Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA

Lewis, Nathaniel M.; Duca, Lindsey M.; Marcenac, Perrine; Dietrich, Elizabeth A.; Gregory, Christopher J.; Fields, Victoria L.; Banks, Michelle M.; Rispens, Jared R.; Hall, Aron; Harcourt, Jennifer L.; Tamin, Azaibi; Willardson, Sarah; Kiphibane, Tair; Christensen, Kimberly; Dunn, Angela C.; Tate, Jacqueline E.; Nabity, Scott; Matanock, Almea M.; Kirking, Hannah L.

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Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA

Supporting Files Public Domain

December 04 2020
By Lewis, Nathaniel M. ; Duca, Lindsey M. ; Marcenac, Perrine ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lewis, Nathaniel M. ; Duca, Lindsey M. ; Marcenac, Perrine ; Dietrich, Elizabeth A. ; Gregory, Christopher J. ; Fields, Victoria L. ; Banks, Michelle M. ; Rispens, Jared R. ; Hall, Aron ; Harcourt, Jennifer L. ; Tamin, Azaibi ; Willardson, Sarah ; Kiphibane, Tair ; Christensen, Kimberly ; Dunn, Angela C. ; Tate, Jacqueline E. ; Nabity, Scott ; Matanock, Almea M. ; Kirking, Hannah L.
Description:

Virus shedding in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur before onset of symptoms; less is known about symptom progression or infectiousness associated with initiation of viral shedding. We investigated household transmission in 5 households with daily specimen collection for 5 consecutive days starting a median of 4 days after symptom onset in index patients. Seven contacts across 2 households implementing no precautionary measures were infected. Of these 7, 2 tested positive for SARS-CoV-2 by reverse transcription PCR on day 3 of 5. Both had mild, nonspecific symptoms for 1-3 days preceding the first positive test. SARS-CoV-2 was cultured from the fourth-day specimen in 1 patient and from the fourth- and fifth-day specimens in the other. We also describe infection control measures taken in the households that had no transmission. Persons exposed to SARS-CoV-2 should self-isolate, including from household contacts, wear a mask, practice hand hygiene, and seek testing promptly.
Subjects:

Adolescent Adult Child Disease Transmission, Infectious Environmental Exposure Family Characteristics Female Humans Infection Control Male Middle Aged Specimen Handling Time Factors Virus Shedding
Source:

Emerg Infect Dis. 27(2):352-359
Pubmed ID:

33275874
Pubmed Central ID:

PMC7853554
Document Type:

Journal Article
Place as Subject:

Utah
Location:

North America
Volume:

27
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:eb2098236d859737932b3a8244ceb64d81105a59837cf47a48827e33ce957ef7
Download URL:

https://stacks.cdc.gov/view/cdc/102468/cdc_102468_DS1.pdf
File Type:

[PDF - 1.89 MB ]

File Language:

English

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