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Showing 44301 - 44320 of 82803 results
  • Interaction of Ah Receptor with Phenolic Antioxidant Signal Transduction
    Interaction of Ah Receptor with Phenolic Antioxidant Signal Transduction
    Burdette H ;
    Denison M
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The aryl hydrocarbon receptor (AhR) mediates a spectrum of adaptive and toxic responses to the environmental contaminant TCDD and related halogenated aromatic hydrocarbons. AhR may also playa role(s) in development, growth, and differentiation of tissues in the absence of an exogenous ligand. The broad range of TCDD toxicity and AhR function sugges ...
    Public Domain
  • Autoantibodies to Nervous System Proteins Following Trimethyl Tin TMT Exposure A Comparison of ELISA and WesternBlot Analysis
    Autoantibodies to Nervous System Proteins Following Trimethyl Tin (TMT) Exposure: A Comparison of ELISA and Western-Blot Analysis
    Clerval CD ;
    DeFeo AP
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Previous studies in both human and animals have demonstrated the presence of serum autoantibodies to neurotypic [e.g., neurofilament triplet (NF)] and gliotypic proteins [myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP)] following exposure to some heavy metals, solvents, or pesticides. TMT has been used as a denervation tool to ...
    Public Domain
  • Is There a Relationship Between Urinary and Leukocyte 8Hydroxydeoxyguanosine in Humans
    Is There a Relationship Between Urinary and Leukocyte 8-Hydroxydeoxyguanosine in Humans?
    Butler MA ;
    DeBord, D. Gayle
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    8-Hydoxydeoxyguanosine (8-OHdG) is typically measured in DNA of white blood cells (WBCs) or in urine. Urine measurement is believed to provide an index of oxidative DNA damage repair. WBCs are considered a surrogate for target tissues. These markers are used almost interchangeably to assess the adverse effects of a variety of environmental factors. ...
    Public Domain
  • The Minnesota Health Partnership and Coordinated Health Care and Disability Prevention The Implementation of an Integrated Benefits and Medical Care Model
    The Minnesota Health Partnership and Coordinated Health Care and Disability Prevention: The Implementation of an Integrated Benefits and Medical Care Model
    Calasanz M ;
    Christianson J
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    In the spring of 1996, the Minnesota Health Partnership (MHP) received a demonstration grant from the Robert Wood Johnson Foundation Workers Compensation Health Initiative to pilot a model of health care that was designed to combine the best practices of general health and workers' compensation medical care. This paper outlines the genesis of the M ...
  • Size Distribution and Diurnal and Seasonal Trends of Ultrafine Particles in Source and Receptor Sites of the Los Angeles Basin
    Size Distribution and Diurnal and Seasonal Trends of Ultrafine Particles in Source and Receptor Sites of the Los Angeles Basin
    Hinds WC ;
    Kim S
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    This paper presents results from a study conducted in two urban areas of southern California, Downey and Riverside, to examine the effect of different sources and formation mechanisms on the size distribution and temporal trends of ultrafine particles. Near-continuous data were collected for 5 months at each location. Our data clearly identified Do ...
  • An Assessment of the Use of Dimethyl Sulfoxide as a Solvent for Hydrophobic Chemicals in a DrosophilaBased Developmental Toxicity Prescreen
    An Assessment of the Use of Dimethyl Sulfoxide as a Solvent for Hydrophobic Chemicals in a Drosophila-Based Developmental Toxicity Prescreen
    Lynch DW
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Dimethyl sulfoxide (DMSO) is routinely used in toxicity testing to solubilize hydrophobic chemicals; however, the potential of DMSO to induce developmental toxicity in the Drosophila-based prescreen has not been well characterized. The purpose of this study was to investigate this toxicity and to determine a maximum concentration of DMSO which can ...
    Public Domain
  • Hearing Protector Use in Noise Exposed Workers A Retrospective Look at 1983
    Hearing Protector Use in Noise Exposed Workers: A Retrospective Look at 1983
    Davis, Rickie R. ;
    Sieber, W. Karl
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Although hearing protectors have been available for more than 60 years, little field surveillance has been done to assess their appropriate wear in noisy occupational environments. This study examined historical field survey data to determine whether workers use hearing protection when exposed to loud noise. Data from the 1981-83 NIOSH National Occ ...
    Public Domain
  • Role of Apoptosis Induction in Development of Lung Injury from High Burdens of Titanium Dioxide
    Role of Apoptosis Induction in Development of Lung Injury from High Burdens of Titanium Dioxide
    Antonini J ;
    Castranova, Vincent
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    We previously examined the role of apoptosis in lung pathology due to silica, a highly toxic particle and demonstrated that apoptotic cells and degradation products significantly accumulate as injury develops. In this study we test the hypothesis that titanium dioxide (TiO2), a particle with no known specific toxicity, induces apoptosis and accumul ...
    Public Domain
  • The Recognition and Management of WorkAggravated Asthma
    The Recognition and Management of Work-Aggravated Asthma
    Filios, Margaret S. ;
    Goe, Sandra D.
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Pre-existing asthma that is exacerbated by workplace exposures, or work-aggravated asthma, is a serious but often preventable occupational lung condition that may lead to chronic impairment if it remains unrecognized and untreated. (I) The National Institute for Occupational Safety and Health (NIOSH) funds surveillance activities for work-related a ...
  • Antisense Inhibition of Translation Elongation Factor1 Delta Reverses the Oncogenic Potential of Cadmium Transformed Cells
    Antisense Inhibition of Translation Elongation Factor-1 Delta Reverses the Oncogenic Potential of Cadmium Transformed Cells
    Joseph P ;
    Lei Y
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The molecular mechanisms of carcinogenesis induced by the human carcinogen-cadmium, were investigated. Differential display analysis of gene expression revealed the overexpression of translation elongation factor-1 delta sub-unit in BALB/c-3T3 cells transformed with cadmium chloride compared with the non- transformed control cells. cDNA cloning (Ge ...
    Public Domain
  • Selecting Isocyanate Sampling and Analytical Methods
    Selecting Isocyanate Sampling and Analytical Methods
    Cassinelli, Mary E. ;
    Key-Schwartz, Rosa J.
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Isocyanate-containing compounds are used in the production of a wide variety of surface coatings, polyurethane foams, adhesives, resins, elastomers, binders, and sealants. Examples of potential worker exposures to isocyanates in automobile painting and mining applications are shown in Figure 1. Selecting the most appropriate sampling and analytical ...
    Public Domain
  • Health Hazard Evaluation Report HETA 200001682871 Nassau Community College Garden City New York
    Health Hazard Evaluation Report: HETA #2000-0168-2871: Nassau Community College, Garden City, New York
    Park, Ju-Hyeong ;
    Schleiff, Patricia L.
    2002/03/01 | Health Hazard Evaluation Reports (HHE)
    Nassau Community College (NCC), located in Garden City, New York, is the largest two-year community college in the State of New York, employing over 1,200 full time faculty and staff in 40 different buildings on a 225 acre campus. On February 29, 2000, the National Institute for Occupational Safety and Health (NIOSH) received a formal request to co ...
    Public Domain
  • Effects of Welding Fumes on Lung Injury and Inflammation The Possible Role of Free Radical Production
    Effects of Welding Fumes on Lung Injury and Inflammation: The Possible Role of Free Radical Production
    Antonini JM ;
    Leonard, Stephen S.
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    The goals of this study were to examine lung damage and inflammation as well as free radical production caused by welding fumes of different composition. Fume was collected during flux-covered manual metal arc welding using a stainless steel consumable electrode (MMA-SS) and gas metal arc welding using a mild steel electrode (GMA-MS) or a stainless ...
    Public Domain
  • Certified equipment list as of March 31 2002
    Certified equipment list as of March 31, 2002.
    National Institute for Occupational Safety and Health
    2002/03/01 | NIOSH Numbered Publications
    The National Institute for Occupational Safety and Health, under the authorization of the Federal Mine Safety and Health Act of 1977 and the Occupational Safety and Health Act of 1970, provides a testing approval and certification program assuring commercial availability of safe personal protective devices and reliable industrial hazard measuring i ...
    Public Domain
  • Protecting Emergency Responders Volume 1 Lessons Learned from Terrorist Attacks
    Protecting Emergency Responders: Volume 1: Lessons Learned from Terrorist Attacks
    Jackson, Brian A. ;
    Peterson, D. J.
    2002/03/01 | Protecting Emergency Responders
    Just as it has for the nation as a whole, the world in which emergency responders work has changed in fundamental ways since September 11, 2001. Members of professions already defined by their high levels of risk now face new, often unknown threats on the job. At a basic level, the September 11 terrorist events have forced emergency responders to s ...
  • The Influence of Operating Parameters on NumberWeighted Aerosol Size Distribution Generated from a Gas Metal Arc Welding Process
    The Influence of Operating Parameters on Number-Weighted Aerosol Size Distribution Generated from a Gas Metal Arc Welding Process
    Baron, Paul A. ;
    Biswas P
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    In light of recent research on the potential health problems associated with sub-micrometer aerosols, a study was conducted to determine the effect that droplet mass transfer mode, shield gas composition, and welding spatter had upon the aerosols generated from a Gas Metal Arc Welding (GMAW) Operation. The results revealed that the sub-micrometer a ...
    Public Domain
  • Comparison of Low Doses of Aged and Freshly Fractured Silica on Pulmonary Inflammation and Damage in the Rat
    Comparison of Low Doses of Aged and Freshly Fractured Silica on Pulmonary Inflammation and Damage in the Rat
    Barger M ;
    Castranova, Vincent
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Most previous studies of silica toxicity have used relatively high doses of silica. In this study, rats received by intratracheal instillation either vehicle, aged or freshly fractured silica at a dose of either 5 ug per rat once a week for 12 weeks (total dose of 60 ug) or 20 ug per rat once a week for 12 weeks (total dose of 240 ug). One week aft ...
    Public Domain
  • The Age 60 Rule Age Discrimination in Commercial Aviation
    The Age 60 Rule: Age Discrimination in Commercial Aviation
    Wilkening R
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    BACKGROUND: The Federal Aviation Administration's Age 60 Rule, promulgated in 1959, prohibits airline pilots from working in Part 121 operations once they have reached the age of 60. The Age 60 Rule remains a most contentious and politically sensitive topic, with challenges to the Rule currently mounted in both legislative and legal arenas. METHODS ...
  • Alterations in Gene Expression as a Mechanism of Toxicant
    Alterations in Gene Expression as a Mechanism of Toxicant
    Andrews G ;
    Hines R
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Over the last several years, it has become apparent that many environmental toxicants exert their effects by the activation or disruption of specific signaling pathways, ultimately resulting in alterations in gene expression. With the completion of the human genome project and the advent of many powerful new technologies, there has been a revolutio ...
    Public Domain
  • Biomarker Characterization of Asphalt Fume Exposure
    Biomarker Characterization of Asphalt Fume Exposure
    Frazer DG ;
    Goldsmith T
    2002/03/01 | National Institute for Occupational Safety and Health (NIOSH)
    Each year more than 60 million tones of asphalt are produced and used worldwide. It has been estimated that approximately two million workers were employed and potentially exposed to asphalt. Health concern from exposure to asphalt is related to its content of hazardous chemicals, such as polycyclic aromatic hydrocarbons (PAHs). The development of ...
    Public Domain
44301 - 44320 / 82803