Blood lead level association with lower body weight in NHANES 1999–2006

Details

• Alternative Title:
  Toxicol Appl Pharmacol
• Personal Author:
  Scinicariello, Franco ; Buser, Melanie C. ; Mevissen, Meike ; Portier, Christopher J.
• Description:
  Background:
  
  Lead exposure is associated with low birth-weight. The objective of this study is to determine whether lead exposure is associated with lower body weight in children, adolescents and adults.
  
  Methods:
  
  We analyzed data from NHANES 1999–2006 for participants aged ≥3 using multiple logistic and multivariate linear regression. Using age- and sex-standardized BMI Z-scores, overweight and obese children (ages 3–19) were classified by BMI ≥85th and ≥95th percentiles, respectively. The adult population (age ≥20) was classified as overweight and obese with BMI measures of 25–29.9 and ≥30, respectively. Blood lead level (BLL) was categorized by weighted quartiles.
  
  Results:
  
  Multivariate linear regressions revealed a lower BMI Z-score in children and adolescents when the highest lead quartile was compared to the lowest lead quartile (β (SE) = −0.33 (0.07), p < 0.001), and a decreased BMI in adults (β (SE) = −2.58 (0.25), p < 0.001). Multiple logistic analyses in children and adolescents found a negative association between BLL and the percentage of obese and overweight with BLL in the highest quartile compared to the lowest quartile (OR = 0.42, 95% CI: 0.30–0.59; and OR = 0.67, 95% CI: 0.52–0.88, respectively). Adults in the highest lead quartile were less likely to be obese (OR = 0.42, 95% CI: 0.35–0.50) compared to those in the lowest lead quartile. Further analyses with blood lead as restricted cubic splines, confirmed the dose-relationship between blood lead and body weight outcomes.
  
  Conclusions:
  
  BLLs are associated with lower body mass index and obesity in children, adolescents and adults.
  
  
• Subjects:
  Adolescent Adult Adults Article Body Mass Index Body Weight Child Child, Preschool Children Cross-Sectional Studies Environmental Monitoring Female Humans Lead Linear Models Logistic Models Male Multivariate Analysis NHANES Nutrition Surveys Obesity Overweight Young Adult

  More +
• Source:
  Toxicol Appl Pharmacol. 273(3):516-523
• Pubmed ID:
  24099784
• Pubmed Central ID:
  PMC8158151
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  273
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cc1eaf37e6d8f4674806e0ae3f67799c5af8c298d2ea4698e66b3eed47f48f0d
• Download URL:
  https://stacks.cdc.gov/view/cdc/106689/cdc_106689_DS1.pdf
• File Type:
  [PDF - 865.44 KB ]