Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society

Details

• Alternative Title:
  Lancet Respir Med
• Personal Author:
  Hatabu, Hiroto ; Hunninghake, Gary M ; Richeldi, Luca ; Brown, Kevin K ; Wells, Athol U ; Remy-Jardin, Martine ; Verschakelen, Johny ; Nicholson, Andrew G ; Beasley, Mary B ; Christiani, David C ; Estépar, Raúl San José ; Seo, Joon Beom ; Johkoh, Takeshi ; Sverzellati, Nicola ; Ryerson, Christopher J ; Barr, R Graham ; Goo, Jin Mo ; Austin, John H M ; Powell, Charles A ; Lee, Kyung Soo ; Inoue, Yoshikazu ; Lynch, David A
• Description:
  The term interstitial lung abnormalities refers to specific CT findings that are potentially compatible with interstitial lung disease in patients without clinical suspicion of the disease. Interstitial lung abnormalities are increasingly recognised as a common feature on CT of the lung in older individuals, occurring in 4-9% of smokers and 2-7% of non-smokers. Identification of interstitial lung abnormalities will increase with implementation of lung cancer screening, along with increased use of CT for other diagnostic purposes. These abnormalities are associated with radiological progression, increased mortality, and the risk of complications from medical interventions, such as chemotherapy and surgery. Management requires distinguishing interstitial lung abnormalities that represent clinically significant interstitial lung disease from those that are subclinical. In particular, it is important to identify the subpleural fibrotic subtype, which is more likely to progress and to be associated with mortality. This multidisciplinary Position Paper by the Fleischner Society addresses important issues regarding interstitial lung abnormalities, including standardisation of the definition and terminology; predisposing risk factors; clinical outcomes; options for initial evaluation, monitoring, and management; the role of quantitative evaluation; and future research needs.
• Subjects:
  Article Early Detection Of Cancer Humans Incidental Findings Lung Diseases, Interstitial Lung Neoplasms Tomography, X-Ray Computed
• Source:
  Lancet Respir Med. 8(7):726-737
• Pubmed ID:
  32649920
• Pubmed Central ID:
  PMC7970441
• Document Type:
  Journal Article
• Funding:
  R01 CA092824/CA/NCI NIH HHSUnited States/ ; R01 HL130974/HL/NHLBI NIH HHSUnited States/ ; R01 CA074386/CA/NCI NIH HHSUnited States/ ; R01 HL111024/HL/NHLBI NIH HHSUnited States/ ; R01 HL135142/HL/NHLBI NIH HHSUnited States/ ; R21 CA116271/CA/NCI NIH HHSUnited States/ ; R01 ES009860/ES/NIEHS NIH HHSUnited States/ ; R01 OH002421/OH/NIOSH CDC HHSUnited States/ ; R01 CA203636/CA/NCI NIH HHSUnited States/ ; U01 CA209414/CA/NCI NIH HHSUnited States/
• Volume:
  8
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:94353a06d4c20a862ac1ff966224d058e7105ca6de938f78f46715b351df20e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/104325/cdc_104325_DS1.pdf
• File Type:
  [PDF - 939.37 KB ]