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R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts

CITE Title : R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts Personal Author(s) : Liu, Zhiyan Silvia;Sinha, Sayantani;Bannister, Maxwell;Song, Axia;Arriaga-Gomez, Erica;McKeeken, Alexander J.;Bonner, Elizabeth A.;Hanson, Benjamin K.;Sarchi, Martina;Takashima, Kouhei;Zong, Dawei;Corral, Victor M.;Nguyen, Evan;Yoo, Jennifer;Chiraphapphaiboon, Wannasiri;Leibson, Cassandra;McMahon, Matthew C.;Rai, Sumit;Swisher, Elizabeth M.;Sachs, Zohar;Chatla, Srinivas;Stirewalt, Derek L.;Deeg, H. Joachim;Skorski, Tomasz;Papapetrou, Eirini P.;Walter, Matthew J.;Graubert, Timothy A.;Doulatov, Sergei;Lee, Stanley C.;Nguyen, Hai Dang; Published Date : 2 15 2024;2-15-; Source : Cancer Res. 84(4):577-597 URL : https://stacks.cdc.gov/view/cdc/151645 Liu, Zhiyan Silvia et al. (2024). R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts. 84(4). Liu, Zhiyan Silvia et al. "R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts" 84, no. 4 (2024) Liu, Zhiyan Silvia et al. "R-loop accumulation in spliceosome mutant leukemias confers sensitivity to PARP1 inhibition by triggering transcription-replication conflicts" vol. 84, no. 4, 2024 Export RIS Citation Information.

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Liu, Zhiyan Silvia ;

Sinha, Sayantani

2 15 2024 | Cancer Res. 84(4):577-597

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RNA splicing factor (SF) gene mutations are commonly observed in patients with myeloid malignancies. Here we showed that SRSF2- and U2AF1-mutant leuke...

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