Perfluoroalkyl substances and food allergies in adolescents

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Buser, Melanie C. ; Scinicariello, Franco
• Description:
  Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a class of organic compounds that are persistent in the environment due to their stable carbon-fluorine backbone, which is not susceptible to degradation. Research suggests these chemicals may exert an immunotoxic effect. The aim of this study is to investigate the associations between four PFASs - perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) - with food sensitization and food allergies in adolescent participants (ages 12-19years) in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2007-2010, respectively. We performed multivariate logistic regression to analyze the association between individual PFASs with food sensitization (defined as having at least 1 food-specific IgE level≥0.35kU/L) in NHANES 2005-2006 and food allergies (self-reported) in NHANES 2007-2010. Serum PFOA, PFOS, and PFHxS were statistically significantly associated with higher odds to have self-reported food allergies in NHANES 2007-2010. When using IgE levels as a marker of food sensitization, we found that serum PFNA was inversely associated with food sensitization (NHANES 2005-2006). In conclusion, we found that serum levels of PFASs were associated with higher odds to have self-reported food allergies. Conversely, adolescents with higher serum PFNA were less likely to be sensitized to food allergens. These results, along with previous studies, warrant further investigation, such as well-designed longitudinal studies.
• Subjects:
  Adolescent Biomarkers Cross-Sectional Studies Female Fluorocarbons Food Hypersensitivity Humans Logistic Models Male Nutrition Surveys Prevalence Regression Analysis Young Adult

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• Source:
  Environ Int. 88:74-79
• Pubmed ID:
  26722671
• Pubmed Central ID:
  PMC8132312
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Name as Subject:
  National Health and Nutrition Examination Survey (U.S.)
• Place as Subject:
  United States
• Volume:
  88
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:990aca9b0b6e30e5da577bba72d1144e3f2070ad7feb5685b7f778865d723b76
• Download URL:
  https://stacks.cdc.gov/view/cdc/106473/cdc_106473_DS1.pdf
• File Type:
  [PDF - 85.54 KB ]