Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG

Schwarzkopf, Sina; Krawczyk, Adalbert; Knop, Dietmar; Klump, Hannes; Heinold, Andreas; Heinemann, Falko M.; Thümmler, Laura; Temme, Christian; Breyer, Marianne; Witzke, Oliver; Dittmer, Ulf; Lenz, Veronika; Horn, Peter A.; Lindemann, Monika

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Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG

Published Date:

January 2021

Source:

Emerg Infect Dis. 27(1):122-129

[PDF-1.05 MB]

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Alternative Title:

Emerg Infect Dis

Personal Author:

Schwarzkopf, Sina ; Krawczyk, Adalbert ; Knop, Dietmar ; Klump, Hannes ; Heinold, Andreas ; ... More ▼

Description:

We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2. We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using interferon-γ ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells.

Subject:

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Pubmed Central ID:

PMC7774536

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG

Cellular Immunity in COVID-19 Convalescents with PCR-Confirmed Infection but with Undetectable SARS-CoV-2–Specific IgG

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