NIOSH Skin Notation (SK) Profile: Diethylenetriamine (DETA)

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L.
• Description:
  Although there were no toxicokinetic studies that estimated the extent of dermal absorption of DETA identified in humans or animals, acute dermal toxicity studies [Smyth and Carpenter 1944; Smyth et al. 1949; Union Carbide Corporation 1977] sufficiently demonstrate that DETA is absorbed through the skin and is acutely toxic. A limited number of human studies were identified that evaluated the potential of DETA to cause direct skin effects. However, sufficient evidence is provided by animal data [Smyth et al. 1949; Dow Chemical Company 1951; Hine et al. 1958; American Cyanamid Company 1969; Union Carbide Corporation 1977] to demonstrate that DETA is corrosive to the skin at high concentrations, whereas more-dilute solutions are likely to cause skin irritation. Information from diagnostic patch tests in humans [Booth et al. 1962; Kligman 1966; Ormerod 1989] and from predictive tests in animals (GPMTs and murine LLNAs) [Thorgeirssen 1978; Union Carbide Chemicals 1990; Basketter et al. 1994; Leung and Aulette 1997] is sufficient to show that exposure to DETA causes skin sensitization and can induce cross-sensitization with structurally similar amines. On the basis of the available data, a composite skin notation of SK-SYS-DIR(COR)-SEN is assigned to DETA. Table 3 summarizes the skin hazard designations for DETA previously issued by NIOSH and other organizations. The equivalent dermal designations for DETA, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, are Acute Toxicity Category 4 (Hazard statement: Harmful in contact with the skin), Skin Corrosion Category 1B (Hazard statement: Causes severe skin burns and eye damage), and Skin Sensitization Category 1 (May cause an allergic skin reaction) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Carcinogens Environmental Exposure Epidemiology Hazardous Substances Hypersensitivity Irritants Occupational Health Risk Assessment Risk Factors Safety Skin Toxicology Urogenital System

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• Keywords:
  Skin notations; Diethylenetriamine; Epidemiology; Toxicology; Exposure levels; Risk factors; Hazards; Health effects; Dermal exposures; Skin exposure; Toxins; Carcinogenicity; Chemicals; Chemical hazards; Reproductive effects; Developmental disorders; Irritants; Sensitization
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2021-102, 2020 Oct; :1-9
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2021102
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  24 pdf pages
• NIOSHTIC Number:
  nn:20061329
• NTIS Accession Number:
  PB2022-100333
• CAS Registry Number:
  Diethylenetriamine (CAS RN 111-40-0)
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5420fe63f931e065407f9b54b5b054fbc757a19078456bcaaeb09d9e8a9b03042e4e7bca1bcd79537d2570f757e70d42b23dfb34a465ce43d31821ba01774f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/104548/cdc_104548_DS1.pdf
• File Type:
  [PDF - 394.59 KB ]