Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Fintelman-Rodrigues, Natalia ; da Silva, Aline P.D. ; dos Santos, Monique Cristina ; Saraiva, Felipe B. ; Ferreira, Marcelo A. ; Gesto, João ; Rodrigues, Danielle A.S. ; Vale, André M. ; de Azevedo, Isaclaudia G. ; Soares, Vinícius C. ; Jiang, Hui ; Tan, Hongdong ; Tschoeke, Diogo A. ; Sacramento, Carolina Q. ; Bozza, Fernando A. ; Morel, Carlos M. ; Bozza, Patrícia T. ; Souza, Thiago Moreno L. ; Fintelman-Rodrigues, Natalia ; da Silva, Aline P.D. ; dos Santos, Monique Cristina ; Saraiva, Felipe B. ; Ferreira, Marcelo A. ; Gesto, João ; Rodrigues, Danielle A.S. ; Vale, André M. ; de Azevedo, Isaclaudia G. ; Soares, Vinícius C. ; Jiang, Hui ; Tan, Hongdong ; Tschoeke, Diogo A. ; Sacramento, Carolina Q. ; Bozza, Fernando A. ; Morel, Carlos M. ; Bozza, Patrícia T. ; Souza, Thiago Moreno L.
• Description:
  The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
• Subjects:
  Coronavirus Infections Covid-19 Sars-Cov-2
• Source:
  Emerg Infect Dis. 27(5):1446-1453 ; Emerg Infect Dis. 27(5):1446-1453
• Pubmed ID:
  33797393
• Pubmed Central ID:
  PMC8084520
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  27
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c8b73bd02811963b35aee1428a875da8df7ce0b38a73f50ac0fcb3e76f912281
• Download URL:
  https://stacks.cdc.gov/view/cdc/106034/cdc_106034_DS1.pdf
• File Type:
  [PDF - 1.75 MB ]