Identification of porcine rotavirus-like genotype P[6] strains in Taiwanese children

Hwang, Kao-Pin; Wu, Fang-Tzy; Bányai, Krisztián; Wu, Ho-Sheng; Yang, Dustin Chen-Fu; Huang, Yhu-Chering; Lin, Jen-Shiou; Hsiung, Chao Agnes; Huang, Jason C.; Jiang, Baoming; Gentsch, Jon R.

doi:10.1099/jmm.0.042499-0

i

Identification of porcine rotavirus-like genotype P[6] strains in Taiwanese children

Supporting Files

7 2012
By Hwang, Kao-Pin ; Wu, Fang-Tzy ; Bányai, Krisztián ; ...

File Language:

English

Details

Alternative Title:

J Med Microbiol
Personal Author:

Hwang, Kao-Pin ; Wu, Fang-Tzy ; Bányai, Krisztián ; Wu, Ho-Sheng ; Yang, Dustin Chen-Fu ; Huang, Yhu-Chering ; Lin, Jen-Shiou ; Hsiung, Chao Agnes ; Huang, Jason C. ; Jiang, Baoming ; Gentsch, Jon R.
Description:

The molecular characterization of genotype P[6] rotavirus strains collected from children admitted to hospital with acute dehydrating diarrhoea during a 6-year surveillance period in Taiwan is described in this study. In total, three G4P[6] strains, one G5P[6] and one G12P[6] were characterized by sequencing and phylogenetic analysis of the VP4, VP7, VP6 and NSP4 genes. Whilst all four genes of the single Taiwanese G12P[6] strain clustered with the respective genes of globally common human rotavirus strains, the G4 and G5 strains showed remarkable similarities to porcine rotavirus strains and putative porcine-origin human P[19] strains reported previously from Taiwan. The overall proportion of porcine rotavirus-like strains in Taiwan remains around 1 % among hospitalized children; however, the circulation and sporadic transmission of these heterotypic strains from pigs to humans could pose a public-health concern. Therefore, continuation of strain monitoring is needed in the vaccine era to detect any possible vaccine breakthrough events associated with the introduction of such heterologous rotavirus strains.
Subjects:

Animals Child, Preschool Cluster Analysis Diarrhea Gastroenteritis Genotype Hospitals Humans RNA, Viral Rotavirus Rotavirus Infections Sequence Analysis, DNA Sequence Homology Swine Swine Diseases Viral Proteins Zoonoses
Source:

J Med Microbiol. 61(Pt 7):990-997
Pubmed ID:

22466032
Pubmed Central ID:

PMC8167839
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Place as Subject:

Taiwan
Volume:

61
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:b443147e61bc28c4f880c0dfc4254625a9a8df1bbe93fd9a0f6b5df67df0c124
Download URL:

https://stacks.cdc.gov/view/cdc/106785/cdc_106785_DS1.pdf
File Type:

[PDF - 725.81 KB ]

File Language:

English

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