Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat.

Details

• Alternative Title:
  Medicine and Science in Sports and Exercise, 2025, v. 57, no. 6: Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia After Running in the Heat.
• Journal Article:
  Medicine and Science in Sports and Exercise
• Personal Author:
  Specht, Jonathan W. ; Bailly, Alyssa R. ; Garcia, Serena ; Klepacz, Steven ; Oliveira, Suzana Andrade De ; Lucero, David ; McKenna, Zachary J. ; Schlader, Zachary J. ; Amorim, Fabiano T.
• Description:
  To test the hypothesis that ibuprofen ingestion exacerbates markers of acute kidney injury (AKI), gastrointestinal (GI) injury, and endotoxemia after running in the heat.
  
  Using a randomized double-blind crossover design, 11 physically active individuals (six women) ingested 600 mg of ibuprofen or placebo 12- and 1-h before running 1 h in a heated chamber (35°C, 20%-60% R.H.) at an intensity of 60% V̇O 2peak . Blood and urine samples were collected preexercise, postexercise, and 1-h postexercise to assess cytokines and markers of AKI, GI injury, and endotoxemia.
  
  One hour of running in the heat increased markers of AKI (urinary product of IGFBP7•TIMP2 Placebo: ∆ 1.8 ± 0.8 log 10 (ng·mL 2 )/1000, Ibuprofen: ∆ 1.8 ± 0.9 log 10 (ng·mL 2 )/1000, urinary NGAL, and serum cystatin C), GI damage (I-FABP Placebo: ∆ 631 ± 446 pg·mL -1 , Ibuprofen: ∆ 576 ± 455 pg·mL -1 ), and inflammatory cytokines (TNFα Placebo: ∆ 5.2 ± 3.5 pg·mL -1 , Ibuprofen: ∆ 6.2 ± 4.9 pg·mL -1 , IL-6, IL-10, and MCP-1), but these changes were not exacerbated by ibuprofen ingestion. There were effects of time ( P < 0.001) and condition ( P = 0.03) for serum IL-8, with greater concentrations in the ibuprofen (pre: 11.4 ± 5.1 pg·mL -1 , post: 15.5 ± 7.3 pg·mL -1 ) trials than placebo (pre: 9.7 ± 4.2 pg·mL -1 , post: 11.7 ± 5.4 pg·mL -1 ). There were no effects of time or condition on markers of endotoxemia (LBP Placebo: ∆ -1.2 ± 3.2 μg·mL -1 , Ibuprofen: ∆ 1.0 ± 1.6 μg·mL -1 , sCD14).
  
  These findings indicate that ibuprofen ingestion does not worsen intestinal or renal injury experienced during 1 h of exercise in the heat, but increases pro-inflammatory IL-8.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Ibuprofen
  • Acute Kidney Injury
  • Endotoxemia
  • Biomarkers
  • Female
  • Double-Blind Method
  • Cross-Over Studies
  • Male
  • Running
  More +
• Keywords:
  • CYTOKINE
  • EXERCISE
  • EXERTIONAL HEAT STRESS
  • NSAID
• Source:
  Medicine and Science in Sports and Exercise, 2025, v. 57, no. 6
• DOI:
  https://doi.org/10.1249/MSS.0000000000003659
• ISSN:
  0195-9131 ; 1530-0315
• Pubmed ID:
  39876077
• Pubmed Central ID:
  PMC12101219
• Document Type:
  Text
• Funding:
  F32 HL168826/HL/NHLBI NIH HHSUnited States/ ; R01 OH011528/OH/NIOSH CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  1092-1102 (23 pdf pages)
• Volume:
  57
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/261726/cdc_261726_DS1.pdf
• File Type:
  [PDF - 2.38 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f05806dba337c0a97f49eeda2405011d86ba9c8d207d8935b2a5b575ddc4317b63f73113ba6491e2690bd9261d8803703051d56e4f2a3137083b9468a5b1d05b