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Trajectories in Estimated Glomerular Filtration Rate in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study
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2 2021
Source: J Diabetes Complications. 35(2):107768 -
Alternative Title:J Diabetes Complications
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Personal Author:
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Description:Aims:
We sought to characterize the direction and associated factors of eGFR change following diagnosis of youth-onset type 1 and type 2 diabetes.
Methods:
We assessed the direction of eGFR change at two visits (mean 6.6 years apart) in SEARCH, a longitudinal cohort study of youth-onset type 1 and type 2 diabetes. We used the CKiDCr-CysC equation to estimate GFR and categorized ‘rising’ and ‘declining’ eGFR as an annual change of ≥3ml/min/1.73m2 in either direction. Multivariable logistic regression evaluated factors associated with directional change in eGFR.
Results:
Estimated GFR declined in 23.8% and rose in 2.8% of participants with type 1 diabetes (N=1225; baseline age 11.4 years), and declined in 18.1% and rose in 15.6% of participants with type 2 diabetes (N=160; baseline age 15.0 years). Factors associated with rising and declining eGFR (versus stable) in both type 1 and type 2 diabetes included sex, age at diagnosis, baseline eGFR and difference in fasting glucose between study visits. Additional factors in type 1 diabetes included time from baseline visit, HbA1c and body mass index.
Conclusions:
Over the first decade of diabetes, eGFR decline is more common in type 1 diabetes whereas eGFR rise is more common in type 2 diabetes.
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Pubmed ID:33168393
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Pubmed Central ID:PMC7855388
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