i
NIOSH skin notation (SK) profile : cyclonite
-
October 2020
Details:
-
Personal Author:
-
Corporate Authors:
-
Description:"No in vivo toxicokinetic data were identified that estimated the degree of absorption of cyclonite through human or animal skin following dermal exposure. In vitro toxicokinetic data identified from animals [Reifenrath et al. 2002; Reddy et al. 2008], with support from a model prediction, indicate that cyclonite has a limited potential for skin absorption (absorption of less than 10% of the applied dose) whether applied in acetone or in soil. Five case reports identified CNS effects in workers exposed to powdered cyclonite [Kaplan et al. 1965]; however, the route of exposure is unknown and could have occurred via inhalation and ingestion in addition to the dermal route of exposure. Acute toxicity studies indicated that the LD50 for cyclonite was greater than 2000 mg/kg for guinea pigs [McNamara et al. 1974], and single and repeat-dose toxicity studies in rabbits and dogs found no gross or microscopic abnormalities [McNamara et al. 1974]. One study involving humans indicated that dry cyclonite was not a skin irritant [von Oettingen et al. 1949]. However, in animals, evidence from single and repeat-dose studies using different solvents indicate that cyclonite is irritating to the skin following repeated exposures in rabbits and at doses of 1000 mg/kg or greater in guinea pigs [McNamara et al. 1974]. No diagnostic (human patch) tests were identified that evaluated the potential of cyclonite to cause skin sensitization. A skin sensitization study in guinea pigs [McNamara et al. 1974] found no evidence of the potential of cyclonite to cause skin sensitization. Based on the available data, this assessment assigns a composite skin notation of SK: DIR(IRR) for cyclonite. Table 3 summarizes the skin hazard designations for cyclonite previously issued by NIOSH and other organizations. There were no equivalent dermal designations for cyclonite, according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals [European Parliament 2008]." - NIOSHTIC-2
NIOSHTIC no. 20061331
Suggested citation: NIOSH [2020]. NIOSH skin notation profile: cyclonite. By Hudson NL. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2021-104. DOI:https://doi.org/10.26616/NIOSHPUB2021104
2021-104.pdf?id=10.26616/NIOSHPUB2021104
-
Subjects:
-
Series:
-
Document Type:
-
NIOSHTIC Number:20061331
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type: