Trajectories in Estimated Glomerular Filtration Rate in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Diabetes Complications
• Personal Author:
  Westreich, Katherine D. ; Isom, Scott ; Divers, Jasmin ; D’Agostino, Ralph ; Lawrence, Jean M. ; Shankar, Roopa Kanakatti ; Dolan, Lawrence M. ; Imperatore, Giuseppina ; Dabelea, Dana ; Mayer-Davis, Elizabeth J. ; Mottl, Amy K.
• Description:
  Aims:
  
  We sought to characterize the direction and associated factors of eGFR change following diagnosis of youth-onset type 1 and type 2 diabetes.
  
  Methods:
  
  We assessed the direction of eGFR change at two visits (mean 6.6 years apart) in SEARCH, a longitudinal cohort study of youth-onset type 1 and type 2 diabetes. We used the CKiDCr-CysC equation to estimate GFR and categorized ‘rising’ and ‘declining’ eGFR as an annual change of ≥3ml/min/1.73m2 in either direction. Multivariable logistic regression evaluated factors associated with directional change in eGFR.
  
  Results:
  
  Estimated GFR declined in 23.8% and rose in 2.8% of participants with type 1 diabetes (N=1225; baseline age 11.4 years), and declined in 18.1% and rose in 15.6% of participants with type 2 diabetes (N=160; baseline age 15.0 years). Factors associated with rising and declining eGFR (versus stable) in both type 1 and type 2 diabetes included sex, age at diagnosis, baseline eGFR and difference in fasting glucose between study visits. Additional factors in type 1 diabetes included time from baseline visit, HbA1c and body mass index.
  
  Conclusions:
  
  Over the first decade of diabetes, eGFR decline is more common in type 1 diabetes whereas eGFR rise is more common in type 2 diabetes.
  
  
• Subjects:
  Adolescent Child Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Nephropathies Disease Progression Glomerular Filtration Rate Humans Longitudinal Studies
• Keywords:
  Diabetes EGFR Kidney Longitudinal Trajectory Youth
• Source:
  J Diabetes Complications. 35(2):107768
• Pubmed ID:
  33168393
• Pubmed Central ID:
  PMC7855388
• Document Type:
  Journal Article
• Funding:
  U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000062/TR/NCATS NIH HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR002319/TR/NCATS NIH HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  35
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:fc6d46ed3f4243bc687cf59e0e410613cedbfa5aba867ad11e9d7bf98686eec177f8b299e1b4201bf5d23743a16562cfc1f4319c4682e339ea34e0afd5d678d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/102155/cdc_102155_DS1.pdf
• File Type:
  [PDF - 433.60 KB ]