strategy for reducing heart rate in severely burned adults.
  
  Methods:
  
  A total of 26 patients (≥18 years) with burns covering ≥30% of the total body surface area were included in this IRB-approved study. Plasma propranolol concentrations were determined in a placebo group (n=10) or following one of three dosing strategies: Q6 (n=4), Q8 (n=6), and Q24 (n=6). Blood was collected just before dosing and at regular intervals over two dosing periods with corresponding heart rate and blood pressure recordings. Statistical significance was determined by one-way ANOVA followed by the appropriate post-hoc test.
  
  Results:
  
  Heart rate was 86±2 bpm for Q6, 93±3 bpm for Q8, and 90±4 bpm for Q24. The Q8 group had a significantly higher heart rate than the Q6 group (p=0.0001). Plasma propranolol concentrations were significantly higher in the Q6 dosing strategy than in the Q8 dosing strategy (p=0.02).
  
  Conclusions:
  
  Heart rate can be decreased to a similar degree with Q6 and Q24 dosing strategies, with the Q8 dosing strategy being less effective. Q6 dosing is recommended to maintain reduced heart rate throughout dosing periods.
  
  Trial Registration:
  
  NCT01902810 and NCT00675714.
  
  
• Subjects:
  Adrenergic Beta-Antagonists Adult Arterial Pressure Article Blood Pressure Body Surface Area Burns Female Heart Rate Humans Male Middle Aged Propranolol Trauma Severity Indices β-adrenergic Receptor Antagonists

  More +
• Source:
  Burns. 43(6):1168-1174
• Pubmed ID:
  28645713
• Pubmed Central ID:
  PMC8173765
• Document Type:
  Journal Article
• Funding:
  R01 GM112936/GM/NIGMS NIH HHS/United States ; KL2 RR029875/RR/NCRR NIH HHS/United States ; U48 DP000043/DP/NCCDPHP CDC HHS/United States ; R01 GM056687/GM/NIGMS NIH HHS/United States ; P50 GM060338/GM/NIGMS NIH HHS/United States ; T32 GM008256/GM/NIGMS NIH HHS/United States ; UL1 TR001439/TR/NCATS NIH HHS/United States ; UL1 RR029876/RR/NCRR NIH HHS/United States
• Volume:
  43
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:761d48498af13ded87fe593384433073e979225c3b9cfa9559ebdbc9b5511c30
• Download URL:
  https://stacks.cdc.gov/view/cdc/106848/cdc_106848_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]