Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures

Details

• Alternative Title:
  ChemMedChem
• Personal Author:
  Sommers, Kyle J. ; Bentley, Brian S. ; Carden, Robert G. ; Post, Savannah J. ; Allen, Ryan A. ; Kontos, Renee C. ; Black, Jacob W. ; Wuest, William M. ; Minbiole, Kevin P. C.
• Description:
  Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
• Subjects:
  Anti-Bacterial Agents Antiseptics Article Benzalkonium Chloride BisQAC Dose-Response Relationship, Drug Ferrocene Ferrous Compounds Metallocenes Methicillin-Resistant Staphylococcus Aureus Methicillin-resistant Staphylococcus Aureus (MRSA) Microbial Sensitivity Tests Molecular Structure Quaternary Ammonium Compounds Structure-Activity Relationship

  More +
• Source:
  ChemMedChem. 16(3):467-471
• Pubmed ID:
  33197298
• Pubmed Central ID:
  PMC7864880
• Document Type:
  Journal Article
• Funding:
  Georgia Emerging Infections Program/ ; CHE-1827930/National Science Foundation/ ; R35 GM119426/GM/NIGMS NIH HHSUnited States/ ; DGE1937971/National Science Foundation/ ; CC/CDC HHSUnited States/
• Volume:
  16
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:da84f235788b4d67d19c0b52643964659c188491f7100eec26ca9a0e57e92f2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/102190/cdc_102190_DS1.pdf
• File Type:
  [PDF - 393.47 KB ]