Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chu, Daniel K.W. ; Hui, Kenrie P.Y. ; Gu, Haogao ; Ko, Ronald L.W. ; Krishnan, Pavithra ; Ng, Daisy Y.M. ; Liu, Gigi Y.Z. ; Wan, Carrie K.C. ; Cheung, Man-Chun ; Ng, Ka-Chun ; Nicholls, John M. ; Tsang, Dominic N.C. ; Peiris, Malik ; Chan, Michael C.W. ; Poon, Leo L.M.
• Description:
  We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
• Subjects:
  Coronavirus Infections Covid-19/Genetics Sars-Cov-2 Genetics
• Source:
  Emerg Infect Dis. 27(5):1492-1495
• Pubmed ID:
  33900193
• Pubmed Central ID:
  PMC8084491
• Document Type:
  Journal Article
• Place as Subject:
  Hong Kong
• Volume:
  27
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cb98dba30ba81a16d951128c512b17edde6e097838469a04e05463426183b407
• Download URL:
  https://stacks.cdc.gov/view/cdc/106039/cdc_106039_DS1.pdf
• File Type:
  [PDF - 1.40 MB ]