Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China

Chu, Daniel K.W.; Hui, Kenrie P.Y.; Gu, Haogao; Ko, Ronald L.W.; Krishnan, Pavithra; Ng, Daisy Y.M.; Liu, Gigi Y.Z.; Wan, Carrie K.C.; Cheung, Man-Chun; Ng, Ka-Chun; Nicholls, John M.; Tsang, Dominic N.C.; Peiris, Malik; Chan, Michael C.W.; Poon, Leo L.M.

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China

May 2021
By Chu, Daniel K.W. ; Hui, Kenrie P.Y. ; Gu, Haogao ; ...
Source: Emerg Infect Dis. 27(5):1492-1495

[PDF-1.40 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Chu, Daniel K.W. ; Hui, Kenrie P.Y. ; Gu, Haogao ; Ko, Ronald L.W. ; Krishnan, Pavithra ; ... More +

Chu, Daniel K.W. ; Hui, Kenrie P.Y. ; Gu, Haogao ; Ko, Ronald L.W. ; Krishnan, Pavithra ; Ng, Daisy Y.M. ; Liu, Gigi Y.Z. ; Wan, Carrie K.C. ; Cheung, Man-Chun ; Ng, Ka-Chun ; Nicholls, John M. ; Tsang, Dominic N.C. ; Peiris, Malik ; Chan, Michael C.W. ; Poon, Leo L.M. Less -
Description:

We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.
Subjects:

[+]

Coronavirus Infections Covid-19/Genetics Sars-Cov-2 Genetics
Source:

Emerg Infect Dis. 27(5):1492-1495
Pubmed ID:

33900193
Pubmed Central ID:

PMC8084491
Document Type:

Journal Article
Place as Subject:

Hong Kong
Volume:

27
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:cb98dba30ba81a16d951128c512b17edde6e097838469a04e05463426183b407
Download URL:

https://stacks.cdc.gov/view/cdc/106039/cdc_106039_DS1.pdf
File Type:

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	21-0015-F2.jpg	jpeg
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