Details:

Alternative Title:
Ann Epidemiol
Publisher's site:
http://dx.doi.org/10.1016/j.annepidem.2021.01.004
Personal Author:
Shariff-Marco, Salma ; DeRouen, Mindy C. ; Yang, Juan ; Jain, Jennifer ; Nelson, David O. ; ... More +
Shariff-Marco, Salma ; DeRouen, Mindy C. ; Yang, Juan ; Jain, Jennifer ; Nelson, David O. ; Weden, Margaret M. ; Gomez, Scarlett L. Less -
Description:
Purpose:

Previous studies on neighborhoods and breast cancer survival examined neighborhood variables as unidimensional measures (e.g. walkability or deprivation) individually and thus cannot inform how the multitude of highly correlated neighborhood domains interact to impact breast cancer survival. Neighborhood archetypes were developed that consider interactions among a broad range of neighborhood social and built environment attributes and examine their associations with breast cancer survival.

Methods:

Archetypes were measured using latent class analysis (LCA) fit to California census tract-level data. Thirty-nine social and built environment attributes relevant to eight neighborhood domains (socioeconomic status, urbanicity, demographics, housing, land use, commuting and traffic, residential mobility, and food environment) were included. The archetypes were linked to cancer registry data on breast cancer cases (diagnosed 1996–2005 with follow-up through Dec 31, 2017) to evaluate their associations with overall and breast cancer-specific survival using Cox proportional hazard models. Analyses were stratified by race/ethnicity.

Results:

California neighborhoods were best described by nine archetypal patterns that were differentially associated with overall and breast cancer-specific survival. The lowest risk of overall death was observed in the upper middle class suburb (reference) and high status neighborhoods, while the highest was observed among inner city residents with a 39% greater risk of death (95% CI = 1.35 to 1.44). Results were similar for breast cancer-specific survival. Stratified analyses indicated that differences in survival by neighborhood archetype varied according to individuals’ race/ethnicity.

Conclusions:

By describing neighborhood archetypes that differentiate survival following breast cancer diagnosis, the study provides direction for policy and clinical practice addressing contextually-rooted social determinants of health including SES, unhealthy food environments, and greenspace.


Subject:
[+]
Article
Breast Cancer
Breast Neoplasms
California
Cancer Survival
Ethnicity
Geographic Disparities
Humans
Latent Class Analysis
Neighborhood Archetypes
Neighborhood Socioeconomic Status
Racial/ethnic Disparities
Residence Characteristics
Social Class
Socioeconomic Factors

Source:
Ann Epidemiol. 57:22-29
Pubmed ID:
33577928
Pubmed Central ID:
PMC8133764
Document Type:
Journal Article
Funding:
HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; ... More +
HHSN261201800032C/CA/NCI NIH HHSUnited States/ ; HHSN261201800009C/CA/NCI NIH HHSUnited States/ ; NU58DP006344/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201800015I/CA/NCI NIH HHSUnited States/ ; HHSN261201800032I/CA/NCI NIH HHSUnited States/ ; HHSN261201800015C/CA/NCI NIH HHSUnited States/ ; R21 CA174469/CA/NCI NIH HHSUnited States/ ; HHSN261201800009I/CA/NCI NIH HHSUnited States/ Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e4467e8dc9bc8e880bf2043c4a18029f5e807caba3d050fc49ccfb855177fd11
File Type:

Supporting Files

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  	NIHMS1672357-supplement-Supp_Tables.docx	docx

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