NIOSH Skin Notation (SK) Profile: Cyclohexanol

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Hudson, Naomi L.
• Description:
  Although no toxicokinetic data were identified that estimated the percent dermal absorption of cyclohexanol in humans or animals, the mathematical model predicts that cyclohexanol may be absorbed through the skin following dermal exposure. Acute and repeat-dose [Monsanto 1978; Treon et al. 1943] toxicity studies with rabbits provide limited data indicating that cyclohexanol can be absorbed through the skin and may be acutely toxic and produce central nervous and/or peripheral nervous systems effects (tremors, narcosis, hypothermia), including death at high doses. Results from a skin irritation test in rabbits [Smyth et al. 1962; Monsanto 1978] and in vitro data using human keratinocytes [Muller-Decker et al. 1994] provide evidence that cyclohexanol has the potential to cause skin irritation, including the potential to cause localized ulcers and thickening of the skin at high doses. No case reports or diagnostic patch tests in humans or predictive tests in animals were identified upon which the skin sensitization potential of cyclohexanol can be evaluated. Therefore, this assessment assigns a composite skin notation of SK: SYS-DIR (IRR) for cyclohexanol. Table 3 summarizes the skin hazard designations for cyclohexanol issued by NIOSH and other organizations. The equivalent dermal designation for cyclohexanol according to the Globally Harmonized System (GHS) of classification and labeling of chemicals is Skin Irritation Category 2 (Causes skin irritation) [European Parliament 2008]. [Description provided by NIOSH]
• Subjects:
  Carcinogens Environmental Exposure Epidemiology Hazardous Substances Hypersensitivity Irritants Occupational Health Risk Assessment Risk Factors Safety Skin Toxicology Urogenital System

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• Keywords:
  Skin notations; Cyclohexanol; Epidemiology; Toxicology; Exposure levels; Risk factors; Hazards; Health effects; Dermal exposures; Skin exposure; Toxins; Carcinogenicity; Chemicals; Chemical hazards; Reproductive effects; Developmental disorders; Irritants; Sensitization
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2021-101, 2020 Oct; :1-8
• Series:
  NIOSH Numbered Publications
• DOI:
  https://doi.org/10.26616/NIOSHPUB2021101
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  22 pdf pages
• NIOSHTIC Number:
  nn:20061328
• NTIS Accession Number:
  PB2022-100332
• CAS Registry Number:
  Cyclohexanol (CAS RN 108-93-0)
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:022a990d3224ec90206f1566ace2c97522cb711d48c1079ae3c6b3e4547404c75081e424ffb7ea1b6f39cff54cbec667a4578d9f848f5ef8d433e24a8b9e18c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/104547/cdc_104547_DS1.pdf
• File Type:
  [PDF - 403.32 KB ]