Details:

Alternative Title:
Ann Work Expo Health
Publisher's site:
http://dx.doi.org/10.1093/annweh/wxx037
Personal Author:
LeBouf, Ryan F. ; Virji, Mohammed Abbas ; Ranpara, Anand ; Stefaniak, Aleksandr B.
LeBouf, Ryan F. ; Virji, Mohammed Abbas ; Ranpara, Anand ; Stefaniak, Aleksandr B. Less -
Description:
This method was designed for sampling select quaternary ammonium (quat) compounds in air or on surfaces followed by analysis using ultraperformance liquid chromatography tandem mass spectrometry. Target quats were benzethonium chloride, didecyldimethylammonium bromide, benzyldimethyldodecylammonium chloride, benzyldimethyltetradecylammonium chloride, and benzyldimethylhexadecylammonium chloride. For air sampling, polytetrafluoroethylene (PTFE) filters are recommended for 15-min to 24-hour sampling. For surface sampling, Pro-wipe® 880 (PW) media was chosen. Samples were extracted in 60:40 acetonitrile:0.1% formic acid for 1 hour on an orbital shaker. Method detection limits range from 0.3 to 2 ng/ml depending on media and analyte. Matrix effects of media are minimized through the use of multiple reaction monitoring versus selected ion recording. Upper confidence limits on accuracy meet the National Institute for Occupational Safety and Health 25% criterion for PTFE and PW media for all analytes. Using PTFE and PW analyzed with multiple reaction monitoring, the method quantifies levels among the different quats compounds with high precision (<10% relative standard deviation) and low bias (<11%). The method is sensitive enough with very low method detection limits to capture quats on air sampling filters with only a 15-min sample duration with a maximum assessed storage time of 103 days before sample extraction. This method will support future exposure assessment and quantitative epidemiologic studies to explore exposure-response relationships and establish levels of quats exposures associated with adverse health effects.
Subject:
[+]
Article Cleaning Products Liquid Chromatography Tandem Mass Spectrometry Quaternary Ammonium Compounds Sampling And Analysis Methods
Source:
Ann Work Expo Health. 61(6):724-736.
Pubmed ID:
28927165
Pubmed Central ID:
PMC5826613
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:31fa872da22ee4e69259851339a55e220c7604998e482181942b3a6b296261b6
Download URL:
https://stacks.cdc.gov/view/cdc/52135/cdc_52135_DS1.pdf
File Type:

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