Testicular organoids to study cell-cell interactions in the mammalian testis

Sakib, Sadman; Goldsmith, Taylor; Voigt, Anna; Dobrinski, Ina

i

Testicular organoids to study cell-cell interactions in the mammalian testis

Supporting Files

July 2020
By Sakib, Sadman ; Goldsmith, Taylor ; Voigt, Anna ; ...

File Language:

English

Details

Alternative Title:

Andrology
Personal Author:

Sakib, Sadman ; Goldsmith, Taylor ; Voigt, Anna ; Dobrinski, Ina
Description:

Background:

Over the last ten years, three-dimensional organoid culture has garnered renewed interest, as organoids generated from primary cells or stem cells with cell associations and functions similar to organs in vivo can be a powerful tool to study tissue-specific cell-cell interactions in vitro. Very recently, a few interesting approaches have been put forth for generating testicular organoids for studying the germ cell niche microenvironment.

Aim:

To review different model systems that have been employed to study germ cell biology and testicular cell-cell interactions and discuss how the organoid approach can address some of the shortcomings of those systems.

Results and Conclusion:

Testicular organoids that bear architectural and functional similarities to their in vivo counterparts, are a powerful model system to study cell-cell interactions in the germ cell niche. Organoids enable studying samples in humans and other large animals where in vivo experiments are not possible, allow modeling of testicular disease and malignancies and may provide a platform to design more precise therapeutic interventions.
Subjects:

Animals Article Cell-cell Interaction Cell Communication Cell Culture Techniques Germ Cell Niche Humans Male Morphogenesis Organoids Testicular Organoids Testis
Source:

Andrology. 8(4):835-841
Pubmed ID:

31328437
Pubmed Central ID:

PMC7786437
Document Type:

Journal Article
Funding:

R01 HD091068/HD/NICHD NIH HHSUnited States/ ; R01 OD016575/OD/NIH HHSUnited States/ ; R01 OD016575/CD/ODCDC CDC HHSUnited States/
Volume:

8
Issue:

4
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:24c5d590a72f480bd1ba7a2553a187464c0f9663e420efceb82e5d4ab11b0158
Download URL:

https://stacks.cdc.gov/view/cdc/100241/cdc_100241_DS1.pdf
File Type:

[PDF - 954.58 KB ]

File Language:

English

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