Details:

Alternative Title:
ChemMedChem
Publisher's site:
http://dx.doi.org/10.1002/cmdc.202000605
Personal Author:
Sommers, Kyle J. ; Bentley, Brian S. ; Carden, Robert G. ; Post, Savannah J. ; Allen, Ryan A. ; ... More +
Sommers, Kyle J. ; Bentley, Brian S. ; Carden, Robert G. ; Post, Savannah J. ; Allen, Ryan A. ; Kontos, Renee C. ; Black, Jacob W. ; Wuest, William M. ; Minbiole, Kevin P. C. Less -
Description:
Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
Subject:
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Anti-Bacterial Agents
Antiseptics
Article
Benzalkonium Chloride
BisQAC
Dose-Response Relationship, Drug
Ferrocene
Ferrous Compounds
Metallocenes
Methicillin-Resistant Staphylococcus Aureus
Methicillin-resistant Staphylococcus Aureus (MRSA)
Microbial Sensitivity Tests
Molecular Structure
Quaternary Ammonium Compounds
Structure-Activity Relationship
Quaternary Ammonium Compounds

Source:
ChemMedChem. 16(3):467-471
Pubmed ID:
33197298
Pubmed Central ID:
PMC7864880
Document Type:
Journal Article
Funding:
Georgia Emerging Infections Program/ ; CHE-1827930/National Science Foundation/ ; R35 GM119426/GM/NIGMS NIH HHSUnited States/ ; DGE1937971/National Science Foundation/ ; CC/CDC HHSUnited States/
Georgia Emerging Infections Program/ ; CHE-1827930/National Science Foundation/ ; R35 GM119426/GM/NIGMS NIH HHSUnited States/ ; DGE1937971/National Science Foundation/ ; CC/CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:da84f235788b4d67d19c0b52643964659c188491f7100eec26ca9a0e57e92f2d
File Type:

Supporting Files

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