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Showing 521 - 540 of 1970 results

Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020.

Botelho, Julianne Cook ;

Kato, Kayoko

April 2025 | Environmental Research, 2025, v. 270

Per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals" because of their persistence in the environment, have been used in many commercial applications since the 1940s. Of late, the detection of PFAS in drinking water throughout the United States has raised public and scientific concerns. To understand PFAS exposure trends in ...

10/09/2026

Supporting Files

Title : Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020. Personal Author(s) : Botelho, Julianne Cook;Kato, Kayoko;Wong, Lee-Yang;Calafat, Antonia M.; Published Date : April 2025 Pages in Document : 120916 (20 pdf pages) Source : Environmental Research, 2025, v. 270 DOI : https://doi.org/10.1016/j.envres.2025.120916 Journal Title : Environmental Research
Botelho, J. C., Kato, K., Wong, L. Y., & Calafat, A. M. (2025). Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020. Environmental Research, 270. https://doi.org/10.1016/j.envres.2025.120916

Botelho, Julianne Cook, Kayoko Kato, Lee-Yang Wong, and Antonia M. Calafat. "Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020." Environmental Research 270 (2025). https://doi.org/10.1016/j.envres.2025.120916.

Botelho, Julianne Cook, et al. "Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020." Environmental Research, vol. 270, 2025. Stacks. https://doi.org/10.1016/j.envres.2025.120916.
Export RIS Citation Information. TY - Journal Article AU - Botelho, Julianne Cook AU - Kato, Kayoko AU - Wong, Lee-Yang AU - Calafat, Antonia M. AB - Per- and polyfluoroalkyl substances (PFAS), also known as "forever chemicals" because of their persistence in the environment, have been used in many commercial applications since the 1940s. Of late, the detection of PFAS in drinking water throughout the United States has raised public and scientific concerns. To understand PFAS exposure trends in the general U.S. population, we analyzed select PFAS serum concentration data from participants ≥12 years old of nine National Health and Nutrition Examination Survey (NHANES) cycles. Our goals were to a) evaluate concentration changes of four legacy PFAS-perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) from 1999 to 2000 to 2017-March 2020, b) discuss serum concentrations and assess demographic predictors of two PFAS measured for the first time in 2017-2018, perfluoro-1-heptanesulfonic acid (PFHpS) and 9-chlorohexadecafluoro-3-oxanonane-1-sulfonic acid (9CLPF), and c) compare concentration profiles of legacy PFAS in NHANES to profiles in exposed communities. We report a decrease in geometric mean concentrations of the four legacy PFAS (16%-87%, depending on the PFAS) from 1999 to 2000, although in 2017-March 2020, more than 96% of people aged 12-19 years, some of whom were born after PFAS production changes started in the early 2000s, had measurable concentrations of these PFAS. An estimated 78% of the U.S. general population had detectable concentrations of PFHpS, and 8% had detectable concentrations of 9CLPF (>44% of whom self-identified as Asian). Comparing profiles in NHANES and people living in communities with PFAS contamination can help identify exposure sources and evaluate and monitor exposures in select areas or among specific population groups. Collectively, our findings highlight the usefulness of NHANES data to help researchers, public health officials, and policy makers prioritize investigations, monitor exposure changes, and evaluate effectiveness of efforts to limit exposures. AB - Author manuscript AN - cdc:261744 C4 - PMC12082571 DO - https://doi.org/10.1016/j.envres.2025.120916 J2 - Environmental Research KW - Adolescent KW - Female KW - Nutrition Surveys KW - Aged KW - Young Adult KW - Child KW - Fluorocarbons KW - Alkanesulfonic Acids KW - Environmental Pollutants KW - Male KW - Humans KW - Middle Aged KW - Environmental Monitoring KW - Environmental Exposure KW - Caprylates KW - Adult KW - Biomonitoring KW - NHANES KW - Serum KW - PFAS KW - PFOA KW - PFOS KW - PFHxS KW - PFNA KW - PFHpS KW - 9CLPF KW - Fluorocarbons KW - Humans KW - Nutrition Surveys KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Male KW - Female KW - Young Adult KW - Adolescent KW - Environmental Pollutants KW - Alkanesulfonic Acids KW - Caprylates KW - Environmental Monitoring KW - Aged KW - Child LA - eng PY - 2025 T2 - Environmental Research T2 - Environmental Research, 2025, v. 270 TI - Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020. VL - 270 UR - https://stacks.cdc.gov/view/cdc/261744 ER -
Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study.

Waltzman, Dana ;

Miller, Gabrielle F.

November 24, 2025 | The Journal of Head Trauma Rehabilitation, 2025, v. 40, no. 4

Traumatic brain injury (TBI) can result in new onset of comorbidities and limited studies suggest health care utilization following TBI may be high. Setting, Participants, Mean Measures, and Design: This study used 2018 and 2019 MarketScan Commercial Claims and Encounters data to examine differences in longitudinal health outcomes (health care util ...

10/09/2026

Supporting Files

Title : Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study. Personal Author(s) : Waltzman, Dana;Miller, Gabrielle F.;Xu, Likang;Haarbauer-Krupa, Juliet;Hammond, Flora M.; Published Date : November 24, 2025 Pages in Document : 233-246 (20 pdf pages) Source : The Journal of Head Trauma Rehabilitation, 2025, v. 40, no. 4 DOI : https://doi.org/10.1097/HTR.0000000000001008 Journal Title : The Journal of Head Trauma Rehabilitation
Waltzman, D., Miller, G. F., Xu, L., Haarbauer-Krupa, J., & Hammond, F. M. (2025). Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study. The Journal of Head Trauma Rehabilitation, 40(4). https://doi.org/10.1097/HTR.0000000000001008

Waltzman, Dana, Gabrielle F. Miller, Likang Xu, Juliet Haarbauer-Krupa, and Flora M. Hammond. "Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study." The Journal of Head Trauma Rehabilitation 40, no. 4 (2025). https://doi.org/10.1097/HTR.0000000000001008.

Waltzman, Dana, et al. "Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study." The Journal of Head Trauma Rehabilitation, vol. 40, no. 4, 2025. Stacks. https://doi.org/10.1097/HTR.0000000000001008.
Export RIS Citation Information. TY - Journal Article AU - Waltzman, Dana AU - Miller, Gabrielle F. AU - Xu, Likang AU - Haarbauer-Krupa, Juliet AU - Hammond, Flora M. AB - Traumatic brain injury (TBI) can result in new onset of comorbidities and limited studies suggest health care utilization following TBI may be high. Setting, Participants, Mean Measures, and Design: This study used 2018 and 2019 MarketScan Commercial Claims and Encounters data to examine differences in longitudinal health outcomes (health care utilization and new diagnoses) by various demographic factors (age, sex, U.S. region, intent/mechanism of injury, urbanicity, and insurance status) among individuals with and without a TBI in the year following an index health care encounter. AB - Results show that within 1 year of the initial encounter, a higher percentage of patients with TBI versus without TBI had at least one outpatient visit (96.7% vs 86.1%), emergency department (ED) visit (28.5% vs 13.1%), or hospital admission (6.4% vs 2.6%). Both children (33.8% vs 23.4%) and adults (43.8% vs 31.4%) who sustained a TBI had a higher percentage of new diagnoses within 1 year compared to the non-TBI group. Additionally, individuals with a TBI had greater health care utilization across all types of health care settings (outpatient and inpatient), visits (ED visits and hospital admissions), and across all demographic factors ( P < .001). AB - These results may inform future research around the development of systems of care to improve longer-term outcomes in individuals with TBI. AB - Author manuscript AN - cdc:261743 C4 - PMC12237604 DO - https://doi.org/10.1097/HTR.0000000000001008 IS - 4 J2 - The Journal of Head Trauma Rehabilitation KW - Longitudinal Studies KW - Adolescent KW - Female KW - Aged KW - Young Adult KW - Emergency Service, Hospital KW - Patient Acceptance of Health Care KW - Child KW - Infant KW - Hospitalization KW - Male KW - Middle Aged KW - Humans KW - Child, Preschool KW - Adult KW - Brain Injuries, Traumatic KW - health care utilization KW - longitudinal KW - traumatic brain injury KW - Humans KW - Brain Injuries, Traumatic KW - Male KW - Female KW - Longitudinal Studies KW - Adult KW - Middle Aged KW - Patient Acceptance of Health Care KW - Adolescent KW - Child KW - Young Adult KW - Aged KW - Child, Preschool KW - Emergency Service, Hospital KW - Infant KW - Hospitalization LA - eng PY - 2025 T2 - The Journal of Head Trauma Rehabilitation T2 - The Journal of Head Trauma Rehabilitation, 2025, v. 40, no. 4 TI - Health and Health Care Utilization Outcomes For Individuals With Traumatic Brain Injury: a 1-Year Longitudinal Study. VL - 40 UR - https://stacks.cdc.gov/view/cdc/261743 ER -
Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa.

Scheibe, Andrew ;

Steingo, Joel

March 2025 | The International Journal on Drug Policy, 2025, v. 137

Hepatitis B virus (HBV) and hepatitis C virus (HCV) are estimated to be of the most prevalent infectious diseases in correctional settings worldwide. However, viral hepatitis services have not been routinely integrated into South African correctional facilities. We aimed to assess prevalence of HBV infection and HCV infection among people accessing ...

10/09/2026

Supporting Files

Title : Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa. Personal Author(s) : Scheibe, Andrew;Steingo, Joel;Grace, Gaynor;Savva, Helen;Sonderup, Mark;Hausler, Harry;Spearman, C. Wendy; Published Date : March 2025 Pages in Document : 104710 (16 pdf pages) Source : The International Journal on Drug Policy, 2025, v. 137 DOI : https://doi.org/10.1016/j.drugpo.2025.104710 Journal Title : The International Journal on Drug Policy
Scheibe, A., Steingo, J., Grace, G., Savva, H., Sonderup, M., Hausler, H., & Spearman, C. W. (2025). Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa. The International Journal on Drug Policy, 137. https://doi.org/10.1016/j.drugpo.2025.104710

Scheibe, Andrew, Joel Steingo, Gaynor Grace, Helen Savva, Mark Sonderup, Harry Hausler, and C. Wendy Spearman. "Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa." The International Journal on Drug Policy 137 (2025). https://doi.org/10.1016/j.drugpo.2025.104710.

Scheibe, Andrew, et al. "Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa." The International Journal on Drug Policy, vol. 137, 2025. Stacks. https://doi.org/10.1016/j.drugpo.2025.104710.
Export RIS Citation Information. TY - Journal Article AU - Scheibe, Andrew AU - Steingo, Joel AU - Grace, Gaynor AU - Savva, Helen AU - Sonderup, Mark AU - Hausler, Harry AU - Spearman, C. Wendy AB - Hepatitis B virus (HBV) and hepatitis C virus (HCV) are estimated to be of the most prevalent infectious diseases in correctional settings worldwide. However, viral hepatitis services have not been routinely integrated into South African correctional facilities. We aimed to assess prevalence of HBV infection and HCV infection among people accessing HIV services and assess the feasibility of viral hepatitis service integration in a South African correctional centre. AB - Voluntarily participating people in a correctional services facility were offered free hepatitis B surface antigen (HBsAg) and anti-HCV point-of-care testing in addition to routine HIV testing and treatment services on a first-come, first-served basis during June 2021-March 2022. Off-site laboratory testing (HBV and HCV molecular testing and non-invasive liver fibrosis staging) and screening for hepatocellular carcinoma informed further management. A general practitioner at the facility managed participants, with virtual support from hepatologists. Data on age and history of injecting was collected and point-of-care and laboratory results were recorded. Data were analysed using descriptive statistics. AB - The median age of the 765 people who participated was 32.5 years (IQR 27.5 - 38.2), with 2.2% (17/765) reporting having ever injected a drug. The sample prevalence was 3.9% (30/765) for HBV infection, 0.5% (3/665) for HCV infection, and 1.2% (9/765) for HIV-HBV coinfection. Thirty people had reactive HBsAg point-of-care tests. Among those with reactive HBsAg point-of-care tests 90.0% (27/30) received work-up, among whom 48.1% (13/27) were monitored, 44.4% (12/27) were placed on treatment and two people were released before a management plan could be finalised. Of those treated 33.3% (4/12) started tenofovir/emtricitabine and 66.7% (8/12) antiretroviral therapy. Of the eligible participants, 27.3% (201/735) received at least one hepatitis B vaccine dose and 26.9% (54/201) received three doses. All three participants who had confirmed HCV infection were started on direct-acting antivirals. Of the two completing treatment one achieved sustained virological response at 12 weeks (SVR12), one person was released before SVR12 was done. One person was lost to follow-up. No clinical adverse events were reported. AB - There was a notable viral hepatitis burden among people in this correctional centre and integration of viral hepatitis services into the existing HIV services was acceptable and feasible. Further efforts to sustain and expand access to viral hepatitis services in South African correctional centres could catalyse national viral hepatitis elimination efforts. AB - Author manuscript AN - cdc:261742 C4 - PMC11892007 DO - https://doi.org/10.1016/j.drugpo.2025.104710 J2 - The International Journal on Drug Policy KW - Female KW - Mass Screening KW - Feasibility Studies KW - Young Adult KW - Prisons KW - Point-of-Care Testing KW - Coinfection KW - Hepatitis B KW - Hepatitis C KW - Prevalence KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Substance Abuse, Intravenous KW - Correctional Facilities KW - HIV Infections KW - Prison KW - Corrections KW - HCV KW - HIV KW - Linkage to care KW - Humans KW - Male KW - Adult KW - Female KW - HIV Infections KW - Feasibility Studies KW - Hepatitis B KW - Hepatitis C KW - Prevalence KW - Middle Aged KW - Point-of-Care Testing KW - Correctional Facilities KW - Substance Abuse, Intravenous KW - Young Adult KW - Prisons KW - Coinfection KW - Mass Screening LA - eng PY - 2025 T2 - The International Journal on Drug Policy T2 - The International Journal on Drug Policy, 2025, v. 137 TI - Feasibility of Implementing Viral Hepatitis Services Into a Correctional Service Facility in Cape Town, South Africa. VL - 137 UR - https://stacks.cdc.gov/view/cdc/261742 ER -
Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey.

Jang, Dae-Gyu ;

Federico, Antonio

March 2025 | Journal of the Neurological Sciences, 2025, v. 470

Rare neurologic diseases (RNDs) are difficult to diagnose and treat due to their low prevalence and complex nature. This survey evaluated awareness and current care status of RNDs among esteemed neurologists affiliated with the World Federation of Neurology (WFN).A 34-question survey was distributed to renowned neurologists, including delegates fro ...

10/09/2026

Supporting Files

Title : Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey. Personal Author(s) : Jang, Dae-Gyu;Federico, Antonio;Savelieff, Masha G.;Grisold, Wolfgang;Mancuso, Michelangelo;Molnar, Maria J.;Feldman, Eva L.;Reynolds, Evan L.; Published Date : March 2025 Pages in Document : 123395 (19 pdf pages) Source : Journal of the Neurological Sciences, 2025, v. 470 DOI : https://doi.org/10.1016/j.jns.2025.123395 Journal Title : Journal of the Neurological Sciences
Jang, D. G., Federico, A., Savelieff, M. G., Grisold, W., Mancuso, M., Molnar, M. J., Feldman, E. L., & Reynolds, E. L. (2025). Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey. Journal of the Neurological Sciences, 470. https://doi.org/10.1016/j.jns.2025.123395

Jang, Dae-Gyu, Antonio Federico, Masha G. Savelieff, Wolfgang Grisold, Michelangelo Mancuso, Maria J. Molnar, Eva L. Feldman, and Evan L. Reynolds. "Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey." Journal of the Neurological Sciences 470 (2025). https://doi.org/10.1016/j.jns.2025.123395.

Jang, Dae-Gyu, et al. "Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey." Journal of the Neurological Sciences, vol. 470, 2025. Stacks. https://doi.org/10.1016/j.jns.2025.123395.
Export RIS Citation Information. TY - Journal Article AU - Jang, Dae-Gyu AU - Federico, Antonio AU - Savelieff, Masha G. AU - Grisold, Wolfgang AU - Mancuso, Michelangelo AU - Molnar, Maria J. AU - Feldman, Eva L. AU - Reynolds, Evan L. AB - Rare neurologic diseases (RNDs) are difficult to diagnose and treat due to their low prevalence and complex nature. This survey evaluated awareness and current care status of RNDs among esteemed neurologists affiliated with the World Federation of Neurology (WFN). AB - A 34-question survey was distributed to renowned neurologists, including delegates from national neurology societies in the WFN Assembly, various WFN committees, and members of the Rare Neurologic Diseases Specialist group. Responses were stratified by geographical regions, including Africa, the Americas, Asia/Oceania, and Europe, and into four income groups based on the World Bank Indicator. Descriptive statistics summarized responses, stratified by geographical regions or income groups, and significant differences were assessed by Fisher's exact test. AB - Of 190 invited neurologists, 64 responded (34 % response rate). Among respondents, 89 % agreed that RND patients should receive timely and effective care on par with more common neurological conditions. Additionally, 77 % of respondents overall thought most RNDs could be accurately diagnosed in their country. However, there were significant differences in the perceived ability of respondents' country of practice to diagnose RNDs by region, specifically in Africa (25 %), and by income of country of practice, specifically in the lower-income group (17 %). AB - This global survey highlights varying RND diagnosis and care by country socioeconomic status, suggesting potential disparities in resources and preparedness. To improve outcomes and quality-of-life for RND patients, efforts should focus on improving diagnostic capabilities, fostering collaboration among neurology centers, and promoting education on the unique challenges and treatment options of RNDs. AB - Author manuscript AN - cdc:261741 C4 - PMC11846688 DO - https://doi.org/10.1016/j.jns.2025.123395 J2 - Journal of the Neurological Sciences KW - Health Knowledge, Attitudes, Practice KW - Surveys and Questionnaires KW - Female KW - Global Health KW - Neurologists KW - Neurology KW - Male KW - Nervous System Diseases KW - Humans KW - Awareness KW - Rare Diseases KW - attitudes KW - awareness KW - diagnosis KW - care KW - knowledge KW - practice KW - Humans KW - Neurologists KW - Nervous System Diseases KW - Surveys and Questionnaires KW - Rare Diseases KW - Health Knowledge, Attitudes, Practice KW - Global Health KW - Male KW - Female KW - Neurology KW - Awareness LA - eng PY - 2025 T2 - Journal of the Neurological Sciences T2 - Journal of the Neurological Sciences, 2025, v. 470 TI - Awareness and Care Practices For Rare Neurologic Diseases Among Senior Neurologists: a Global Survey. VL - 470 UR - https://stacks.cdc.gov/view/cdc/261741 ER -
Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress.

Hess, Hayden W. ;

Heikkinen, Molly E.

March 2025 | Journal of Applied Physiology (Bethesda, Md. : 1985), 2025, v. 138, no. 3

Violation of the National Institute of Occupational Safety and Health (NIOSH) heat stress recommendations by exceeding the allowable wet bulb globe temperature (WBGT) for a given work intensity and work-rest ratio augments acute kidney injury (AKI) risk. Here, we tested the hypothesis that exceeding the allowable work intensity at a given WBGT and ...

10/09/2026

Supporting Files

Title : Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress. Personal Author(s) : Hess, Hayden W.;Heikkinen, Molly E.;Tourula, Erica;Hite, M. Jo;Rivers, Kelli;Zoh, Roger S.;Johnson, Blair D.;Hostler, David;Schlader, Zachary J.; Published Date : March 2025 Pages in Document : 706-717 (26 pdf pages) Source : Journal of Applied Physiology (Bethesda, Md. : 1985), 2025, v. 138, no. 3 DOI : https://doi.org/10.1152/japplphysiol.00590.2024 Journal Title : Journal of Applied Physiology (Bethesda, Md. : 1985)
Hess, H. W., Heikkinen, M. E., Tourula, E., Hite, M. J., Rivers, K., Zoh, R. S., Johnson, B. D., Hostler, D., & Schlader, Z. J. (2025). Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress. Journal of Applied Physiology (Bethesda, Md. : 1985), 138(3). https://doi.org/10.1152/japplphysiol.00590.2024

Hess, Hayden W., Molly E. Heikkinen, Erica Tourula, M. Jo Hite, Kelli Rivers, Roger S. Zoh, Blair D. Johnson, David Hostler, and Zachary J. Schlader. "Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress." Journal of Applied Physiology (Bethesda, Md. : 1985) 138, no. 3 (2025). https://doi.org/10.1152/japplphysiol.00590.2024.

Hess, Hayden W., et al. "Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 138, no. 3, 2025. Stacks. https://doi.org/10.1152/japplphysiol.00590.2024.
Export RIS Citation Information. TY - Journal Article AU - Hess, Hayden W. AU - Heikkinen, Molly E. AU - Tourula, Erica AU - Hite, M. Jo AU - Rivers, Kelli AU - Zoh, Roger S. AU - Johnson, Blair D. AU - Hostler, David AU - Schlader, Zachary J. AB - Violation of the National Institute of Occupational Safety and Health (NIOSH) heat stress recommendations by exceeding the allowable wet bulb globe temperature (WBGT) for a given work intensity and work-rest ratio augments acute kidney injury (AKI) risk. Here, we tested the hypothesis that exceeding the allowable work intensity at a given WBGT and work-rest ratio would also worsen AKI risk. Twelve healthy adults completed two NIOSH recommendation compliant trials and one noncompliant trial consisting of a 4 h (half workday) exposure. Work-rest ratio was fixed at 30 min of walking and 30 min of rest each hour. Work intensity (metabolic heat production) was prescribed as a function of WBGT-412 ± 51 W [27.3 ± 0.3°C; high-intensity compliant (C AB - )], 290 ± 75 W [31.6 ± 0.2°C; low-intensity compliant (C AB - )], and 410 ± 61 W [31.7 ± 0.2°C; high-intensity noncompliant (NC AB - )]. AKI risk was quantified by the product of urinary insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 normalized to urine specific gravity ([IGFBP7·TIMP-2] AB - ). Peak core temperature was higher in NC AB - trial (38.3 ± 0.4°C) compared with the compliant trials (C AB - : 38.0 ± 0.3°C; C AB - : 37.8 ± 0.4°C; AB - ≤ 0.0095). [IGFBP7·TIMP-2] AB - increased from pre- to immediately postexposure in all trials (time effect: AB - = 0.0454) but the peak increase was not different between trials [C AB - : 0.89 ± 1.7 (ng/mL) AB - /1,000; C AB - : 0.78 ± 1.7 (ng/mL) AB - /1,000; NC AB - : 1.0 ± 1.4 (ng/mL) AB - /1,000; AB - = 0.7811]. Violating the NIOSH recommendations by exceeding either the allowable work intensity (i.e., NC AB - vs. C AB - ) or WBGT (i.e., NC AB - vs. C AB - ) resulted in a modest elevation in peak core temperature but did not modify AKI risk. AB - We demonstrate that violation of the National Institute for Occupational Safety and Health heat stress recommendations by exceeding allowable work intensity by ∼120 W or environmental limits by ∼4°C wet bulb globe temperature (WBGT) at 30-min work-rest per hour results in a modest elevation in peak core temperature but does not augment acute kidney injury risk compared with scenarios that adhered to the NIOSH recommendations during simulated occupational heat stress. AB - Author manuscript AN - cdc:261740 C4 - PMC12199259 DO - https://doi.org/10.1152/japplphysiol.00590.2024 IS - 3 J2 - Journal of Applied Physiology (Bethesda, Md. : 1985) KW - Occupational Exposure KW - Body Temperature KW - Female KW - Heat Stress Disorders KW - Physical Exertion KW - Tissue Inhibitor of Metalloproteinase-2 KW - Young Adult KW - Occupational Diseases KW - Heat-Shock Response KW - Hot Temperature KW - Acute Kidney Injury KW - Risk Factors KW - Male KW - Humans KW - Insulin-Like Growth Factor Binding Proteins KW - Adult KW - acute kidney injury KW - kidney function KW - heat stress KW - hydration KW - Humans KW - Acute Kidney Injury KW - Male KW - Adult KW - Heat Stress Disorders KW - Female KW - Hot Temperature KW - Tissue Inhibitor of Metalloproteinase-2 KW - Insulin-Like Growth Factor Binding Proteins KW - Young Adult KW - Occupational Exposure KW - Physical Exertion KW - Body Temperature KW - Heat-Shock Response KW - Occupational Diseases KW - Risk Factors LA - eng PY - 2025 T2 - Journal of Applied Physiology (Bethesda, Md. : 1985) T2 - Journal of Applied Physiology (Bethesda, Md. : 1985), 2025, v. 138, no. 3 TI - Influence of Work Intensity on Acute Kidney Injury Risk During Simulated Occupational Heat Stress. VL - 138 UR - https://stacks.cdc.gov/view/cdc/261740 ER -
Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination.

Khetsuriani, Nino ;

Tursunova, Dilorom

February 2025 | Vaccine, 2025, v. 48

Uzbekistan, a highly endemic country for hepatitis B virus (HBV), introduced infant vaccination with hepatitis B vaccine (HepB) in 2001. Since 2002, it had ≥90 % reported immunization coverage for ≥3 doses of HepB (HepB3) and the birth dose (HepB-BD). However, the impact of HepB vaccination and the progress towards achieving the regional hepatitis ...

10/09/2026

Supporting Files

Title : Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination. Personal Author(s) : Khetsuriani, Nino;Tursunova, Dilorom;Kasimova, Rano;Sharapov, Saidkhon;Stewart, Brock;Matyakubov, Mansurbek;Latipov, Renat;Mosina, Liudmila;Yusupaliyev, Bakhodir;Musabaev, Erkin; Published Date : February 2025 Pages in Document : 126743 (19 pdf pages) Source : Vaccine, 2025, v. 48 DOI : https://doi.org/10.1016/j.vaccine.2025.126743 Journal Title : Vaccine
Khetsuriani, N., Tursunova, D., Kasimova, R., Sharapov, S., Stewart, B., Matyakubov, M., Latipov, R., Mosina, L., Yusupaliyev, B., & Musabaev, E. (2025). Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination. Vaccine, 48. https://doi.org/10.1016/j.vaccine.2025.126743

Khetsuriani, Nino, Dilorom Tursunova, Rano Kasimova, Saidkhon Sharapov, Brock Stewart, Mansurbek Matyakubov, Renat Latipov, Liudmila Mosina, Bakhodir Yusupaliyev, and Erkin Musabaev. "Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination." Vaccine 48 (2025). https://doi.org/10.1016/j.vaccine.2025.126743.

Khetsuriani, Nino, et al. "Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination." Vaccine, vol. 48, 2025. Stacks. https://doi.org/10.1016/j.vaccine.2025.126743.
Export RIS Citation Information. TY - Journal Article AU - Khetsuriani, Nino AU - Tursunova, Dilorom AU - Kasimova, Rano AU - Sharapov, Saidkhon AU - Stewart, Brock AU - Matyakubov, Mansurbek AU - Latipov, Renat AU - Mosina, Liudmila AU - Yusupaliyev, Bakhodir AU - Musabaev, Erkin AB - Uzbekistan, a highly endemic country for hepatitis B virus (HBV), introduced infant vaccination with hepatitis B vaccine (HepB) in 2001. Since 2002, it had ≥90 % reported immunization coverage for ≥3 doses of HepB (HepB3) and the birth dose (HepB-BD). However, the impact of HepB vaccination and the progress towards achieving the regional hepatitis B control and global viral hepatitis B elimination goals had not been assessed. AB - To determine current HBsAg prevalence among children in Uzbekistan, in 2022, we conducted a nationwide serosurvey among schoolchildren (grades 1-3) using a stratified, multi-stage cluster design. Participants' basic demographics and HepB immunization information were obtained. Blood specimens were tested for HBsAg using a WHO-prequalified rapid test (Bioline HBsAg WB, Abbott Diagnostics). Samples with positive and indeterminate results were tested for HBsAg by ELISA (Murex HBsAg Version3, Diasorine). Weighted proportions and adjusted 95 % confidence intervals (CI) were calculated. AB - Of 4119 children enrolled in 148 schools, blood was collected from 3753 (91.1 %) and immunization data were available for 3833 (93.3 %). National HBsAg prevalence was 0.20 % (adjusted 95 % CI, 0.09 %-0.38 %). Among children with available immunization data, 97.7 % (97.2 %-98.1 %) received ≥3 HepB doses and 94.9 % (94.1 %-95.5 %) received HepB-BD, including timely HepB-BD in 93.7 % (92.9 %-94.5 %). AB - The survey demonstrated that Uzbekistan has met the <0.5 % European regional HBsAg seroprevalence target and has made substantial progress towards meeting the <0.1 % HBsAg seroprevalence target for the elimination of HBV mother to-child transmission (MTCT). Based on these findings and ≥ 90 % HepB-BD and HepB3 coverage, in 2023, Uzbekistan was validated as having achieved the regional hepatitis B control goal. To achieve the elimination of MTCT of HBV, additional interventions, including improving antenatal screening for HBsAg, providing antiviral treatment of eligible HBsAg-positive pregnant women and hepatitis B immunoglobulin to infants born to HBsAg-positive mothers, should be considered. AB - Author manuscript AN - cdc:261739 C4 - PMC12875403 DO - https://doi.org/10.1016/j.vaccine.2025.126743 J2 - Vaccine KW - Seroepidemiologic Studies KW - Adolescent KW - Child KW - Hepatitis B, Chronic KW - Female KW - Vaccination KW - Hepatitis B Surface Antigens KW - Prevalence KW - Male KW - Humans KW - Hepatitis B virus KW - Hepatitis B Vaccines KW - Hepatitis B KW - Serosurvey KW - Uzbekistan KW - HBsAg prevalence KW - Viral hepatitis KW - Viral hepatitis elimination KW - Hepatitis B vaccination KW - Humans KW - Female KW - Male KW - Hepatitis B Vaccines KW - Child KW - Prevalence KW - Hepatitis B Surface Antigens KW - Hepatitis B, Chronic KW - Seroepidemiologic Studies KW - Vaccination KW - Adolescent KW - Hepatitis B virus LA - eng PY - 2025 T2 - Vaccine T2 - Vaccine, 2025, v. 48 TI - Prevalence of Chronic Hepatitis B Virus Infection Among Children in Uzbekistan: Impact of Vaccination. VL - 48 UR - https://stacks.cdc.gov/view/cdc/261739 ER -
The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs.

Li, Yin ;

Aiken, Linda H.

March 1, 2026 | Nursing Outlook, 2026, v. 73, no. 2

Sepsis is a common cause of hospitalization among Medicare beneficiaries, often leading to prolonged hospital stays and high costs.To estimate the impact of registered nurse (RN) staffing and skill mix on hospital lengths of stay and associated costs for Medicare beneficiaries with sepsis.A retrospective, cross-sectional analysis was conducted usin ...

10/09/2026

Supporting Files

Title : The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs. Personal Author(s) : Li, Yin;Aiken, Linda H.;Becker, Edmund R.;Razmpour, Omid;Landerfelt, Patti;Kang, Yu Jin;Cimiotti, Jeannie P.; Published Date : March 1, 2026 Pages in Document : 102356 (14 pdf pages) Source : Nursing Outlook, 2026, v. 73, no. 2 DOI : https://doi.org/10.1016/j.outlook.2025.102356 Journal Title : Nursing Outlook
Li, Y., Aiken, L. H., Becker, E. R., Razmpour, O., Landerfelt, P., Kang, Y. J., & Cimiotti, J. P. (2026). The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs. Nursing Outlook, 73(2). https://doi.org/10.1016/j.outlook.2025.102356

Li, Yin, Linda H. Aiken, Edmund R. Becker, Omid Razmpour, Patti Landerfelt, Yu Jin Kang, and Jeannie P. Cimiotti. "The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs." Nursing Outlook 73, no. 2 (2026). https://doi.org/10.1016/j.outlook.2025.102356.

Li, Yin, et al. "The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs." Nursing Outlook, vol. 73, no. 2, 2026. Stacks. https://doi.org/10.1016/j.outlook.2025.102356.
Export RIS Citation Information. TY - Journal Article AU - Li, Yin AU - Aiken, Linda H. AU - Becker, Edmund R. AU - Razmpour, Omid AU - Landerfelt, Patti AU - Kang, Yu Jin AU - Cimiotti, Jeannie P. AB - Sepsis is a common cause of hospitalization among Medicare beneficiaries, often leading to prolonged hospital stays and high costs. AB - To estimate the impact of registered nurse (RN) staffing and skill mix on hospital lengths of stay and associated costs for Medicare beneficiaries with sepsis. AB - A retrospective, cross-sectional analysis was conducted using 2018 data from 2,107 acute care hospitals, including 653,496 patients with sepsis. AB - A one-unit increase in RN hours per patient day and a 1% increase in RN skill mix reduced hospital stays by 2% and 1%, respectively. Enhancing staffing to nine RN hours per patient day and an 80% RN skill mix could save 63,580 inpatient days annually, reducing costs by $152.9 million. Further increases to 11 RN hours and an 85% skill mix could save $331.9 million. AB - Better RN staffing and skill mix can improve patient outcomes and yield significant cost savings. AB - Author manuscript AN - cdc:261738 C4 - PMC12058405 DO - https://doi.org/10.1016/j.outlook.2025.102356 IS - 2 J2 - Nursing Outlook KW - Medicare KW - Female KW - Aged KW - Hospital Costs KW - Retrospective Studies KW - Aged, 80 and over KW - Cross-Sectional Studies KW - Nursing Staff, Hospital KW - Male KW - Length of Stay KW - Personnel Staffing and Scheduling KW - Humans KW - Clinical Competence KW - Health care costs KW - Nursing KW - Acute Inpatient Care KW - hospitals KW - Medicare KW - Humans KW - Cross-Sectional Studies KW - Retrospective Studies KW - Length of Stay KW - Personnel Staffing and Scheduling KW - Female KW - Hospital Costs KW - Male KW - Nursing Staff, Hospital KW - Aged KW - Medicare KW - Aged, 80 and over KW - Clinical Competence LA - eng PY - 2026 T2 - Nursing Outlook T2 - Nursing Outlook, 2026, v. 73, no. 2 TI - The Effect of Registered Nurse Staffing and Skill Mix on Length of Stay and Hospital Costs. VL - 73 UR - https://stacks.cdc.gov/view/cdc/261738 ER -
Estimating the Generation Time For Influenza Transmission Using Household Data in the United States.

Chan, Louis Yat Hin ;

Morris, Sinead E.

March 2025 | Epidemics, 2025, v. 50

The generation time, representing the interval between infections in primary and secondary cases, is essential for understanding and predicting the transmission dynamics of seasonal influenza, including the real-time effective reproduction number (Rt). However, comprehensive generation time estimates for seasonal influenza, especially since the 200 ...

10/09/2026

Supporting Files

Title : Estimating the Generation Time For Influenza Transmission Using Household Data in the United States. Personal Author(s) : Chan, Louis Yat Hin;Morris, Sinead E.;Stockwell, Melissa S.;Bowman, Natalie M.;Asturias, Edwin;Rao, Suchitra;Lutrick, Karen;Ellingson, Katherine D.;Nguyen, Huong Q.;Maldonado, Yvonne;McLaren, Son H.;Sano, Ellen;Biddle, Jessica E.;Smith-Jeffcoat, Sarah E.;Biggerstaff, Matthew;Rolfes, Melissa A.;Talbot, H. Keipp;Grijalva, Carlos G.;Borchering, Rebecca K.;Mellis, Alexandra M.; Corporate Authors(s) : RVTN-Sentinel Study Group Published Date : March 2025 Pages in Document : 100815 (18 pdf pages) Source : Epidemics, 2025, v. 50 DOI : https://doi.org/10.1016/j.epidem.2025.100815 Journal Title : Epidemics
Chan, L. Y. H., Morris, S. E., Stockwell, M. S., Bowman, N. M., Asturias, E., Rao, S., Lutrick, K., Ellingson, K. D., Nguyen, H. Q., Maldonado, Y., McLaren, S. H., Sano, E., Biddle, J. E., Smith-Jeffcoat, S. E., Biggerstaff, M., Rolfes, M. A., Talbot, H. K., Grijalva, C. G., Borchering, R. K., & Mellis, A. M. (2025). Estimating the Generation Time For Influenza Transmission Using Household Data in the United States. Epidemics, 50. https://doi.org/10.1016/j.epidem.2025.100815

Chan, Louis Yat Hin, Sinead E. Morris, Melissa S. Stockwell, Natalie M. Bowman, Edwin Asturias, Suchitra Rao, and Karen Lutrick, et al.. "Estimating the Generation Time For Influenza Transmission Using Household Data in the United States." Epidemics 50 (2025). https://doi.org/10.1016/j.epidem.2025.100815.

Chan, Louis Yat Hin, et al. "Estimating the Generation Time For Influenza Transmission Using Household Data in the United States." Epidemics, vol. 50, 2025. Stacks. https://doi.org/10.1016/j.epidem.2025.100815.
Export RIS Citation Information. TY - Journal Article AU - Chan, Louis Yat Hin AU - Morris, Sinead E. AU - Stockwell, Melissa S. AU - Bowman, Natalie M. AU - Asturias, Edwin AU - Rao, Suchitra AU - Lutrick, Karen AU - Ellingson, Katherine D. AU - Nguyen, Huong Q. AU - Maldonado, Yvonne AU - McLaren, Son H. AU - Sano, Ellen AU - Biddle, Jessica E. AU - Smith-Jeffcoat, Sarah E. AU - Biggerstaff, Matthew AU - Rolfes, Melissa A. AU - Talbot, H. Keipp AU - Grijalva, Carlos G. AU - Borchering, Rebecca K. AU - Mellis, Alexandra M. A2 - RVTN-Sentinel Study Group AB - The generation time, representing the interval between infections in primary and secondary cases, is essential for understanding and predicting the transmission dynamics of seasonal influenza, including the real-time effective reproduction number (Rt). However, comprehensive generation time estimates for seasonal influenza, especially since the 2009 influenza pandemic, are lacking. We estimated the generation time utilizing data from a 7-site case-ascertained household study in the United States over two influenza seasons, 2021/2022 and 2022/2023. More than 200 individuals who tested positive for influenza and their household contacts were enrolled within 7 days of the first illness in the household. All participants were prospectively followed for 10 days, completing daily symptom diaries and collecting nasal swabs, which were then tested for influenza via RT-PCR. We analyzed these data by modifying a previously published Bayesian data augmentation approach that imputes infection times of cases to obtain both intrinsic (assuming no susceptible depletion) and realized (observed within household) generation times. We assessed the robustness of the generation time estimate by varying the incubation period, and generated estimates of the proportion of transmission occurring before symptomatic onset, the infectious period, and the latent period. We estimated a mean intrinsic generation time of 3.2 (95 % credible interval, CrI: 2.9-3.6) days, with a realized household generation time of 2.8 (95 % CrI: 2.7-3.0) days. The generation time exhibited limited sensitivity to incubation period variation. Estimates of the proportion of transmission that occurred before symptom onset, the infectious period, and the latent period were sensitive to variations in the incubation period. Our study contributes to the ongoing efforts to refine estimates of the generation time for influenza. Our estimates, derived from recent data following the COVID-19 pandemic, are consistent with previous pre-pandemic estimates, and will be incorporated into real-time Rt estimation efforts. AB - Author manuscript AN - cdc:261737 C4 - PMC11986874 DO - https://doi.org/10.1016/j.epidem.2025.100815 J2 - Epidemics KW - Adolescent KW - Female KW - Bayes Theorem KW - Family Characteristics KW - Prospective Studies KW - Young Adult KW - Child KW - Seasons KW - Male KW - Middle Aged KW - Humans KW - Child, Preschool KW - Time Factors KW - Adult KW - Influenza, Human KW - Basic Reproduction Number KW - Generation interval KW - Serial interval KW - Incubation period KW - Pre-symptomatic transmission KW - Household transmission KW - Respiratory diseases KW - Humans KW - Influenza, Human KW - Family Characteristics KW - Female KW - Adult KW - Male KW - Bayes Theorem KW - Time Factors KW - Middle Aged KW - Seasons KW - Child KW - Young Adult KW - Adolescent KW - Basic Reproduction Number KW - Child, Preschool KW - Prospective Studies LA - eng PY - 2025 T2 - Epidemics T2 - Epidemics, 2025, v. 50 TI - Estimating the Generation Time For Influenza Transmission Using Household Data in the United States. VL - 50 UR - https://stacks.cdc.gov/view/cdc/261737 ER -
Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States.

Gold, Jeremy A. W. ;

Benedict, Kaitlin

May 2025 | Journal of the American Academy of Dermatology, 2025, v. 92, no. 5

Letter to the editor to discuss diagnosing superficial dermatomycoses tinea nigra, white piedra, and black piedra.

10/09/2026

Supporting Files

Title : Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States. Personal Author(s) : Gold, Jeremy A. W.;Benedict, Kaitlin;Lipner, Shari R.; Published Date : May 2025 Pages in Document : 1148-1151 (6 pdf pages) Source : Journal of the American Academy of Dermatology, 2025, v. 92, no. 5 DOI : https://doi.org/10.1016/j.jaad.2025.01.053 Journal Title : Journal of the American Academy of Dermatology
Gold, J. A. W., Benedict, K., & Lipner, S. R. (2025). Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States. Journal of the American Academy of Dermatology, 92(5). https://doi.org/10.1016/j.jaad.2025.01.053

Gold, Jeremy A. W., Kaitlin Benedict, and Shari R. Lipner. "Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States." Journal of the American Academy of Dermatology 92, no. 5 (2025). https://doi.org/10.1016/j.jaad.2025.01.053.

Gold, Jeremy A. W., et al. "Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States." Journal of the American Academy of Dermatology, vol. 92, no. 5, 2025. Stacks. https://doi.org/10.1016/j.jaad.2025.01.053.
Export RIS Citation Information. TY - Journal Article AU - Gold, Jeremy A. W. AU - Benedict, Kaitlin AU - Lipner, Shari R. AB - Letter to the editor to discuss diagnosing superficial dermatomycoses tinea nigra, white piedra, and black piedra. AB - Author manuscript AN - cdc:261736 C4 - PMC12009188 DO - https://doi.org/10.1016/j.jaad.2025.01.053 IS - 5 J2 - Journal of the American Academy of Dermatology KW - Tinea KW - Dermatomycoses KW - tinea nigra KW - biopsy KW - black piedra KW - culture KW - direct microscopy KW - epidemiology KW - fluconazole KW - griseofulvin KW - histopathology KW - itraconazole KW - ketoconazole KW - polymerase chain reaction KW - selenium sulfide KW - terbinafine KW - tinea nigra KW - treatment KW - United States KW - white piedra KW - Tinea KW - Dermatomycoses KW - tinea nigra LA - eng PY - 2025 T2 - Journal of the American Academy of Dermatology T2 - Journal of the American Academy of Dermatology, 2025, v. 92, no. 5 TI - Analysis of Epidemiology and Health Care Utilization For Tinea Nigra, White Piedra, and Black Piedra Among 39.4 Million Commercially Insured Outpatients, United States. VL - 92 UR - https://stacks.cdc.gov/view/cdc/261736 ER -
Ways to Measure Metals: From ICP-MS to XRF.

Adesina, Kolawole E. ;

Burgos, Chandler J.

January 2025 | Current Environmental Health Reports, 2025, v. 12, no. 1

This review explores the use of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and X-ray Fluorescence (XRF) for quantifying metals and metalloids in biological matrices such as hair, nails, blood, bone, and tissue. It provides a comprehensive overview of these methodologies, detailing their technological limitations, application scopes, and ...

10/09/2026

Supporting Files

Title : Ways to Measure Metals: From ICP-MS to XRF. Personal Author(s) : Adesina, Kolawole E.;Burgos, Chandler J.;Grier, Thomas R.;Mohammed, Abu S.;Specht, Aaron J.; Published Date : January 2025 Pages in Document : 7 (30 pdf pages) Source : Current Environmental Health Reports, 2025, v. 12, no. 1 DOI : https://doi.org/10.1007/s40572-025-00473-y Journal Title : Current Environmental Health Reports
Adesina, K. E., Burgos, C. J., Grier, T. R., Mohammed, A. S., & Specht, A. J. (2025). Ways to Measure Metals: From ICP-MS to XRF. Current Environmental Health Reports, 12(1). https://doi.org/10.1007/s40572-025-00473-y

Adesina, Kolawole E., Chandler J. Burgos, Thomas R. Grier, Abu S. Mohammed, and Aaron J. Specht. "Ways to Measure Metals: From ICP-MS to XRF." Current Environmental Health Reports 12, no. 1 (2025). https://doi.org/10.1007/s40572-025-00473-y.

Adesina, Kolawole E., et al. "Ways to Measure Metals: From ICP-MS to XRF." Current Environmental Health Reports, vol. 12, no. 1, 2025. Stacks. https://doi.org/10.1007/s40572-025-00473-y.
Export RIS Citation Information. TY - Journal Article AU - Adesina, Kolawole E. AU - Burgos, Chandler J. AU - Grier, Thomas R. AU - Mohammed, Abu S. AU - Specht, Aaron J. AB - This review explores the use of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and X-ray Fluorescence (XRF) for quantifying metals and metalloids in biological matrices such as hair, nails, blood, bone, and tissue. It provides a comprehensive overview of these methodologies, detailing their technological limitations, application scopes, and practical considerations for selection in both laboratory and field settings. By examining traditional and novel aspects of each method, this review aims to guide researchers and clinical practitioners in choosing the most suitable analytical tool based on their specific needs for sensitivity, precision, speed, and sample preparation. AB - Recent studies highlight enhanced capabilities of both ICP-MS and XRF technologies, making them more adaptable to various analytical needs. ICP-MS is renowned for its unmatched sensitivity and precision in detecting ultra-trace metals and metalloids in complex biological samples, such as lead in plasma or seawater. XRF advancements include lower detection limits and reduced sample preparation time, enabling rapid, non-destructive analyses, ideal for quick field assessments. Portable XRF analyzers have revolutionized on-the-spot testing, providing robust data without traditional wet-lab constraints. Moreover, hybrid techniques combining ICP-MS and XRF features are emerging, offering rapid and precise metal analysis for environmental monitoring, clinical diagnostics, and epidemiological studies. Matching analytical methods to specific research demands is critical. ICP-MS is the gold standard for detailed quantitative analysis in laboratories, while XRF excels in non-destructive, immediate field applications. Selection should consider sample complexity, sensitivity, speed, and cost-efficiency. Integrating ICP-MS and XRF offers a versatile approach to metals analysis, transforming practices in environmental science and healthcare diagnostics. As these technologies evolve, they are promising to expand capabilities in detecting and understanding the roles of metals and metalloids in health and the environment. AB - Author manuscript AN - cdc:261735 C4 - PMC11913532 DO - https://doi.org/10.1007/s40572-025-00473-y IS - 1 J2 - Current Environmental Health Reports KW - Mass Spectrometry KW - Metals KW - Humans KW - Environmental Monitoring KW - Metalloids KW - Spectrometry, X-Ray Emission KW - Metals KW - quantification KW - XRF KW - ICP-MS KW - biological samples KW - elements KW - spectrometry KW - Mass Spectrometry KW - Metals KW - Humans KW - Spectrometry, X-Ray Emission KW - Environmental Monitoring KW - Metalloids LA - eng PY - 2025 T2 - Current Environmental Health Reports T2 - Current Environmental Health Reports, 2025, v. 12, no. 1 TI - Ways to Measure Metals: From ICP-MS to XRF. VL - 12 UR - https://stacks.cdc.gov/view/cdc/261735 ER -
Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok.

Ball, Coltin ;

Watkins, Shannon Lea

December 2024 | SSM. Qualitative Research in Health, 2024, v. 6

Nicotine and tobacco use disproportionally affects sexual and gender minority (SGM) populations in the United States. Social media narratives may contribute to these disparities. This qualitative study delineated perceptions and experiences depicted in SGM-related videos about nicotine vaping on TikTok. Young adult researchers engaged in every step ...

10/09/2026

Supporting Files

Title : Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok. Personal Author(s) : Ball, Coltin;Watkins, Shannon Lea;Fahrion, Alexis;Morales, Makayla;McDonald, Abigail;Vogel, Erin A.;Kim, Minji; Published Date : December 2024 Pages in Document : 23 pdf pages Source : SSM. Qualitative Research in Health, 2024, v. 6 DOI : https://doi.org/10.1016/j.ssmqr.2024.100471 Journal Title : SSM. Qualitative Research in Health
Ball, C., Watkins, S. L., Fahrion, A., Morales, M., McDonald, A., Vogel, E. A., & Kim, M. (2024). Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok. SSM. Qualitative Research in Health, 6. https://doi.org/10.1016/j.ssmqr.2024.100471

Ball, Coltin, Shannon Lea Watkins, Alexis Fahrion, Makayla Morales, Abigail McDonald, Erin A. Vogel, and Minji Kim. "Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok." SSM. Qualitative Research in Health 6 (2024). https://doi.org/10.1016/j.ssmqr.2024.100471.

Ball, Coltin, et al. "Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok." SSM. Qualitative Research in Health, vol. 6, 2024. Stacks. https://doi.org/10.1016/j.ssmqr.2024.100471.
Export RIS Citation Information. TY - Journal Article AU - Ball, Coltin AU - Watkins, Shannon Lea AU - Fahrion, Alexis AU - Morales, Makayla AU - McDonald, Abigail AU - Vogel, Erin A. AU - Kim, Minji AB - Nicotine and tobacco use disproportionally affects sexual and gender minority (SGM) populations in the United States. Social media narratives may contribute to these disparities. This qualitative study delineated perceptions and experiences depicted in SGM-related videos about nicotine vaping on TikTok. Young adult researchers engaged in every step of the research process, adding an insider perspective. Using four TikTok accounts, we used vaping and SGM-related search terms to sample videos in March-April 2022. Three TikTok accounts collected SGM-specific videos; a fourth provided non-SGM specific videos for comparison. We iteratively sorted 303 unique videos into 32 AB - and emergent codes and identified themes in SGM videos and comparison videos. In their videos, creators displayed awareness of and ambivalence toward vaping and nicotine dependence. SGM videos reflected vaping as a salient feature of identity and a consideration in romantic partnership. Studying video-based social media platforms, like TikTok, using an insider-engaged qualitative lens promotes rich interpretation of content to identify prevalent and emerging messages, which can inform appropriate interventions for SGM young people. AB - Author manuscript AN - cdc:261734 C4 - PMC11759318 DO - https://doi.org/10.1016/j.ssmqr.2024.100471 J2 - SSM. Qualitative Research in Health KW - Social Media KW - Heterosexuality KW - Mental Health KW - Sexual and Gender Minorities KW - Mental Disorders KW - Brain KW - Adolescent Health KW - Electronic Nicotine Delivery Systems KW - Substance-Related Disorders KW - Nicotine KW - Transgender Persons KW - Vaping KW - Advertising KW - Cigarette Smoking KW - LGBTQ+ KW - E-cigarettes KW - Electronic cigarettes KW - Social media KW - Adolescent health KW - Young adult KW - Qualitative analysis KW - TikTok KW - Sexual and Gender Minorities KW - Electronic Nicotine Delivery Systems KW - Social Media KW - Adolescent Health KW - Advertising KW - Cigarette Smoking KW - Heterosexuality KW - Mental Health KW - Nicotine KW - Transgender Persons KW - Vaping KW - Mental Disorders KW - Substance-Related Disorders KW - Brain LA - eng PY - 2024 T2 - SSM. Qualitative Research in Health T2 - SSM. Qualitative Research in Health, 2024, v. 6 TI - Do All Bisexuals Have This Power? : an Exploratory Study of Crippling Nicotine Addiction, Identity, and Other Emergent Themes in Vaping Messages on QueerTok. VL - 6 UR - https://stacks.cdc.gov/view/cdc/261734 ER -
Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019.

Villamil, Vanessa I. ;

Downing, Karrie F.

February 2025 | Birth Defects Research, 2025, v. 117, no. 2

Almost half of individuals born with Down syndrome (DS) have congenital heart defects (CHDs). Yet, little is known about the health and healthcare needs of adults with CHDs and DS. Therefore, we examined comorbidities and healthcare utilization of this population.Data were from the 2016-2019 Congenital Heart Survey to Recognize Outcomes, Needs, and ...

10/09/2026

Supporting Files

Title : Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019. Personal Author(s) : Villamil, Vanessa I.;Downing, Karrie F.;Oster, Matthew E.;Andrews, Jennifer G.;Galindo, Maureen K.;Patel, Jenil;Klewer, Scott E.;Nembhard, Wendy N.;Farr, Sherry L.; Published Date : February 2025 Pages in Document : e2439 (14 pdf pages) Source : Birth Defects Research, 2025, v. 117, no. 2 DOI : https://doi.org/10.1002/bdr2.2439 Journal Title : Birth Defects Research
Villamil, V. I., Downing, K. F., Oster, M. E., Andrews, J. G., Galindo, M. K., Patel, J., Klewer, S. E., Nembhard, W. N., & Farr, S. L. (2025). Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019. Birth Defects Research, 117(2). https://doi.org/10.1002/bdr2.2439

Villamil, Vanessa I., Karrie F. Downing, Matthew E. Oster, Jennifer G. Andrews, Maureen K. Galindo, Jenil Patel, Scott E. Klewer, Wendy N. Nembhard, and Sherry L. Farr. "Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019." Birth Defects Research 117, no. 2 (2025). https://doi.org/10.1002/bdr2.2439.

Villamil, Vanessa I., et al. "Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019." Birth Defects Research, vol. 117, no. 2, 2025. Stacks. https://doi.org/10.1002/bdr2.2439.
Export RIS Citation Information. TY - Journal Article AU - Villamil, Vanessa I. AU - Downing, Karrie F. AU - Oster, Matthew E. AU - Andrews, Jennifer G. AU - Galindo, Maureen K. AU - Patel, Jenil AU - Klewer, Scott E. AU - Nembhard, Wendy N. AU - Farr, Sherry L. AB - Almost half of individuals born with Down syndrome (DS) have congenital heart defects (CHDs). Yet, little is known about the health and healthcare needs of adults with CHDs and DS. Therefore, we examined comorbidities and healthcare utilization of this population. AB - Data were from the 2016-2019 Congenital Heart Survey to Recognize Outcomes, Needs, and well-beinG (CH STRONG), a survey of 19-38-year-olds with CHDs identified through birth defects registries in Arkansas, Arizona, and Atlanta. Outcome estimates were standardized to the CH STRONG eligible population. Multivariable Poisson regression generated adjusted prevalence ratios (aPRs) for associations between DS and each outcome, adjusting for covariates, including CHD severity. AB - Among 1500 respondents, 9.1% had DS. Compared to those without DS, respondents with DS were more commonly male (55.5% vs. 45.0%), < 25 years old (51.8% vs. 42.7%), non-Hispanic White (72.3% vs. 69.3%), and publicly insured (77.4% vs. 22.8%; all p < 0.05). Of adults with CHDs and DS, 5.5% had cardiac comorbidities, 19.3% had emergency room (ER) visits, 6.2% had hospital admissions, and 1.2% had cost-related delays in care in the last year; 0.1 to 0.6 times lower than adults with CHDs without DS. Additionally, 26.7% had non-cardiac comorbidities (aPR = 1.25 [0.92-1.72]), most commonly sleep apnea (13.7% vs. 3.2%, aPR = 3.67 [2.02-6.67]). Receipt of cardiology care in the last 2 years was similarly low (52.7% vs. 44.7%). AB - Adults with CHDs and DS comprise a substantial percentage of adults with CHDs and have unique health and healthcare needs. Half of adults with CHDs and DS are not receiving recommended routine cardiac care. AB - Author manuscript AN - cdc:261733 C4 - PMC11837948 DO - https://doi.org/10.1002/bdr2.2439 IS - 2 J2 - Birth Defects Research KW - Surveys and Questionnaires KW - Female KW - Down Syndrome KW - Heart Defects, Congenital KW - Prevalence KW - Male KW - Comorbidity KW - Humans KW - Young Adult KW - Adult KW - Patient Acceptance of Health Care KW - cardiology KW - congenital heart defects KW - Down syndrome KW - healthcare utilization KW - Humans KW - Down Syndrome KW - Heart Defects, Congenital KW - Male KW - Female KW - Adult KW - Comorbidity KW - Patient Acceptance of Health Care KW - Young Adult KW - Surveys and Questionnaires KW - Prevalence LA - eng PY - 2025 T2 - Birth Defects Research T2 - Birth Defects Research, 2025, v. 117, no. 2 TI - Comorbidities and Healthcare Utilization Among Young Adults With Congenital Heart Defects by Down Syndrome Status-Congenital Heart Survey to Recognize Outcomes, Needs, and WellbeinG, 2016-2019. VL - 117 UR - https://stacks.cdc.gov/view/cdc/261733 ER -
Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production.

Little, Danielle T. ;

Howard, Caitlin M.

March 2025 | American Journal of Physiology. Cell Physiology, 2025, v. 328, no. 3

During acute myocardial infarction, the composition of the extracellular matrix changes remarkably. One of the most notable changes in the extracellular matrix is in the accumulation of collagen; however, hyaluronan rivals collagen in its abundance. Yet, the extent to which specific cells and enzymes may contribute to such accumulation has been lar ...

10/09/2026

Supporting Files

Title : Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production. Personal Author(s) : Little, Danielle T.;Howard, Caitlin M.;Pendergraft, Emma;Brittian, Kenneth R.;Audam, Timothy N.;Lukudu, Exile W.;Smith, Juliette;Nguyen, Daniel;Nishida, Yoshihiro;Yamaguchi, Yu;Brainard, Robert E.;Singhal, Richa A.;Jones, Steven P.; Published Date : March 2025 Pages in Document : C939-C953 (27 pdf pages) Source : American Journal of Physiology. Cell Physiology, 2025, v. 328, no. 3 DOI : https://doi.org/10.1152/ajpcell.00786.2024 Journal Title : American Journal of Physiology. Cell Physiology
Little, D. T., Howard, C. M., Pendergraft, E., Brittian, K. R., Audam, T. N., Lukudu, E. W., Smith, J., Nguyen, D., Nishida, Y., Yamaguchi, Y., Brainard, R. E., Singhal, R. A., & Jones, S. P. (2025). Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production. American Journal of Physiology. Cell Physiology, 328(3). https://doi.org/10.1152/ajpcell.00786.2024

Little, Danielle T., Caitlin M. Howard, Emma Pendergraft, Kenneth R. Brittian, Timothy N. Audam, Exile W. Lukudu, and Juliette Smith, et al.. "Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production." American Journal of Physiology. Cell Physiology 328, no. 3 (2025). https://doi.org/10.1152/ajpcell.00786.2024.

Little, Danielle T., et al. "Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production." American Journal of Physiology. Cell Physiology, vol. 328, no. 3, 2025. Stacks. https://doi.org/10.1152/ajpcell.00786.2024.
Export RIS Citation Information. TY - Journal Article AU - Little, Danielle T. AU - Howard, Caitlin M. AU - Pendergraft, Emma AU - Brittian, Kenneth R. AU - Audam, Timothy N. AU - Lukudu, Exile W. AU - Smith, Juliette AU - Nguyen, Daniel AU - Nishida, Yoshihiro AU - Yamaguchi, Yu AU - Brainard, Robert E. AU - Singhal, Richa A. AU - Jones, Steven P. AB - During acute myocardial infarction, the composition of the extracellular matrix changes remarkably. One of the most notable changes in the extracellular matrix is in the accumulation of collagen; however, hyaluronan rivals collagen in its abundance. Yet, the extent to which specific cells and enzymes may contribute to such accumulation has been largely unexplored. Here, we hypothesized that activated cardiac fibroblasts produce hyaluronan via hyaluronan synthase 2 (HAS2). We show that hyaluronan accumulates following myocardial infarction and persists through at least 4 wk. Our analyses of failing heart RNA sequencing data suggest that fibroblasts are the cells most changed in the expression of AB - . Given these insights, we used HAS2 gain- and loss-of-function approaches to examine the extent to which activated cardiac fibroblasts produce hyaluronan. Transforming growth factor β (TGFβ)-induced activation of fibroblasts caused a significant increase in AB - mRNA and concomitant accumulation of hyaluronan >1 MDa in size. Deletion of AB - abrogated TGFβ-induced production of hyaluronan. In addition, overexpression of AB - was sufficient to cause an increase in hyaluronan accumulation in the absence of TGFβ-induced activation. Our data indicated negligible impacts of AB - on proliferation, migration, and collagen production. Exposing fibroblasts to exogenous hyaluronan also had minimal impact on fibroblasts. We also assessed whether fibroblast-borne AB - plays a role in the degradation of hyaluronan, and our data indicated little impact of AB - on hyaluronan accumulation (or even any impacts on the transcriptional profile of fibroblasts). Activated fibroblasts produce high-molecular-weight hyaluronan via AB - , which occurs independent of other fibroblast functions. AB - Activated cardiac fibroblasts produce copious quantities of collagen, and much is known about this process. They also produce hyaluronan, which is abundant in the extracellular matrix, but less is known about hyaluronan. Here, we identify cardiac fibroblasts as major producers of hyaluronan and, specifically, that they produce high-molecular-weight hyaluronan via HAS2. This has important implications for ventricular remodeling and for metabolic regulation of activated fibroblasts, as they produce this abundant matrix component. AB - Author manuscript AN - cdc:261732 C4 - PMC12172657 DO - https://doi.org/10.1152/ajpcell.00786.2024 IS - 3 J2 - American Journal of Physiology. Cell Physiology KW - Transforming Growth Factor beta KW - Myocardium KW - Animals KW - Molecular Weight KW - Collagen KW - Myocardial Infarction KW - Mice, Inbred C57BL KW - Cells, Cultured KW - Hyaluronic Acid KW - Cell Proliferation KW - Hyaluronan Synthases KW - Male KW - Extracellular Matrix KW - Fibroblasts KW - Mice KW - Fibrosis KW - Extracellular Matrix KW - Heart Failure KW - Myocardial Infarction KW - Hyaluronic Acid KW - Animals KW - Hyaluronan Synthases KW - Fibroblasts KW - Myocardium KW - Myocardial Infarction KW - Mice KW - Molecular Weight KW - Transforming Growth Factor beta KW - Extracellular Matrix KW - Male KW - Cell Proliferation KW - Mice, Inbred C57BL KW - Cells, Cultured KW - Collagen LA - eng PY - 2025 T2 - American Journal of Physiology. Cell Physiology T2 - American Journal of Physiology. Cell Physiology, 2025, v. 328, no. 3 TI - Activated Cardiac Fibroblasts Are a Primary Source of High-molecular-weight Hyaluronan Production. VL - 328 UR - https://stacks.cdc.gov/view/cdc/261732 ER -
Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles.

Beaudreau, Marc ;

Srikanth, Pranav

April 2025 | Journal of Occupational and Environmental Hygiene, 2025, v. 22, no. 4

Recently, the misuse of fentanyl and methamphetamine has increased in the United States. These drugs can be consumed via smoking a powder, which can subsequently contaminate air and surfaces with drug residue. With limited access to safe consumption sites, this misuse often occurs in public spaces such as public transit, leading to potential second ...

10/09/2026

Supporting Files

Title : Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles. Personal Author(s) : Beaudreau, Marc;Srikanth, Pranav;Zuidema, Christopher;Cohen, Martin A.;Seto, Edmund;Simpson, Christopher D.;Baker, Marissa G.; Published Date : April 2025 Pages in Document : 300-310 (18 pdf pages) Source : Journal of Occupational and Environmental Hygiene, 2025, v. 22, no. 4 DOI : https://doi.org/10.1080/15459624.2024.2444430 Journal Title : Journal of Occupational and Environmental Hygiene
Beaudreau, M., Srikanth, P., Zuidema, C., Cohen, M. A., Seto, E., Simpson, C. D., & Baker, M. G. (2025). Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles. Journal of Occupational and Environmental Hygiene, 22(4). https://doi.org/10.1080/15459624.2024.2444430

Beaudreau, Marc, Pranav Srikanth, Christopher Zuidema, Martin A. Cohen, Edmund Seto, Christopher D. Simpson, and Marissa G. Baker. "Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles." Journal of Occupational and Environmental Hygiene 22, no. 4 (2025). https://doi.org/10.1080/15459624.2024.2444430.

Beaudreau, Marc, et al. "Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles." Journal of Occupational and Environmental Hygiene, vol. 22, no. 4, 2025. Stacks. https://doi.org/10.1080/15459624.2024.2444430.
Export RIS Citation Information. TY - Journal Article AU - Beaudreau, Marc AU - Srikanth, Pranav AU - Zuidema, Christopher AU - Cohen, Martin A. AU - Seto, Edmund AU - Simpson, Christopher D. AU - Baker, Marissa G. AB - Recently, the misuse of fentanyl and methamphetamine has increased in the United States. These drugs can be consumed via smoking a powder, which can subsequently contaminate air and surfaces with drug residue. With limited access to safe consumption sites, this misuse often occurs in public spaces such as public transit, leading to potential secondhand exposures among transit operators and riders. In the Pacific Northwest, transit operators have reported acute health symptoms and safety concerns regarding these drug exposures. Researchers conducted an exposure assessment, sampling air and surfaces for fentanyl and methamphetamine. A total of 78 air samples and 89 surface samples were collected on 11 buses and 19 train cars from four transit agencies in the Pacific Northwest. Fentanyl was detected above the limit of quantification (LOQ) in 25% of air samples (range of concentrations > LOQ: 0.002 to 0.14 µg/m AB - ) and 38% of surface samples (range of concentrations > LOQ: 0.011 to 0.47 ng/cm AB - ), while methamphetamine was detected in 100% of air samples (range: 0.003 to 2.32 µg/m AB - ) and 98% of surface samples (range of concentrations > LOQ: 0.016 to 6.86 ng/cm AB - ) The highest fentanyl air sample (0.14 µg/m AB - ) was collected in the passenger area of a train for 4 hr, and would exceed the ACGIH AB - 8-hr TWA TLV AB - of 0.1 µg/m AB - if conditions remained the same for the unsampled period. No surface samples exceed the ACGIH fentanyl surface level TLV (10 ng/cm AB - ). The prevalence of fentanyl and methamphetamine on public transit highlights the need to protect transit operators from secondhand exposure and from the stress of witnessing and responding to smoking events. Future work is needed to evaluate the utility of engineering and administrative controls such as ventilation and cleaning upgrades in reducing exposures on transit, as well as the utility of training and increased workplace support for operators in addressing their health and well-being after observing or responding to drug use events. AB - Author manuscript AN - cdc:261731 C4 - PMC11981843 DO - https://doi.org/10.1080/15459624.2024.2444430 IS - 4 J2 - Journal of Occupational and Environmental Hygiene KW - Occupational Exposure KW - Motor Vehicles KW - Air Pollution, Indoor KW - Fentanyl KW - Methamphetamine KW - Humans KW - Environmental Monitoring KW - Exposure assessment KW - Occupational exposures KW - Transit operators KW - Fentanyl KW - Methamphetamine KW - Humans KW - Environmental Monitoring KW - Occupational Exposure KW - Air Pollution, Indoor KW - Motor Vehicles LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Hygiene T2 - Journal of Occupational and Environmental Hygiene, 2025, v. 22, no. 4 TI - Assessing Fentanyl and Methamphetamine in Air and on Surfaces of Transit Vehicles. VL - 22 UR - https://stacks.cdc.gov/view/cdc/261731 ER -
Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023.

Barger, Alexandra ;

Duncan, Jennifer

July 2025 | American Journal of Infection Control, 2025, v. 53, no. 7

A certified nursing assistant at a long-term care facility worked 3 shifts while infectious with monkeypox virus providing direct care to facility residents. Despite exposures and a delay of 16days from symptom onset to diagnosis and public health notification, there is no evidence of transmission. We describe details of this health care-associated ...

10/09/2026

Supporting Files

Title : Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023. Personal Author(s) : Barger, Alexandra;Duncan, Jennifer;Traore, Dalen;Smit, Mattheus;Thoroughman, Douglas;Winter, Kathleen; Published Date : July 2025 Pages in Document : 797-798 (5 pdf pages) Source : American Journal of Infection Control, 2025, v. 53, no. 7 DOI : https://doi.org/10.1016/j.ajic.2025.01.016 Journal Title : American Journal of Infection Control
Barger, A., Duncan, J., Traore, D., Smit, M., Thoroughman, D., & Winter, K. (2025). Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023. American Journal of Infection Control, 53(7). https://doi.org/10.1016/j.ajic.2025.01.016

Barger, Alexandra, Jennifer Duncan, Dalen Traore, Mattheus Smit, Douglas Thoroughman, and Kathleen Winter. "Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023." American Journal of Infection Control 53, no. 7 (2025). https://doi.org/10.1016/j.ajic.2025.01.016.

Barger, Alexandra, et al. "Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023." American Journal of Infection Control, vol. 53, no. 7, 2025. Stacks. https://doi.org/10.1016/j.ajic.2025.01.016.
Export RIS Citation Information. TY - Journal Article AU - Barger, Alexandra AU - Duncan, Jennifer AU - Traore, Dalen AU - Smit, Mattheus AU - Thoroughman, Douglas AU - Winter, Kathleen AB - A certified nursing assistant at a long-term care facility worked 3 shifts while infectious with monkeypox virus providing direct care to facility residents. Despite exposures and a delay of 16days from symptom onset to diagnosis and public health notification, there is no evidence of transmission. We describe details of this health care-associated exposure, public health response, situational risk factors for transmission, and discuss factors that might have contributed to the lack of transmission. AB - Author manuscript AN - cdc:261730 C4 - PMC12167686 DO - https://doi.org/10.1016/j.ajic.2025.01.016 IS - 7 J2 - American Journal of Infection Control KW - Female KW - Nursing Assistants KW - Nursing Homes KW - Risk Factors KW - Male KW - Aged KW - Monkeypox virus KW - Humans KW - Mpox, Monkeypox KW - Long-Term Care KW - Cross Infection KW - Monkeypox virus KW - Hospital epidemiology KW - Healthcare-associated infection KW - Humans KW - Long-Term Care KW - Mpox, Monkeypox KW - Male KW - Risk Factors KW - Nursing Assistants KW - Monkeypox virus KW - Female KW - Cross Infection KW - Nursing Homes KW - Aged LA - eng PY - 2025 T2 - American Journal of Infection Control T2 - American Journal of Infection Control, 2025, v. 53, no. 7 TI - Lack of Mpox Transmission in a Long-term Care Facility Despite Widespread Exposure: Kentucky, 2023. VL - 53 UR - https://stacks.cdc.gov/view/cdc/261730 ER -
Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis.

Violanti, John M. ;

Fekedulegn, Desta

April 2025 | Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 4

This study estimated risk of metabolic syndrome (MetSyn) and its components among police officers including differences by sex.Police officers were examined at baseline and two follow-up examinations after 7 and 12 years. MetSyn was defined using the 2005 guidelines from the American Heart Association/National Heart, Lung, and Blood Institute. Risk ...

10/09/2026

Supporting Files

Title : Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis. Personal Author(s) : Violanti, John M.;Fekedulegn, Desta;Mnatsakanova, Anna;Gu, Ja K.;Service, Samantha;Allison, Penelope;Hartley, Tara A.; Published Date : April 2025 Pages in Document : 285-292 (20 pdf pages) Source : Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 4 DOI : https://doi.org/10.1097/JOM.0000000000003316 Journal Title : Journal of Occupational and Environmental Medicine
Violanti, J. M., Fekedulegn, D., Mnatsakanova, A., Gu, J. K., Service, S., Allison, P., & Hartley, T. A. (2025). Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis. Journal of Occupational and Environmental Medicine, 67(4). https://doi.org/10.1097/JOM.0000000000003316

Violanti, John M., Desta Fekedulegn, Anna Mnatsakanova, Ja K. Gu, Samantha Service, Penelope Allison, and Tara A. Hartley. "Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis." Journal of Occupational and Environmental Medicine 67, no. 4 (2025). https://doi.org/10.1097/JOM.0000000000003316.

Violanti, John M., et al. "Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis." Journal of Occupational and Environmental Medicine, vol. 67, no. 4, 2025. Stacks. https://doi.org/10.1097/JOM.0000000000003316.
Export RIS Citation Information. TY - Journal Article AU - Violanti, John M. AU - Fekedulegn, Desta AU - Mnatsakanova, Anna AU - Gu, Ja K. AU - Service, Samantha AU - Allison, Penelope AU - Hartley, Tara A. AB - This study estimated risk of metabolic syndrome (MetSyn) and its components among police officers including differences by sex. AB - Police officers were examined at baseline and two follow-up examinations after 7 and 12 years. MetSyn was defined using the 2005 guidelines from the American Heart Association/National Heart, Lung, and Blood Institute. Risk for incident MetSyn and its components at follow-up exams and risk ratios in males compared to females were estimated using modified Poisson regression. AB - The 7- ( n = 276) and 12- ( n = 191) year incidence of MetSyn was 20.4% and 22.2%, respectively. MetSyn components with lowest and highest incidence were reduced HDL cholesterol and abdominal obesity. The 7-year risk of developing glucose intolerance was two-fold higher in males compared to females. AB - Longitudinal analysis of incidence of MetSyn and its components is important for understanding future cardiovascular disease morbidity and mortality. AB - Author manuscript AN - cdc:261729 C4 - PMC12614480 DO - https://doi.org/10.1097/JOM.0000000000003316 IS - 4 J2 - Journal of Occupational and Environmental Medicine KW - Longitudinal Studies KW - Glucose Intolerance KW - Female KW - Obesity, Abdominal KW - Cholesterol, HDL KW - Risk Factors KW - Sex Factors KW - Incidence KW - Police KW - Male KW - Humans KW - Middle Aged KW - Metabolic Syndrome KW - Adult KW - police KW - metabolic syndrome KW - cardiovascular disease KW - sex KW - longitudinal analysis KW - Humans KW - Metabolic Syndrome KW - Male KW - Female KW - Police KW - Longitudinal Studies KW - Adult KW - Middle Aged KW - Incidence KW - Risk Factors KW - Sex Factors KW - Cholesterol, HDL KW - Obesity, Abdominal KW - Glucose Intolerance LA - eng PY - 2025 T2 - Journal of Occupational and Environmental Medicine T2 - Journal of Occupational and Environmental Medicine, 2025, v. 67, no. 4 TI - Metabolic Syndrome and Associated Components Among Police Officers: a 7 and 12-Year Longitudinal Analysis. VL - 67 UR - https://stacks.cdc.gov/view/cdc/261729 ER -
One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation.

Silver, Rebecca B. ;

Low, Christine M.

May 2025 | Infant Mental Health Journal, 2025, v. 46, no. 3

Reflective supervision (RS) has been viewed as best practice and is therefore incorporated-and often mandated-as a key feature of many relationship-based infant and early childhood serving programs. To promote the implementation of high-quality RS for infant and early childhood professionals, it is critical that a focus is placed on how infant and ...

10/09/2026

Supporting Files

Title : One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation. Personal Author(s) : Silver, Rebecca B.;Low, Christine M.;Huffhines, Lindsay;Newland, Rebecca;Herman, Rachel;Parade, Stephanie H.; Published Date : May 2025 Pages in Document : 328-342 (27 pdf pages) Source : Infant Mental Health Journal, 2025, v. 46, no. 3 DOI : https://doi.org/10.1002/imhj.22165 Journal Title : Infant Mental Health Journal
Silver, R. B., Low, C. M., Huffhines, L., Newland, R., Herman, R., & Parade, S. H. (2025). One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation. Infant Mental Health Journal, 46(3). https://doi.org/10.1002/imhj.22165

Silver, Rebecca B., Christine M. Low, Lindsay Huffhines, Rebecca Newland, Rachel Herman, and Stephanie H. Parade. "One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation." Infant Mental Health Journal 46, no. 3 (2025). https://doi.org/10.1002/imhj.22165.

Silver, Rebecca B., et al. "One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation." Infant Mental Health Journal, vol. 46, no. 3, 2025. Stacks. https://doi.org/10.1002/imhj.22165.
Export RIS Citation Information. TY - Journal Article AU - Silver, Rebecca B. AU - Low, Christine M. AU - Huffhines, Lindsay AU - Newland, Rebecca AU - Herman, Rachel AU - Parade, Stephanie H. AB - Reflective supervision (RS) has been viewed as best practice and is therefore incorporated-and often mandated-as a key feature of many relationship-based infant and early childhood serving programs. To promote the implementation of high-quality RS for infant and early childhood professionals, it is critical that a focus is placed on how infant and early childhood professionals are trained to build RS capacities. To this end, we describe Rhode Island, United States's journey developing, implementing, and iteratively adapting an RS professional development series. We describe the structure of the curricula as well as the content and learning objectives, which strive to bridge the gap between the theoretical concepts foundational to RS, process-oriented self-reflection, and the practical application of RS skills and strategies. We also outline the development and process of iterative adaptation that has refined the curricula over the past decade. Finally, we chronicle the history of coordination and collaboration that promoted the development and implementation of this series, which has been disseminated within home visiting and early care and education settings. This narrative can serve as a model for organizations, systems, and states that are undertaking efforts to provide professional development focused on RS. AB - Author manuscript AN - cdc:261728 C4 - PMC12048261 DO - https://doi.org/10.1002/imhj.22165 IS - 3 J2 - Infant Mental Health Journal KW - Program Development KW - Infant KW - Curriculum KW - Humans KW - Child, Preschool KW - Staff Development KW - reflective supervision KW - reflective practice KW - home visiting KW - early care and education KW - implementation KW - Humans KW - Curriculum KW - Infant KW - Staff Development KW - Program Development KW - Child, Preschool LA - eng PY - 2025 T2 - Infant Mental Health Journal T2 - Infant Mental Health Journal, 2025, v. 46, no. 3 TI - One State's Journey With a Reflective Supervision Professional Development Series: Development, Implementation, and Adaptation. VL - 46 UR - https://stacks.cdc.gov/view/cdc/261728 ER -
marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection.

Chen, I-Chen

July 2025 | Journal of Exposure Science & Environmental Epidemiology, 2025, v. 35, no. 4

In environmental and occupational research, when concentration measurements are taken from the same individual or study site, they are considered to be repeated measurements. Furthermore, when these samples fall below the limit of detection (LOD) of laboratory instruments, they are referred to as left-censored repeated measures data. These unquanti ...

10/09/2026

Supporting Files

Title : marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection. Personal Author(s) : Chen, I-Chen Published Date : July 2025 Pages in Document : 630-631 (3 pdf pages) Source : Journal of Exposure Science & Environmental Epidemiology, 2025, v. 35, no. 4 DOI : https://doi.org/10.1038/s41370-025-00752-8 Journal Title : Journal of Exposure Science & Environmental Epidemiology
Chen, I. C. (2025). marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection. Journal of Exposure Science & Environmental Epidemiology, 35(4). https://doi.org/10.1038/s41370-025-00752-8

Chen, I-Chen. "marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection." Journal of Exposure Science & Environmental Epidemiology 35, no. 4 (2025). https://doi.org/10.1038/s41370-025-00752-8.

Chen, I-Chen "marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection." Journal of Exposure Science & Environmental Epidemiology, vol. 35, no. 4, 2025. Stacks. https://doi.org/10.1038/s41370-025-00752-8.
Export RIS Citation Information. TY - Journal Article AU - Chen, I-Chen AB - In environmental and occupational research, when concentration measurements are taken from the same individual or study site, they are considered to be repeated measurements. Furthermore, when these samples fall below the limit of detection (LOD) of laboratory instruments, they are referred to as left-censored repeated measures data. These unquantified measurements typically represent low-level concentrations between zero and the LOD. There is an increasing need for statistical models that can effectively analyze left-censored environmental exposure and biomonitoring data with repeated measures, particularly among industrial hygienists. This is due to the growing importance of estimating the impact of exposure on disease risk and understanding the variability in occupational exposure both within and between workers. Analytical results from laboratories, including data on environmental contaminants (e.g., from hand wipes or personal breathing zone air samples) and occupational exposures (e.g., from biological media such as urine or serum) are often subject to non-detectable concentrations and tend to exhibit right-skewed distributions. The statistical modeling of exposure data that contain both repeated samples and samples below the LOD can be complex. AB - Author manuscript AN - cdc:261727 C4 - PMC12234243 DO - https://doi.org/10.1038/s41370-025-00752-8 IS - 4 J2 - Journal of Exposure Science & Environmental Epidemiology KW - Occupational Exposure KW - Limit of Detection KW - Biological Monitoring KW - Humans KW - Laboratories KW - Urine KW - Models, Statistical KW - Marginal analysis KW - Left censoring KW - Right skewness KW - Limit of detection KW - Repeated measures KW - Humans KW - Biological Monitoring KW - Laboratories KW - Limit of Detection KW - Urine KW - Occupational Exposure KW - Models, Statistical LA - eng PY - 2025 T2 - Journal of Exposure Science & Environmental Epidemiology T2 - Journal of Exposure Science & Environmental Epidemiology, 2025, v. 35, no. 4 TI - marlod: an R Package to Model Environmental Exposure and Biomonitoring Data With Repeated Measurements and Values Below the Limit of Detection. VL - 35 UR - https://stacks.cdc.gov/view/cdc/261727 ER -
Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat.

Specht, Jonathan W. ;

Bailly, Alyssa R.

June 2025 | Medicine and Science in Sports and Exercise, 2025, v. 57, no. 6

To test the hypothesis that ibuprofen ingestion exacerbates markers of acute kidney injury (AKI), gastrointestinal (GI) injury, and endotoxemia after running in the heat.Using a randomized double-blind crossover design, 11 physically active individuals (six women) ingested 600 mg of ibuprofen or placebo 12- and 1-h before running 1 h in a heated ch ...

10/09/2026

Supporting Files

Title : Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat. Personal Author(s) : Specht, Jonathan W.;Bailly, Alyssa R.;Garcia, Serena;Klepacz, Steven;Oliveira, Suzana Andrade De;Lucero, David;McKenna, Zachary J.;Schlader, Zachary J.;Amorim, Fabiano T.; Published Date : June 2025 Pages in Document : 1092-1102 (23 pdf pages) Source : Medicine and Science in Sports and Exercise, 2025, v. 57, no. 6 DOI : https://doi.org/10.1249/MSS.0000000000003659 Journal Title : Medicine and Science in Sports and Exercise
Specht, J. W., Bailly, A. R., Garcia, S., Klepacz, S., Oliveira, S. A. D., Lucero, D., McKenna, Z. J., Schlader, Z. J., & Amorim, F. T. (2025). Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat. Medicine and Science in Sports and Exercise, 57(6). https://doi.org/10.1249/MSS.0000000000003659

Specht, Jonathan W., Alyssa R. Bailly, Serena Garcia, Steven Klepacz, Suzana Andrade De Oliveira, David Lucero, Zachary J. McKenna, Zachary J. Schlader, and Fabiano T. Amorim. "Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat." Medicine and Science in Sports and Exercise 57, no. 6 (2025). https://doi.org/10.1249/MSS.0000000000003659.

Specht, Jonathan W., et al. "Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat." Medicine and Science in Sports and Exercise, vol. 57, no. 6, 2025. Stacks. https://doi.org/10.1249/MSS.0000000000003659.
Export RIS Citation Information. TY - Journal Article AU - Specht, Jonathan W. AU - Bailly, Alyssa R. AU - Garcia, Serena AU - Klepacz, Steven AU - Oliveira, Suzana Andrade De AU - Lucero, David AU - McKenna, Zachary J. AU - Schlader, Zachary J. AU - Amorim, Fabiano T. AB - To test the hypothesis that ibuprofen ingestion exacerbates markers of acute kidney injury (AKI), gastrointestinal (GI) injury, and endotoxemia after running in the heat. AB - Using a randomized double-blind crossover design, 11 physically active individuals (six women) ingested 600 mg of ibuprofen or placebo 12- and 1-h before running 1 h in a heated chamber (35°C, 20%-60% R.H.) at an intensity of 60% V̇O 2peak . Blood and urine samples were collected preexercise, postexercise, and 1-h postexercise to assess cytokines and markers of AKI, GI injury, and endotoxemia. AB - One hour of running in the heat increased markers of AKI (urinary product of IGFBP7•TIMP2 [Placebo: ∆ 1.8 ± 0.8 log 10 (ng·mL 2 )/1000, Ibuprofen: ∆ 1.8 ± 0.9 log 10 (ng·mL 2 )/1000], urinary NGAL, and serum cystatin C), GI damage (I-FABP [Placebo: ∆ 631 ± 446 pg·mL -1 , Ibuprofen: ∆ 576 ± 455 pg·mL -1 ]), and inflammatory cytokines (TNFα [Placebo: ∆ 5.2 ± 3.5 pg·mL -1 , Ibuprofen: ∆ 6.2 ± 4.9 pg·mL -1 ], IL-6, IL-10, and MCP-1), but these changes were not exacerbated by ibuprofen ingestion. There were effects of time ( P < 0.001) and condition ( P = 0.03) for serum IL-8, with greater concentrations in the ibuprofen (pre: 11.4 ± 5.1 pg·mL -1 , post: 15.5 ± 7.3 pg·mL -1 ) trials than placebo (pre: 9.7 ± 4.2 pg·mL -1 , post: 11.7 ± 5.4 pg·mL -1 ). There were no effects of time or condition on markers of endotoxemia (LBP [Placebo: ∆ -1.2 ± 3.2 μg·mL -1 , Ibuprofen: ∆ 1.0 ± 1.6 μg·mL -1 ], sCD14). AB - These findings indicate that ibuprofen ingestion does not worsen intestinal or renal injury experienced during 1 h of exercise in the heat, but increases pro-inflammatory IL-8. AB - Author manuscript AN - cdc:261726 C4 - PMC12101219 DO - https://doi.org/10.1249/MSS.0000000000003659 IS - 6 J2 - Medicine and Science in Sports and Exercise KW - Double-Blind Method KW - Lipocalin-2 KW - Female KW - Tissue Inhibitor of Metalloproteinase-2 KW - Young Adult KW - Lipocalins KW - Cytokines KW - Cross-Over Studies KW - Anti-Inflammatory Agents, Non-Steroidal KW - Biomarkers KW - Hot Temperature KW - Fatty Acid-Binding Proteins KW - Acute-Phase Proteins KW - Acute Kidney Injury KW - Running KW - Male KW - Humans KW - Adult KW - Endotoxemia KW - Ibuprofen KW - CYTOKINE KW - EXERCISE KW - EXERTIONAL HEAT STRESS KW - NSAID KW - Humans KW - Ibuprofen KW - Acute Kidney Injury KW - Endotoxemia KW - Biomarkers KW - Female KW - Double-Blind Method KW - Cross-Over Studies KW - Male KW - Running KW - Adult KW - Hot Temperature KW - Lipocalin-2 KW - Cytokines KW - Anti-Inflammatory Agents, Non-Steroidal KW - Young Adult KW - Fatty Acid-Binding Proteins KW - Tissue Inhibitor of Metalloproteinase-2 KW - Lipocalins KW - Acute-Phase Proteins LA - eng PY - 2025 T2 - Medicine and Science in Sports and Exercise T2 - Medicine and Science in Sports and Exercise, 2025, v. 57, no. 6 TI - Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat. VL - 57 UR - https://stacks.cdc.gov/view/cdc/261726 ER -
Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort.

Ramachandran, Rithambara ;

Lu, Ming-Chen

May 2025 | Journal of Glaucoma, 2025, v. 34, no. 5

Current optical coherence tomography normative sample data may not represent the diversity of human optic nerve anatomy needed to accurately classify all individuals with true glaucomatous optic neuropathy.To compare optic nerve head (ONH) measurements between published values from an optical coherence tomography (OCT) normative database and a larg ...

10/09/2026

Supporting Files

Title : Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort. Personal Author(s) : Ramachandran, Rithambara;Lu, Ming-Chen;Niziol, Leslie M.;Woodward, Maria A.;Elam, Angela R.;Johnson, Leroy;Kershaw, Martha;Musch, David C.;Bicket, Amanda;John, Denise;Wood, Sarah Dougherty;Zhang, Amy;Zhang, Jason;O'Brien, Joan;Newman-Casey, Paula Anne; Published Date : May 2025 Pages in Document : 404-414 (22 pdf pages) Source : Journal of Glaucoma, 2025, v. 34, no. 5 DOI : https://doi.org/10.1097/IJG.0000000000002545 Journal Title : Journal of Glaucoma
Ramachandran, R., Lu, M. C., Niziol, L. M., Woodward, M. A., Elam, A. R., Johnson, L., Kershaw, M., Musch, D. C., Bicket, A., John, D., Wood, S. D., Zhang, A., Zhang, J., O'Brien, J., & Newman-Casey, P. A. (2025). Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort. Journal of Glaucoma, 34(5). https://doi.org/10.1097/IJG.0000000000002545

Ramachandran, Rithambara, Ming-Chen Lu, Leslie M. Niziol, Maria A. Woodward, Angela R. Elam, Leroy Johnson, and Martha Kershaw, et al.. "Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort." Journal of Glaucoma 34, no. 5 (2025). https://doi.org/10.1097/IJG.0000000000002545.

Ramachandran, Rithambara, et al. "Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort." Journal of Glaucoma, vol. 34, no. 5, 2025. Stacks. https://doi.org/10.1097/IJG.0000000000002545.
Export RIS Citation Information. TY - Journal Article AU - Ramachandran, Rithambara AU - Lu, Ming-Chen AU - Niziol, Leslie M. AU - Woodward, Maria A. AU - Elam, Angela R. AU - Johnson, Leroy AU - Kershaw, Martha AU - Musch, David C. AU - Bicket, Amanda AU - John, Denise AU - Wood, Sarah Dougherty AU - Zhang, Amy AU - Zhang, Jason AU - O'Brien, Joan AU - Newman-Casey, Paula Anne AB - Current optical coherence tomography normative sample data may not represent the diversity of human optic nerve anatomy needed to accurately classify all individuals with true glaucomatous optic neuropathy. AB - To compare optic nerve head (ONH) measurements between published values from an optical coherence tomography (OCT) normative database and a larger, more diverse cohort of healthy individuals. AB - ONH parameters from healthy participants of the Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program and the Topcon Maestro-1 normative cohort were compared. χ 2 tests compared MI-SIGHT retinal nerve fiber layer (RNFL) quadrant color-code labels with the expected distribution and multinomial logistic regression identified factors associated with label classifications. AB - In all, 1084 MI-SIGHT and 399 Topcon eyes were evaluated. The MI-SIGHT cohort was older (54 vs. 46 y), with more individuals identifying as black (61% vs. 20%), fewer as Hispanic (4% vs. 18%), and spherical equivalents closer to plano (-0.6 vs. -1.2 diopters) compared to the Topcon cohort (all P <0.001). Black/African American MI-SIGHT participants had larger cup-to-disc ratios and cup volumes, while white MI-SIGHT participants had smaller ONH values, except for rim area and rim volume, compared to Topcon participants (all P <0.001). The MI-SIGHT cohort's RNFL color codes did not follow the expected distribution ( P <0.05); more MI-SIGHT RNFL quadrant measurements were assigned as white (10.6% and 6.3% MI-SIGHT vs. 5% Topcon) and red codes (2.2% and 1.8% MI-SIGHT vs. <1% Topcon) than expected in the superior and inferior quadrants, respectively. AB - OCT normative databases should accurately reflect diverse populations to avoid misclassification by RNFL thickness color codes. Larger data sets should be leveraged to encompass the full spectrum of healthy optic nerve anatomy. AB - Author manuscript AN - cdc:261725 C4 - PMC12021544 DO - https://doi.org/10.1097/IJG.0000000000002545 IS - 5 J2 - Journal of Glaucoma KW - Reference Values KW - Female KW - Visual Fields KW - Glaucoma KW - Aged KW - Optic Disk KW - Retinal Ganglion Cells KW - Databases, Factual KW - Nerve Fibers KW - Optic Nerve Diseases KW - Male KW - Middle Aged KW - Humans KW - Tomography, Optical Coherence KW - Intraocular Pressure KW - Adult KW - Optical Coherence Tomography (OCT) KW - glaucoma KW - screening KW - normative data KW - big data KW - bias KW - diversity KW - Humans KW - Optic Disk KW - Tomography, Optical Coherence KW - Male KW - Middle Aged KW - Female KW - Nerve Fibers KW - Retinal Ganglion Cells KW - Databases, Factual KW - Optic Nerve Diseases KW - Aged KW - Adult KW - Intraocular Pressure KW - Glaucoma KW - Reference Values KW - Visual Fields LA - eng PY - 2025 T2 - Journal of Glaucoma T2 - Journal of Glaucoma, 2025, v. 34, no. 5 TI - Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort. VL - 34 UR - https://stacks.cdc.gov/view/cdc/261725 ER -

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