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Showing 921 - 940 of 83631 results
  • Characterization of PFASContaining Aqueous FilmForming Foams and Their Thermal Degradation Products Implication for Human and Environmental Health
    Characterization of PFAS-Containing Aqueous Film-Forming Foams and Their Thermal Degradation Products: Implication for Human and Environmental Health
    Bhandari, Shristi ;
    Biswas, Kousick
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):245-246 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Per- and poly-fluoroalkyl substances (PFAS) have emerged as a major environmental health problem of our time. Aqueous Film-Forming Foams (AFFF) are traditional firefighter foams based on PFAS and a major source of PFAS environmental pollution. The main focus of this study was to analyze the chemical composition and thermal d ...
    Public Domain
  • Inhalation of 3D Printing Exhaust Using Fluorescent ABS Filament Modulates Respiratory Immune Response
    Inhalation of 3D Printing Exhaust Using Fluorescent ABS Filament Modulates Respiratory Immune Response
    Chapman, P. D. ;
    McKinney, Walter G.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):251-252 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Additive manufacturing (3D printing) using thermally extruded plastics has enabled industries to innovate the process of fabrication to produce consumer products. 3D printers use a variety of plastics, colors, and dyes and has become increasingly popular in workplaces, schools and private residences over the past decade. Rec ...
    Public Domain
  • Exposure and In Vitro Hazard Characterization of Microplastic Dusts Released from Machining of Boron Nitride NanotubeEnabled Composites Along Its Lifecycle
    Exposure and In Vitro Hazard Characterization of Microplastic Dusts Released from Machining of Boron Nitride Nanotube-Enabled Composites Along Its Lifecycle
    Stueckle, Todd A. ;
    Kim, S. H.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):464 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Boron nitride nanotubes possess unique electrical insulation and radiation shielding abilities for use in light weight ceramics and flame-retardant insulation applications. Enabling plastic and epoxy resin composites with nanomaterials can affect technological performance and particle release characteristics during use scena ...
    Public Domain
  • Neuroendocrine Effects of Inhaling Emissions Generated by 3Dimensional 3D Printing with Polycarbonate Stock
    Neuroendocrine Effects of Inhaling Emissions Generated by 3-Dimensional (3D) Printing with Polycarbonate Stock
    Krajnak, Kristine M. ;
    Mandler, W. Kyle
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):395 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Inhalation of emissions (particulate and volatile chemicals) generated while 3D printing with polycarbonate feedstock results in the deposition of bisphenol A (BPA) in the respiratory system and affects reproductive function and circulating concentrations of anterior pituitary hormones and gonadal steroids in rats exposed to ...
    Public Domain
  • Elucidating the Role of IL5 in the Pulmonary Response to Inhalation of Aspergillus versicolor and Stachybotrys chartarum Using a Murine IL5 Knockout Model
    Elucidating the Role of IL-5 in the Pulmonary Response to Inhalation of Aspergillus versicolor and Stachybotrys chartarum Using a Murine IL-5 Knockout Model
    Weaver, K. L.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):252 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: A changing climate has resulted in an increased frequency and severity of hurricanes and flooding that devastate communities and leave structures inundated with water. Water damage in buildings promotes growth of fungal species that can be harmful to human health. This is of concern given that humans spend over 90% of their ...
    Public Domain
  • Lung Toxicity Profile of Inhaled CopperNickel Welding Fumes in Rats
    Lung Toxicity Profile of Inhaled Copper-Nickel Welding Fumes in Rats
    Zeidler-Erdely, Patti C. ;
    Roberts, Jennifer R.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):253 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Welding processes create inhalable fumes rich in iron (Fe) that may also contain known toxic metals such as chromium (Cr) and nickel (Ni). Welding aerosols derived from copper-nickel (CuNi) consumables have not been investigated as thoroughly as those from mild (Fe-rich) and stainless-steel (Fe-rich + Cr + Ni) welding consum ...
    Public Domain
  • Characterization of Particles Generated by a Novel Powder Flame Thermal Spray Coating System
    Characterization of Particles Generated by a Novel Powder Flame Thermal Spray Coating System
    Afshari, Aliakbar A. ;
    McKinney, Walter G.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):257 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Flame Thermal spray coating (FTSC) is a process where a mixture of metal and ceramic coating powder is melted at high temperatures and sprayed onto a surface using air pressure. This creates a complex aerosol containing various elements, such as copper, chromium, nickel, zinc, and aluminum. However, there is limited informat ...
    Public Domain
  • Lung Response to Crystalline Silica and Coal Dust Exposure in Rats
    Lung Response to Crystalline Silica and Coal Dust Exposure in Rats
    Joseph, Pius ;
    McKinney, Walter G.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):574 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: The passage of the Federal Coal Mine Health and Safety Act (Coal Act) in 1969, along with the establishment of the Coal Workers Health Surveillance Program (CWHSP) managed by the National Institute for Occupational Safety and Health (NIOSH) in association with the Mine Safety and Health Administration (MSHA), significantly r ...
    Public Domain
  • Gene Expression Changes in the Lung Following Exposure to Different Forms of Graphenes
    Gene Expression Changes in the Lung Following Exposure to Different Forms of Graphenes
    Sager, Tina M. ;
    Eye, Tracy
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):703 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Nanostructured materials display interesting and valuable properties. This has sparked a massive expansion in the production and use of engineered nanomaterials over the last 20 years. Due to this expansion, there is a need to assess the hazards of exposure to such materials to gain insight on their potential harm to human h ...
    Public Domain
  • CrossSeasonal Changes in the Levels of Inflammatory Biomarkers Among Wildland Firefighters
    Cross-Seasonal Changes in the Levels of Inflammatory Biomarkers Among Wildland Firefighters
    Wu, C. ;
    Clark, K.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):604 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Wildfire activity is increasing in frequency and severity across the United States. Wildland firefighters are the first line of defense against this disaster situation. During firefighting, wildland firefighters are directly exposed to elevated levels of smoke. Exposure to air pollutants from wildland fire smoke, such as res ...
    Public Domain
  • Impact of Stress Hormone on Brain Damage and Inflammatory Responses Resulting from Methamphetamine Exposure in Rats
    Impact of Stress Hormone on Brain Damage and Inflammatory Responses Resulting from Methamphetamine Exposure in Rats
    Michalovicz, Lindsay T. ;
    Billig, Brenda K.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):617-618 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Over the last several years, illicit drug use has increased in the U.S. including drugs like methamphetamine. As a dopaminergic neurotoxicant, methamphetamine exposure poses risk of injury to dopaminergic neurons, brain inflammation, and mortality. While illicit drug use constitutes an obvious health risk to the user, public ...
    Public Domain
  • Evaluating the Relationship Between Nano and Microplastic Size and Composition in Pulmonary Genotoxicity and Inflammation In Vitro
    Evaluating the Relationship Between Nano and Microplastic Size and Composition in Pulmonary Genotoxicity and Inflammation In Vitro
    Fraser, Kelly ;
    Aldinger, Jeffrey A.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):465-466 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Nano and Microplastics are an environmental and occupational health concern due to the rapidly growing industry predicted to result in the production of over 34 billion tons of plastic by 2050. Recently, studies have found increasing concentrations of micro and nano sized plastic particles in the environment, including in th ...
    Public Domain
  • Inflammatory Impacts of TireRelated Particles Do All Roads Lead to Rome
    Inflammatory Impacts of Tire-Related Particles: Do All Roads Lead to Rome?
    Wehle, B. ;
    Li, Y.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):483 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Current air pollution regulations focus entirely on exhaust emissions. However, inhalation of tire wear particles (TWP), produced when tires are worn down in contact with the road surface, could pose an emerging threat to human health. The environmental burden of TWP is expected to increase in coming years as more consumers ...
    Public Domain
  • 44Methylene Diphenyl DiisocyanateGlutathione Conjugate Exposure Downregulates Endogenous HsamiR3813p Through Induction of Circular RNA hsa_circ_0099188 in Macrophages
    4,4′-Methylene Diphenyl Diisocyanate-Glutathione Conjugate Exposure Downregulates Endogenous Hsa-miR-381-3p Through Induction of Circular RNA hsa_circ_0099188 in Macrophages
    Lin, C. ;
    Law, Brandon F.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):470 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Exposure to 4,4'-methylene diphenyl diisocyanate (MDI), the most widely used monomeric diisocyanate, in the occupational setting may lead to the development of occupational asthma (OA). Currently, the underlying molecular mechanism(s) by which MDI induces OA have yet to be elucidated. Alveolar macrophage (MØ) dysfunction pla ...
    Public Domain
  • The Transcription Factor PU1 Mediates MultiWalled Carbon NanotubesInduced Arachidonate 5Lipoxygenase Expression and Proinflammatory Responses in Macrophages
    The Transcription Factor PU.1 Mediates Multi-Walled Carbon Nanotubes-Induced Arachidonate 5-Lipoxygenase Expression and Proinflammatory Responses in Macrophages
    Lim, C. ;
    Gu, Ja K.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):466 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Exposure to fibrogenic multi-walled carbon nanotubes (MWCNTs) induces the production of proinflammatory lipid mediators (LMs) in myeloid cells to instigate inflammation. The molecular underpinnings of LM production in nanotoxicity remain unclear. Methods: Murine (J774A.1 cells) or human monocyte derived macrophages were trea ...
    Public Domain
  • Rapid Activation of Prostaglandin Synthesis Pathways in Mouse Lungs Exposed to MultiWalled Carbon Nanotubes
    Rapid Activation of Prostaglandin Synthesis Pathways in Mouse Lungs Exposed to Multi-Walled Carbon Nanotubes
    Ma, Qiang ;
    LeBouf, Ryan F.
    2025/03/05 | Toxicologist 2025 Mar; 204(S1):575 | National Institute for Occupational Safety and Health (NIOSH)
    Background and Purpose: Pulmonary exposure to respirable particles elicits acute inflammation with concurring tissue damage that may progress to chronic outcomes. The initiation and resolution of inflammation are critically regulated by potent proinflammatory and pro-resolving mediators in a time-dependent manner. Here we examined the synthesis of ...
    Public Domain
  • ForceInduced Tissue Compression Alters Circulating Hormone Levels and Biomarkers of Peripheral Vascular and Sensorineural Dysfunction in an Animal Model of HandArm Vibration Syndrome
    Force-Induced Tissue Compression Alters Circulating Hormone Levels and Biomarkers of Peripheral Vascular and Sensorineural Dysfunction in an Animal Model of Hand-Arm Vibration Syndrome
    Chapman P ;
    Dong, Ren G.
    2025/03/04 | National Institute for Occupational Safety and Health (NIOSH)
    Workers regularly using vibrating hand tools may develop a disorder referred to as hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms in the hands and fingers that result in blanching of the skin, loss of sensory function, pain, and reductions in manual dexterity. Exposure to vibration induces some of these symptom ...
    Public Domain Peer Reviewed
  • Nasosorption as a noninvasive approach to measure metals and metalloids in the airway by benchtop energydispersive Xray fluorescence
    Nasosorption as a non-invasive approach to measure metals and metalloids in the airway by benchtop energy-dispersive X-ray fluorescence.
    Adesina KE ;
    Lanzer JM
    2025/03/04 | National Institute for Occupational Safety and Health (NIOSH)
    Quantifying metals in samples from the respiratory tract may provide valuable insights into environmental exposure level and the associated risks to respiratory health. This study evaluates the feasibility of a novel method for quantifying metals and metalloids in the upper airway by nasosorption, in which nasal epithelial lining fluid (NELF) is co ...
    Peer Reviewed
  • Mesothelioma Risks and Cumulative Exposure to Elongate Mineral Particles of Various Sizes in Minnesota Taconite Mining Industry
    Mesothelioma Risks and Cumulative Exposure to Elongate Mineral Particles of Various Sizes in Minnesota Taconite Mining Industry
    Alexander BH ;
    MacLehose RF
    2025/03/04 | National Institute for Occupational Safety and Health (NIOSH)
    Objectives: An excess of mesothelioma has been previously observed in iron ore miners in Northeastern Minnesota. This study explored the potential association between mesothelioma and elongate mineral particle (EMP) exposures in the Minnesota taconite mining industry, examining both regulated and non-regulated EMP dimensions. Methods: A nested case ...
    Peer Reviewed
  • Navigating the Valley of Death A Brief Report on How Incubators Can Nurture Transition of Research to Practice to Benefit Worker Wellbeing
    Navigating the “Valley of Death”: A Brief Report on How Incubators Can Nurture Transition of Research to Practice to Benefit Worker Wellbeing
    Hirabayashi L ;
    Maben L
    2025/03/04 | National Institute for Occupational Safety and Health (NIOSH)
    Incubator and accelerator programs are important tools for innovators looking to take their ideas to scale. Unfortunately for agriculture, forestry, and fishing (AgFF) populations who are at high risk for occupational injuries and fatalities, few safety and health solutions have graduated from these programs. This brief report explores what it will ...
    Peer Reviewed
921 - 940 / 83631
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