NIOSH Skin Notation (SK) Profile: Diethylenetriamine (DETA)

Details

• Personal Author:
  Hudson, Naomi L.
• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  "Although there were no toxicokinetic studies that estimated the extent of dermal absorption of DETA identified in humans or animals, acute dermal toxicity studies [Smyth and Carpenter 1944
  
  Smyth et al. 1949
  
  Union Carbide Corporation 1977] sufficiently demonstrate that DETA is absorbed through the skin and is acutely toxic. A limited number of human studies were identified that evaluated the potential of DETA to cause direct skin effects. However, sufficient evidence is provided by animal data [Smyth et al. 1949
  
  Dow Chemical Company 1951
  
  Hine et al. 1958
  
  American Cyanamid Company 1969
  
  Union Carbide Corporation 1977] to demonstrate that DETA is corrosive to the skin at high concentrations, whereas more-dilute solutions are likely to cause skin irritation. Information from diagnostic patch tests in humans [Booth et al. 1962
  
  Kligman 1966
  
  Ormerod 1989] and from predictive tests in animals (GPMTs and murine LLNAs) [Thorgeirssen 1978
  
  Union Carbide Chemicals 1990
  
  Basketter et al. 1994
  
  Leung and Aulette 1997] is sufficient to show that exposure to DETA causes skin sensitization and can induce cross-sensitization with structurally similar amines. On the basis of the available data, a composite skin notation of SK-SYS-DIR(COR)-SEN is assigned to DETA. Table 3 summarizes the skin hazard designations for DETA previously issued by NIOSH and other organizations. The equivalent dermal designations for DETA, according to the Globally Harmonized System (GHS) for Classification and Labelling of Chemicals, are Acute Toxicity Category 4 (Hazard statement: Harmful in contact with the skin), Skin Corrosion Category 1B (Hazard statement: Causes severe skin burns and eye damage), and Skin Sensitization Category 1 (May cause an allergic skin reaction) [European Parliament 2008]." - NIOSHTIC-2
  
  NIOSHTIC no. 20061329
  
  Suggested citation: NIOSH [2020]. NIOSH skin notation profile: diethylenetriamine (DETA). By Hudson NL. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2021-102. DOI: https://doi.org/10.26616/NIOSHPUB2021102
  
  2021-102.pdf?id=10.26616/NIOSHPUB2021102
  
  
• Subjects:
  Occupational Health Safety
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2021102
• Document Type:
  Text
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  ix, 9 numbered pages
• NIOSHTIC Number:
  nn:20061329
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5420fe63f931e065407f9b54b5b054fbc757a19078456bcaaeb09d9e8a9b03042e4e7bca1bcd79537d2570f757e70d42b23dfb34a465ce43d31821ba01774f8
• Download URL:
  https://stacks.cdc.gov/view/cdc/104548/cdc_104548_DS1.pdf
• File Type:
  [PDF - 394.59 KB ]