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Showing 2341 - 2360 of 82737 results
  • Warehouse Worker Dies When Material Falling Off of Pallet Strikes Him California
    Warehouse Worker Dies When Material Falling Off of Pallet Strikes Him — California
    Chan, Jacqueline ;
    Kleinmann, Robert L. P.
    2023/03/15 | Fatality Assessment and Control Evaluation Reports (FACE)
    On May 13, 2022, a 39-year-old male warehouse worker was acting as a 'spotter' and assisting a forklift operator who was moving pallets of cased bottled water near the end of the night shift. The pallets were shrink wrapped, double stacked, and combined stood about 9 ½ feet high. As the forklift operator tried to remove the top pallet, the forks ma ...
  • Sex Differences in the Th2 LungBrain Axis Response to Aspergillus Versicolor Inhalation in C57BL6J Mice
    Sex Differences in the Th2 Lung-Brain Axis Response to Aspergillus Versicolor Inhalation in C57BL/6J Mice
    Ahmed, C. ;
    Beezhold, Donald H.
    2023/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Alzheimer's disease (AD) is a devastating form of dementia that includes a dysregulated microglial phenotype and maladaptive immune cell trafficking. Yet the identity of environmental exposures that are culpable in this disruption, and in peripheral immune responses regulating the brain remain poorly understood. Aspergillus versicolor is a common f ...
    Public Domain
  • The World Trade Center Health Program Smoking Cessation
    The World Trade Center Health Program: Smoking Cessation
    Calvert, Geoffrey M. ;
    Lilly, Gerald
    2023/03/15 | National Institute for Occupational Safety and Health (NIOSH)
    Cigarette smoking can cause and/or worsen a variety of health conditions. The U.S. Preventive Services Task Force (USPSTF) recommends that smoking cessation services be offered to all adults who currently smoke, and governmental and non-governmental professional organizations support providing these interventions to patients who smoke. The World Tr ...
    Public Domain
  • SizeResolved Field Performance of LowCost Sensors for Particulate Matter Air Pollution
    Size-Resolved Field Performance of Low-Cost Sensors for Particulate Matter Air Pollution
    Carter E ;
    L'Orange C
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Particulate matter (PM) air pollution is a major health hazard. The health effects of PM are closely linked to particle size, which governs its deposition in (and penetration through) the respiratory tract. In recent years, low-cost sensors that report particle concentrations for multiple-sized fractions (PM1.0, PM2.5, PM10) have proliferated in ev ...
  • Editorial Additive or Synergistic Impacts of Sleep Circadian Rhythm Disturbances and Other Modifiable Risk Factors on Established and Novel Plasma Biomarkers of Alzheimers Disease Pathology
    Editorial: Additive or Synergistic Impacts of Sleep, Circadian Rhythm Disturbances and Other Modifiable Risk Factors on Established and Novel Plasma Biomarkers of Alzheimer’s Disease Pathology
    Ayappa I ;
    Bubu OM
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Overall, this special topic section presents the evidence of the associations between sleepiness and neuronal injury markers, with sleepiness and amyloid levels showing possible synergistic effects on p-tau/Aß42. It also presents evidence-using WT mice models induced with chronic fragmentation-demonstrating that under conditions of sleep fragmentat ...
  • Examination of the Exposome in an Animal Model The Impact of HighFat Diet and Rat Strain on Local and Systemic Immune Markers Following Occupational Welding Fume Exposure
    Examination of the Exposome in an Animal Model: The Impact of High-Fat Diet and Rat Strain on Local and Systemic Immune Markers Following Occupational Welding Fume Exposure
    Antonini J ;
    Erdely A
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    An experimental model was designed to investigate the impact of multiple exposomal factors on susceptibility to acute lung toxicity and subsequent resolution of inflammation following an occupationally-relevant inhalation exposure. To assess the role of genetic influence, two rat strains-Sprague-Dawley (SD) and Brown Norway (BN)-were used. A high f ...
    Public Domain
  • Lung Response to Coal Dust and Crystalline Silica Exposure in Rats
    Lung Response to Coal Dust and Crystalline Silica Exposure in Rats
    Beck T ;
    Joseph P
    2023/03/14 | Mining Publications
    The role of crystalline silica in the re-emergence of coal workers pneumoconiosis reported in certain U.S. Appalachian states was investigated by employing an experimental rat model of lung toxicity. A computer-controlled, automated aerosol generation system was custom-built and employed to generate aerosols containing crystalline silica (Min-U-Sil ...
    Public Domain
  • Olfactory and Central Neurotoxicity of Occupationally Relevant Inhaled Aerosols
    Olfactory and Central Neurotoxicity of Occupationally Relevant Inhaled Aerosols
    Antonini JM ;
    Fedan, Jeffery S.
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Fine and ultrafine particles generated at the workplace can aerosolize and thus inhalation exposure is a major occupational concern. Aerosolized particles deposited in nose and/or lung can reach the brain via retrograde transport across the olfactory sensory neurons (OSNs) or through the systemic circulation. The OSNs extend into the brain from the ...
    Public Domain
  • Dissolution of Inorganic Lead Pb Compounds in Synthetic Sweat to Assess Risk of Dermal Exposure
    Dissolution of Inorganic Lead (Pb) Compounds in Synthetic Sweat to Assess Risk of Dermal Exposure
    Hudson N ;
    Maier A
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    It is estimated that over 4.53x108 kg of inorganic lead (iPb) compounds were manufactured in the U.S. in 2020. Over 1.4 million U.S. workers have dermal exposures to iPb compounds in several industries with loading of iPb on hands varying widely (0.005-16.1 µg/cm2). In vitro skin studies suggest that dermal exposures to iPb could increase blood lea ...
    Public Domain
  • How the 70kg Man Impacts NIOSHRecommended Exposure Limits
    How the 70-kg Man Impacts NIOSH-Recommended Exposure Limits
    Lucas L ;
    Whittaker C
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    This study examines the impact of assuming a single human body weight value when developing occupational exposure limits. NIOSH uses quantitative risk assessment to evaluate the risks of chemical exposures in the workplace and as a basis of its occupational exposure limits, Recommended Exposure Limits (RELs). Simplifying assumptions are a necessary ...
    Public Domain
  • Systemic Toxicity Induced by Topical Application of per and Polyfluoroalkyl Substances PFAS in a Murine Model
    Systemic Toxicity Induced by Topical Application of per- and Polyfluoroalkyl Substances (PFAS) in a Murine Model
    Anderson, Stacey E. ;
    Baur R
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Per- and polyfluoroalkyl substances (PFAS) are a class of over 5000 synthetic, structurally diverse chemicals incorporated into industrial and consumer products. These fluorinated chemicals are used in flame-retardant products, stain resistant textiles, water and grease repellent products, food packaging material, nonstick cookware, carpets, and fi ...
    Public Domain
  • Pulmonary Evaluation of WholeBody Inhalation Exposure of Polycarbonate PC Filament 3D Printer Emissions in Rats
    Pulmonary Evaluation of Whole-Body Inhalation Exposure of Polycarbonate (PC) Filament 3D Printer Emissions in Rats
    Battelli L ;
    Farcas MT
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Three-dimensional (3-D) printing is an emerging technology, and increasing evidence shows that fused filament fabrication (FFF) 3-D printing using polycarbonate (PC) filaments often releases a significant amount of ultrafine particulates (UFPs) and volatile organic compounds (VOCs). Toxicological implications of these emissions on human health stil ...
    Public Domain
  • Development of a Field Analysis Method for Metallic Aerosols in Welding Fumes
    Development of a Field Analysis Method for Metallic Aerosols in Welding Fumes
    Dydak U ;
    Klicker-Wiechmann JR
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Workers are exposed to metallic aerosols produced during manufacturing processes such as welding. Welding fumes inhaled by welders generally contain large amounts of metals like iron (Fe) and manganese (Mn) which can negatively impact worker health. Identifying the size, composition, and quantity of metallic aerosols in welding fumes is essential f ...
  • Acute Exposures to Acetone and Developing an Immediately Dangerous to Life or Health IDLH Value in Occupational Settings
    Acute Exposures to Acetone and Developing an Immediately Dangerous to Life or Health (IDLH) Value in Occupational Settings
    Chittiboyina S ;
    Edmondson M
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Acetone is a colorless water-soluble liquid that is used as an industrial solvent in chemical production. The primary route of exposure to acetone in occupational settings is inhalation. Acute exposures to acetone have been reported to elicit neurological effects, irritation, and respiratory effects, which could impair a worker's ability to escape ...
    Public Domain
  • Systematic Application of ModeofAction and Human Relevance Analysis StyreneInduced Lung Tumors in Mice
    Systematic Application of Mode-of-Action and Human Relevance Analysis: Styrene-Induced Lung Tumors in Mice
    Frank EA ;
    Meek B
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Risk assessment of human health hazards often relies on observations from animal experiments. Although exposure studies in rats and mice are a major basis for determining risk in many cases, observations made in animals do not always reflect health hazards in humans due to differences in biology. In this critical review, the mode-of-action (MOA) hu ...
    Public Domain
  • Exposure and Cancer Risks Among Structural Firefighters
    Exposure and Cancer Risks Among Structural Firefighters
    Fent K
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    This talk will summarize recent studies that have evaluated cancer incidence and mortality in structural firefighters. The speaker will further discuss the predominant exposure pathways among firefighters, and how these pathways contribute to biomarkers of exposure, with an emphasis on known or probable carcinogens. He will wrap up with a discussio ...
    Public Domain
  • Sexually Dimorphic Modifications in Placental Cyclooxygeanse Metabolites After Maternal Nanomaterial Inhalation Exposure
    Sexually Dimorphic Modifications in Placental Cyclooxygeanse Metabolites After Maternal Nanomaterial Inhalation Exposure
    Bowdridge EC ;
    Dunn AC
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Maternal nano-titanium dioxide (nano-TiO2) inhalation exposure during gestation results in decreased fetal female mass, maternal estrogen production, and placental mass. Placental function is critical during gestation due to its roles in nutrientwaste exchange and endocrine production. Adverse fetoplacental environments profoundly impact fetal grow ...
  • Toxicity and Transcriptome Comparisons of Different Firefighting Foam Exposures in Human Renal Proximal Tubule Epithelial Cells
    Toxicity and Transcriptome Comparisons of Different Firefighting Foam Exposures in Human Renal Proximal Tubule Epithelial Cells
    Beitel S ;
    Burgess J
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Firefighters have long used Military Specification aqueous film forming foams (AFFF), containing complex mixtures of per- and polyfluorinated alkyl substances (PFAS), to extinguish liquid fuel fires. Chronic disease concerns following AFFF exposure have arisen in the fire service based on elevated PFAS levels with long half lives in firefighter ser ...
    Public Domain
  • The Xanthine Oxidoreductase Inhibitor Febuxostat Protects Against Nanomaterial InhalationInduced Microvascular and Reproductive Dysfunction During Gestation
    The Xanthine Oxidoreductase Inhibitor Febuxostat Protects Against Nanomaterial Inhalation-Induced Microvascular and Reproductive Dysfunction During Gestation
    Batchelor TP ;
    Bowdridge E
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Maternal inhalation exposure to nano-TiO2 during gestation impacts litter size, pup and placental mass, and uterine microvascular reactivity. In addition, we have recently shown that maternal inhalation of nano-TiO2 during gestation results in redox imbalance in dams during late gestation. However, the mechanism linking these dysfunctions with expo ...
  • In Vivo Toxicity Comparison of Surrogate Metal Oxide Mixtures from Welding Fumes
    In Vivo Toxicity Comparison of Surrogate Metal Oxide Mixtures from Welding Fumes
    Antonini JM ;
    Betler E
    2023/03/14 | National Institute for Occupational Safety and Health (NIOSH)
    Occupational exposure to welding fumes (WF), a Group 1 carcinogen (carcinogenic to humans), is a complex metal mixture commonly composed of iron (Fe), nickel (Ni), and chromium (Cr). The objective was to assess the acute in vivo toxicity of different metal oxide combinations (Cr + Ni; Fe + Ni; Fe + Cr; Fe + Cr + Ni), in proportions representing tho ...
    Public Domain
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