Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Schwarzkopf, Sina ; Krawczyk, Adalbert ; Knop, Dietmar ; Klump, Hannes ; Heinold, Andreas ; ... More +
Schwarzkopf, Sina ; Krawczyk, Adalbert ; Knop, Dietmar ; Klump, Hannes ; Heinold, Andreas ; Heinemann, Falko M. ; Thümmler, Laura ; Temme, Christian ; Breyer, Marianne ; Witzke, Oliver ; Dittmer, Ulf ; Lenz, Veronika ; Horn, Peter A. ; Lindemann, Monika Less -
Description:
We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2. We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using interferon-γ ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells.
Subjects:
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B Cells Cellular Immunity Cellular Immunity In COVID-19 Convalescents With PCR-Confirmed Infection But With Undetectable SARS-CoV-2–Specific IgG Convalescent Plasma Coronavirus Disease COVID-19 ELISpot PCR-confirmed Infection Research Respiratory Infections SARS SARS-CoV-2 Seronegativity Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Coronavirus 2 T Cells Viruses Zoonoses
Source:
Emerg Infect Dis. 27(1):122-129
Pubmed Central ID:
PMC7774536
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:0e806cc907d6604dbb80f4f1ff7696915d71ba222bc376309c31609f65f8afdf
Download URL:
https://stacks.cdc.gov/view/cdc/100005/cdc_100005_DS1.pdf
File Type:

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