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Showing 45881 - 45900 of 82972 results
  • MCP1 Is Elevated in Hippocampus After Trimethyl Tin TMTInduced Neuronal Damage Biomarker of Neural Injury
    MCP-1 Is Elevated in Hippocampus After Trimethyl Tin (TMT)-Induced Neuronal Damage: Biomarker of Neural Injury?
    Little AR ;
    O'Callaghan JP
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Monocyte chemoattractant protein (MCP)-1, a proinflammatory chemokine, recently has been reported to be up-regulated in many models of neuronal damage, including infection, axotomy, Alzheimer's (mouse model), excitotoxicity, and traumatic brain injury. A role for this chemokine in toxic injuries of the CNS has not been established, therefore, we ev ...
    Public Domain
  • Differential Effects of 4TertOctylphenol OP 17BEstradiol E2 Bisphenol A BIS or Endosulphan ENDO on Steroidogenic Competence of Cultured Adult Rat Leydig Cells LC
    Differential Effects of 4-Tert-Octylphenol (OP), 17B-Estradiol (E2), Bisphenol A (BIS), or Endosulphan (ENDO) on Steroidogenic Competence of Cultured Adult Rat Leydig Cells (LC)
    de Leon JH ;
    Derk RC
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    In the current studies, we evaluated the effects of 4-tert-octylphenol (OP), endosulfan, bisphenol A (BPA), and 17beta-estradiol on basal or hCG-stimulated testosterone formation by cultured Leydig cells from young adult male rats. Exposure of Leydig cells to increasing concentrations of OP (1 to 2000 nM), 17beta-estradiol (1 to 1000 nM), endosulfa ...
    Public Domain
  • Mortality and Morbidity in Agriculture in the United States
    Mortality and Morbidity in Agriculture in the United States
    Rautiainen, Risto ;
    Reynolds S
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The fatal injury rate in agriculture has been essentially the same for the past decades. According to the Bureau of Labor Statistics (BLS), Census of Fatal Occupational Injuries (CFOI), 807 persons died in 1999 in the agriculture industry, which includes forestry and fishing. The injury rate was 24 fatalities per 100,000 workers. This is five times ...
  • Evaluation of the Estrogenic Activity of Octamethylcyclotetrasiloxane in B6C3F1 Mice
    Evaluation of the Estrogenic Activity of Octamethylcyclotetrasiloxane in B6C3F1 Mice
    He B ;
    Meade BJ
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Octamethylcyclotetrasiloxane (D4) is a low molecular weight cyclic silicone used in the synthesis of larger silicone polymers and the formulation of a variety of personal care products. Its biological activities are being investigated due to its widespread use. Few studies have examined the estrogenic activity of D4. In our studies, the effects of ...
    Public Domain
  • Rapid Declines in FEV1 and Subsequent Respiratory Symptoms Illnesses and Mortality in Coal Miners in the United States
    Rapid Declines in FEV1 and Subsequent Respiratory Symptoms, Illnesses, and Mortality in Coal Miners in the United States
    Beeckman LF ;
    Petsonk, Edward L.
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Coal mine dust exposure is associated with accelerated loss of lung function Weassesed long-term health outcomes in two groups of underground coal miners who during previous mine surveys had shown either high rates of FEV, decline(cases, n = 310) or relatively stable lung function(referents, n = 324). Cases and referents were matched initially for ...
    Public Domain
  • Assessment of Oxidative DNA Damage in Female Workers Exposed to Perchloroethylene
    Assessment of Oxidative DNA Damage in Female Workers Exposed to Perchloroethylene
    Butler MA ;
    Forrester C
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Although perchloroethylene (PERC) has not been found to induce oxidative stress, the major metabolites (tri- and di-chloroacetic acids) have been reported to induce lipid peroxidation and oxidative DNA damage in rodents. In the present study, oxidative DNA damage and lipid peroxidation were assessed in 38 women with or without occupational exposure ...
    Public Domain
  • Polymorphisms of the IL1 Gene Complex in Coal Miners with Silicosis
    Polymorphisms of the IL-1 Gene Complex in Coal Miners with Silicosis
    Burleson F ;
    Landsittel DP
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Silicosis is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Pro-inflammatory cytokines, such as interleukin-1 (IL-1), play a key role in the development of silicosis by regulating mediators which are responsible for lung injury, inflammation, and potentially fibrosis. To study whether functio ...
    Public Domain
  • Diesel Exhaust Particulate DEP Affected Thiol Levels in Both Alveolar Macrophages AM and Lymph Node Cells LNC
    Diesel Exhaust Particulate (DEP) Affected Thiol Levels in Both Alveolar Macrophages (AM) and Lymph Node Cells (LNC)
    Al-Humadi NH ;
    Lewis, Daniel M.
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Glutathione (GSH) and cysteine (CYS) are major intracellular antioxidants and play an important role in protecting against electrophilic xenobiotics. The purpose of this research was to study the thiol regulation by AM and LNC, and the effect of DEP on this process. AM, and thymic and tracheal lymph node lymphocytes were obtained from rats 3 days a ...
    Public Domain
  • Toxic Response Following Latex Drain Implantation
    Toxic Response Following Latex Drain Implantation
    Hubbs A ;
    Meade BJ
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    These studies were initiated to investigate the potential role of implanting latex surgical drains on the development of latex allergy. Protein and allergen levels of 5 different brands of Penrose drains were quantified by the Lowry method and an immunoassay. Protein values ranged from 44 to 2566 ng/mg drain material, and latex allergen ranged from ...
    Public Domain
  • Health Hazard Evaluation Report HETA 200002622833 Southern Supply Manufacturing Company Inc St Petersburg Florida
    Health Hazard Evaluation Report: HETA 2000-0262-2833: Southern Supply & Manufacturing Company, Inc., St. Petersburg, Florida
    Harney, Joshua M. ;
    Trout, Douglas B.
    2001/03/01 | Health Hazard Evaluation Reports (HHE)
    In April 2000, the National Institute for Occupational Safety and Health (NIOSH) received a management request for a Health Hazard Evaluation (HHE) at the Southern Supply & Manufacturing Company, Inc. in St. Petersburg, Florida. Southern Supply & Manufacturing Co., Inc. manufactures shears, scissors, and thread nippers for the garment, textile, and ...
    Public Domain
  • Lung Area Volume Models in Relation to the Recruitment Derecruitment of Individual Lung Units
    Lung Area – Volume Models in Relation to the Recruitment – Derecruitment of Individual Lung Units
    Brancazio L ;
    Franz GN
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The objective of this study was to reconsider some of the previous experimental results in terms of simple geometric models in order to determine if any of the apparent conflicts could be explained within a more unified concept. These models allow individual lung units and the entire lung to expand differently with regard to their area-volume relat ...
    Public Domain
  • Human Interindividual Variance of Cytochrome P450 and Microsomal Protein in Liver
    Human Interindividual Variance of Cytochrome P450 and Microsomal Protein in Liver
    Lipscomb JC ;
    Snawder, John E.
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The application of physiologically based phatmacokinetic (PBPK) modeling allows the tissue specific concentration of xenobiotics to be estimated for application in human health risk assessment. The impact of metabolic variance on the pharmacokinetics of environmental toxicants can be estimated by accurately quantifying the expression of the pertine ...
    Public Domain
  • Tumorigenic Potential of Metal Working Fluid Induced in BALBC3T3 Transformed Cells
    Tumorigenic Potential of Metal Working Fluid Induced in BALB/C-3T3 Transformed Cells
    Chen ZY ;
    Huffman D
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Occupational exposures to Metal Working Fluids (MWF) occur in a variety of settings. Workers are exposed to MWF through skin contact and by handling parts, tools and equipment covered with MWF. Our earlier studies indicate that MWF is capable of transforming BALB/c-3T3 cells. Further, studies were performed to identify the tumorigenic potential, if ...
    Public Domain
  • Inhibition of LPSInduced TNFX Expression by Phenolic Antioxidants
    Inhibition of LPS-Induced TNF-X Expression by Phenolic Antioxidants
    Kinneer DeFede K ;
    Luster M
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Phenolic antioxidants exhibit anti-inflammatory, anti-atherosclerotic, and anti-carcinogenic activities in animals. The broad range of biological effects of the phenolic antioxidants suggests multiple mechanisms exist for their action. Tumor necrosis factor alpha (TNF-alpha) is an important regulator of immune and inflammatory responses and tumor g ...
    Public Domain
  • Evaluation of IL9 IL10 IL13 and IL15 as Biomarkers of Dermal Exposure to Respiratory Sensitizers
    Evaluation of IL-9, IL-10, IL-13 and IL-15 as Biomarkers of Dermal Exposure to Respiratory Sensitizers
    Manetz TS ;
    Meade BJ
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Differential modulation of mRNA and protein levels for interleukin-4 (IL-4), IL10 and interferon gamma by respiratory and T cell mediated sensitizers has been demonstrated. The following investigation examined the mRNA expression patterns of multiple cytokines associated with respiratory sensitization for modulation using a Multiprobe Ribonuclease ...
    Public Domain
  • Occupational Health Graduate Training Program
    Occupational Health Graduate Training Program
    Samimi B
    2001/03/01 | Grant Final Reports
    The purpose of this program is to continue training graduates with a Master's of Science degree in Industrial Hygiene Concentration. The program of study includes 42 semester units of graduate work including 6 units of core courses in epidemiology and biostatistics, 20 units of specialization courses in industrial hygiene and 16 units of electives, ...
  • Evaluation of the Dermal Sensitization Potential of 3Amino5Mercapto12 4Triazole and N26Difluorophenyl5methyl12 4 Triazolo15aPyrimidine2Sulfonamide
    Evaluation of the Dermal Sensitization Potential of 3-Amino-5-Mercapto-1,2, 4-Triazole and N-(2,6-Difluorophenyl)-5-methyl)1,2, 4) Triazolo-(1,5a)-Pyrimidine-2-Sulfonamide
    Klink KJ ;
    Meade BJ
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    3-Amino-5-mercapto-l,2,4-triawle (AMT) is an intermediate used in the production of the herbicide. N-(2,6-Difluorophenyl)-5-methyl)1,2,4) triazolo-(l,5a)pyrimidine-2-sulfonamide (DE498), and has been listed by the EPA as a chemical needing further toxicity testing. These studies focus on evaluating the immunomodulatory effects of AMT and DE498 usin ...
    Public Domain
  • Transcriptional Regulation of TIG1 a Novel TCDDInducible Gene by the Aryl Hydrocarbon Receptor
    Transcriptional Regulation of TIG1, a Novel TCDD-Inducible Gene, by the Aryl Hydrocarbon Receptor
    Baldwin K ;
    Ma Q
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    TCDD (2,3,7,8-teuachlorodibenzo-p-dioxin) is the prototype of a class of structurally related halogenated aromatic hydrocatbons. TCDD elicits a wide range of responses in animals and may pose a threat to human health. The aryl hydrocarbon receptor is a ligand-activated receptor/transcription factor, which, together with Arm and other factors, media ...
    Public Domain
  • Histopathologic Assessment of Acute Dermal Exposure to MetaXylene in Rats and Guinea Pigs
    Histopathologic Assessment of Acute Dermal Exposure to Meta-Xylene in Rats and Guinea Pigs
    Brinkley WW ;
    Garrett CM
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Irritation by organic chemicals and solvents is not well understood due to the complex interplay of multiple, simultaneous molecular interactions leading to acute change. Histopathology provides a valid and verifiable reference point in this changing microenvironment. Rats are often used as experimental animals for the study of toxic mechanisms and ...
  • IL4 Fails to Regulate In Vitro BerylliumInduced Cytokines in Berylliosis
    IL-4 Fails to Regulate In Vitro Beryllium-Induced Cytokines in Berylliosis
    Balkissoon R ;
    Barker EA
    2001/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Bronchoalveolar lavage (BAL) cells from patients with chronic beryllium disease (CBD) have been used to evaluate the beryllium-specific immune response and potential immunotherapeutics. Beryllium induces interferon-y (IFN-y), interleukin-2 (IL-2), tumour necrosis factor-a (TNF-a), interleukin-6 (IL-6) and interleukin-10 (IL-10) from BAL cells. An a ...
    Public Domain
45881 - 45900 / 82972