Genomic Surveillance of a Globally Circulating Distinct Group W Clonal Complex 11 Meningococcal Variant, New Zealand, 2013–2018

Yang, Zuyu; Ren, Xiaoyun; Davies, Heather; Wood, Timothy; Lopez, Liza; Sherwood, Jill; Tiong, Audrey; Carter, Philip E.

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Genomic Surveillance of a Globally Circulating Distinct Group W Clonal Complex 11 Meningococcal Variant, New Zealand, 2013–2018

Supporting Files Public Domain

Apr 2021
By Yang, Zuyu ; Ren, Xiaoyun ; Davies, Heather ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Yang, Zuyu ; Ren, Xiaoyun ; Davies, Heather ; Wood, Timothy ; Lopez, Liza ; Sherwood, Jill ; Tiong, Audrey ; Carter, Philip E.
Description:

Genomic surveillance is an essential part of effective disease control, enabling identification of emerging and expanding strains and monitoring of subsequent interventions. Whole-genome sequencing was used to analyze the genomic diversity of all Neisseria meningitidis isolates submitted to the New Zealand Meningococcal Reference Laboratory during 2013-2018. Of the 347 isolates submitted for whole-genome sequencing, we identified 68 sequence types belonging to 18 clonal complexes (CC). The predominant CC was CC41/44; next in predominance was CC11. Comparison of the 45 New Zealand group W CC11 isolates with worldwide representatives of group W CC11 isolates revealed that the original UK strain, the 2013 UK strain, and a distinctive variant (the 2015 strain) were causing invasive group W meningococcal disease in New Zealand. The 2015 strain also demonstrated increased resistance to penicillin and has been circulating in Canada and several countries in Europe, highlighting that close monitoring is needed to prevent future outbreaks around the world.
Subjects:

Bacteria Evolution Genomic Surveillance Of A Globally Circulating Distinct Group W Clonal Complex 11 Meningococcal Variant, New Zealand, 2013–2018 Group W Invasive Meningococcal Disease Meningitis/Encephalitis Meningococcal Disease Neisseria Meningitidis Public Health Surveillance Research Whole-Genome Sequencing
Source:

Emerg Infect Dis. 27(4):1087-1097
Pubmed ID:

33754994
Pubmed Central ID:

PMC8007299
Document Type:

Journal Article
Place as Subject:

New Zealand
Volume:

27
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:fc25441f81a5faa3aaa1b16c5f806b3dde74664688d9f94ddebf868594d71973
Download URL:

https://stacks.cdc.gov/view/cdc/104853/cdc_104853_DS1.pdf
File Type:

[PDF - 6.85 MB ]

File Language:

English

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