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Showing 41 - 60 of 75 results

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Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model.

Wiley, Nicole G. ;

Lutz, Chelsea S. ;

Thomas, Michael M.
; etc...

February 2026 | Birth Defects Research, 2026, v. 118, no. 2

Transplacental transmission of cytomegalovirus (CMV) after primary maternal infection during the first trimester of pregnancy is associated with the most severe sequelae from congenital CMV (cCMV) infection. We estimated the prevalence of cCMV infection due to primary maternal CMV infection in the United States.We built a probabilistic risk assessm ...

Title : Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model. Personal Author(s) : Wiley, Nicole G.;Lutz, Chelsea S.;Thomas, Michael M.;Ortega Sanchez, Ismael R.;Lanzieri, Tatiana M.; Published Date : February 2026 Pages in Document : e70025 (17 pdf pages) Source : Birth Defects Research, 2026, v. 118, no. 2 DOI : https://doi.org/10.1002/bdr2.70025 Journal Title : Birth Defects Research
Wiley, N. G., Lutz, C. S., Thomas, M. M., Ortega Sanchez, I. R., & Lanzieri, T. M. (2026). Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model. Birth Defects Research, 118(2). https://doi.org/10.1002/bdr2.70025

Wiley, Nicole G., Chelsea S. Lutz, Michael M. Thomas, Ismael R. Ortega Sanchez, and Tatiana M. Lanzieri. "Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model." Birth Defects Research 118, no. 2 (2026). https://doi.org/10.1002/bdr2.70025.

Wiley, Nicole G., et al. "Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model." Birth Defects Research, vol. 118, no. 2, 2026. Stacks. https://doi.org/10.1002/bdr2.70025.
Export RIS Citation Information. TY - Journal Article AU - Wiley, Nicole G. AU - Lutz, Chelsea S. AU - Thomas, Michael M. AU - Ortega Sanchez, Ismael R. AU - Lanzieri, Tatiana M. AB - Transplacental transmission of cytomegalovirus (CMV) after primary maternal infection during the first trimester of pregnancy is associated with the most severe sequelae from congenital CMV (cCMV) infection. We estimated the prevalence of cCMV infection due to primary maternal CMV infection in the United States. AB - We built a probabilistic risk assessment model inputting 2022 national natality data, national CMV seroprevalence estimates among females 15-49 years, and published vertical transmission rates to estimate cCMV infection prevalence and distribution by maternal age group, parity, and trimester of infection during pregnancy. AB - The estimated prevalence of cCMV infection due to primary maternal infection was 3.4 (95% CI: 2.0-6.0) per 1000 live births, resulting in 12,310 infants with cCMV infection in 2022. cCMV prevalence was higher among infants born to females 15-19 and 20-29 years (4.7 and 4.2 per 1000, respectively) than those born to females 30-39 and 40-49 years (2.6 per 1000, both). cCMV prevalence was higher among infants of primipara than multipara females (4.0 vs. 3.0 per 1000). Most infants with cCMV infection were born to females 20-29 years, either primipara (29%) or multipara (27%), and females 30-39 years, multipara (24%). Approximately 3160 (26%) cCMV infections resulted from first-trimester maternal infection. AB - Assuming an overall cCMV prevalence of 4.4 per 1000 live births, 77% of cCMV infections in the United States may be attributable to primary maternal infections. Data on group-specific prevalence of cCMV infection following primary maternal infection will be useful to inform preventative strategies. AB - Author manuscript AN - cdc:260787 C4 - PMC13094298 DO - https://doi.org/10.1002/bdr2.70025 IS - 2 J2 - Birth Defects Research KW - Pregnancy KW - Cytomegalovirus KW - Adolescent KW - Cytomegalovirus Infections KW - Female KW - Infant, Newborn KW - Young Adult KW - Seroepidemiologic Studies KW - Pregnancy Complications, Infectious KW - Infectious Disease Transmission, Vertical KW - Risk Assessment KW - Prevalence KW - Humans KW - Middle Aged KW - Adult KW - congenital cytomegalovirus KW - primary infection KW - risk assessment KW - probabilistic model KW - Humans KW - Female KW - Cytomegalovirus Infections KW - Pregnancy KW - Adult KW - Prevalence KW - Adolescent KW - Risk Assessment KW - Pregnancy Complications, Infectious KW - Infectious Disease Transmission, Vertical KW - Young Adult KW - Infant, Newborn KW - Seroepidemiologic Studies KW - Middle Aged KW - Cytomegalovirus LA - eng PY - 2026 T2 - Birth Defects Research T2 - Birth Defects Research, 2026, v. 118, no. 2 TI - Estimating the Prevalence of Congenital Cytomegalovirus Infection Due to Primary Maternal Infection in the United States: a Probabilistic Risk Assessment Model. VL - 118 UR - https://stacks.cdc.gov/view/cdc/260787 ER -
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Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015.

Lu, Haidong ;

Olshan, Andrew F. ;

Serre, Marc L.
; etc...

March 2026 | Annals of Epidemiology, 2026, v. 115

Birth defects are a leading cause of infant mortality in the United States, but little is known about causes of many types of birth defects. Spatiotemporal disease mapping to identify high-prevalence areas is a potential strategy to narrow the search for potential environmental and other causes that aggregate over space and time. We described the s ...

Title : Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015. Personal Author(s) : Lu, Haidong;Olshan, Andrew F.;Serre, Marc L.;Anthony, Kurtis M.;Fry, Rebecca C.;Forestieri, Nina E.;Keil, Alexander P.; Published Date : March 2026 Pages in Document : 85-90 (13 pdf pages) Source : Annals of Epidemiology, 2026, v. 115 DOI : https://doi.org/10.1016/j.annepidem.2026.01.012 Journal Title : Annals of Epidemiology
Lu, H., Olshan, A. F., Serre, M. L., Anthony, K. M., Fry, R. C., Forestieri, N. E., & Keil, A. P. (2026). Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015. Annals of Epidemiology, 115. https://doi.org/10.1016/j.annepidem.2026.01.012

Lu, Haidong, Andrew F. Olshan, Marc L. Serre, Kurtis M. Anthony, Rebecca C. Fry, Nina E. Forestieri, and Alexander P. Keil. "Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015." Annals of Epidemiology 115 (2026). https://doi.org/10.1016/j.annepidem.2026.01.012.

Lu, Haidong, et al. "Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015." Annals of Epidemiology, vol. 115, 2026. Stacks. https://doi.org/10.1016/j.annepidem.2026.01.012.
Export RIS Citation Information. TY - Journal Article AU - Lu, Haidong AU - Olshan, Andrew F. AU - Serre, Marc L. AU - Anthony, Kurtis M. AU - Fry, Rebecca C. AU - Forestieri, Nina E. AU - Keil, Alexander P. AB - Birth defects are a leading cause of infant mortality in the United States, but little is known about causes of many types of birth defects. Spatiotemporal disease mapping to identify high-prevalence areas is a potential strategy to narrow the search for potential environmental and other causes that aggregate over space and time. We described the spatial and temporal trends of the prevalence of birth defects in North Carolina during 2003-2015, using data on live births obtained from the North Carolina Birth Defects Monitoring Program. By employing a Bayesian space-time Poisson model, we estimated spatial and temporal trends of non-chromosomal and chromosomal birth defects. During 2003-2015, 52,524 (3.3 %) of 1598,807 live births had at least one recorded birth defect. The prevalence of non-chromosomal birth defects decreased from 3.8 % in 2003-2.9 % in 2015. Spatial modeling suggested a large geographic variation in non-chromosomal birth defects at census-tract level, with the highest prevalence in southeastern North Carolina. The strong spatial heterogeneity revealed in this work allowed us to identify geographic areas with higher prevalence of non-chromosomal birth defects in North Carolina. This variation will help inform future research focused on epidemiologic studies of birth defects to identify etiologic factors. AB - Author manuscript AN - cdc:260779 C4 - PMC12912798 DO - https://doi.org/10.1016/j.annepidem.2026.01.012 J2 - Annals of Epidemiology KW - Female KW - Poisson Distribution KW - Bayes Theorem KW - Prevalence KW - Male KW - Geographic Mapping KW - Humans KW - Infant, Newborn KW - Epidemiological Monitoring KW - Live Birth KW - Spatio-Temporal Analysis KW - Congenital Abnormalities KW - birth defects KW - Bayesian disease mapping KW - spatiotemporal analysis KW - Humans KW - Male KW - Female KW - Infant, Newborn KW - Spatio-Temporal Analysis KW - Geographic Mapping KW - Prevalence KW - Congenital Abnormalities KW - Epidemiological Monitoring KW - Bayes Theorem KW - Poisson Distribution KW - Live Birth LA - eng PY - 2026 T2 - Annals of Epidemiology T2 - Annals of Epidemiology, 2026, v. 115 TI - Spatiotemporal Trends of Birth Defects in North Carolina, 2003-2015. VL - 115 UR - https://stacks.cdc.gov/view/cdc/260779 ER -
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Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis.

Lipscomb, Joseph ;

Kimmick, Gretchen G. ;

Wilson, J. Frank
; etc...

February 2026 | Cancer, 2026, v. 132, no. 4

Women diagnosed with triple-negative (ER-, PR-, HER2-) breast cancer (TNBC) have poor survival outcomes compared with other breast cancer subtypes. Yet there is little nonexperimental data on whether guideline-concordant therapy translates to better outcomes over time, or about factors associated with receipt of such guideline care. This study addr ...

Title : Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis. Personal Author(s) : Lipscomb, Joseph;Kimmick, Gretchen G.;Wilson, J. Frank;Currey, Adam;Switchenko, Jeffrey M.;Wu, Xiao-Cheng;Cress, Rosemary D.;Toumbacaris, Nicolas;Ward, Kevin C.;Wike, Jennifer M.; Published Date : February 2026 Pages in Document : e70267 (23 pdf pages) Source : Cancer, 2026, v. 132, no. 4 DOI : https://doi.org/10.1002/cncr.70267 Journal Title : Cancer
Lipscomb, J., Kimmick, G. G., Wilson, J. F., Currey, A., Switchenko, J. M., Wu, X. C., Cress, R. D., Toumbacaris, N., Ward, K. C., & Wike, J. M. (2026). Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis. Cancer, 132(4). https://doi.org/10.1002/cncr.70267

Lipscomb, Joseph, Gretchen G. Kimmick, J. Frank Wilson, Adam Currey, Jeffrey M. Switchenko, Xiao-Cheng Wu, Rosemary D. Cress, Nicolas Toumbacaris, Kevin C. Ward, and Jennifer M. Wike. "Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis." Cancer 132, no. 4 (2026). https://doi.org/10.1002/cncr.70267.

Lipscomb, Joseph, et al. "Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis." Cancer, vol. 132, no. 4, 2026. Stacks. https://doi.org/10.1002/cncr.70267.
Export RIS Citation Information. TY - Journal Article AU - Lipscomb, Joseph AU - Kimmick, Gretchen G. AU - Wilson, J. Frank AU - Currey, Adam AU - Switchenko, Jeffrey M. AU - Wu, Xiao-Cheng AU - Cress, Rosemary D. AU - Toumbacaris, Nicolas AU - Ward, Kevin C. AU - Wike, Jennifer M. AB - Women diagnosed with triple-negative (ER-, PR-, HER2-) breast cancer (TNBC) have poor survival outcomes compared with other breast cancer subtypes. Yet there is little nonexperimental data on whether guideline-concordant therapy translates to better outcomes over time, or about factors associated with receipt of such guideline care. This study addresses these issues. AB - Using data from the Centers for Disease Control and Prevention National Program of Cancer Registries (NPCR) augmented via medical records abstraction, the authors constructed a cohort of women diagnosed with invasive, nonmetastatic (stage I-III) TNBC in 2004 (N = 747) and followed through 2015. The date and primary cause of death were derived from the NPCR and the National Death Index. Standard-of-care treatment (as aligned with the study's timeframe) was defined as being guideline concordant (GC) for surgery, radiation therapy, and chemotherapy based on appropriate initiation, regimen, and completion. Through regression modeling, the authors examined predictors of being GC and the association of GC with 10-year survival outcomes. AB - Controlling for patient, tumor, and sociodemographic factors, patients whose management was GC had significantly better all-cause survival (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.45-0.77), breast cancer-specific survival (HR, 0.60; 95% CI, 0.42-0.86), and also better non-breast cancer survival (HR, 0.63; 95% CI, 0.40-1.00), compared with those whose management was Not GC. Treatment at a Commission on Cancer-accredited facility was a significant predictor of receiving GC care (odds ratio, 1.87; 95% CI, 1.34-2.59). AB - Building on this study's methodology and its findings about the effectiveness of long-standing approaches to TNBC management, additional population-based studies are urgently needed as new therapeutic approaches are being integrated into guidelines and clinical practice. AB - Author manuscript AN - cdc:260778 C4 - PMC12980793 DO - https://doi.org/10.1002/cncr.70267 IS - 4 J2 - Cancer KW - Triple Negative Breast Neoplasms KW - Female KW - Combined Modality Therapy KW - Guideline Adherence KW - Aged KW - Registries KW - Humans KW - Practice Guidelines as Topic KW - Middle Aged KW - Adult KW - triple-negative breast cancer KW - guideline-concordant care KW - survival outcomes KW - Humans KW - Female KW - Triple Negative Breast Neoplasms KW - Middle Aged KW - Aged KW - Adult KW - Guideline Adherence KW - Practice Guidelines as Topic KW - Registries KW - Combined Modality Therapy LA - eng PY - 2026 T2 - Cancer T2 - Cancer, 2026, v. 132, no. 4 TI - Receipt of Guideline-concordant Local and Chemotherapy-based Systemic Therapy For Patients With Triple-negative Breast Cancer: 10-year Survival Outcomes in a Multi-state Population-based Analysis. VL - 132 UR - https://stacks.cdc.gov/view/cdc/260778 ER -
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Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy.

He, Andrea ;

Neyaz, Tahereh ;

Bhandaru, Vinay
; etc...

June 2026 | Neuropediatrics, 2026, v. 57, no. 3

Extant studies have shown that individuals with Duchenne muscular dystrophy (DMD) with distalvariants have higher frequencies of co-occurring neurodevelopmental concerns, compared with those with proximalvariants. Whether the reported co-occurrences betweengenotype and neurodevelopmental concerns in DMD are generalizable is not known. We therefore ...

Title : Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy. Personal Author(s) : He, Andrea;Neyaz, Tahereh;Bhandaru, Vinay;Rice, Madeline;Street, Natalie;Mathews, Katherine;Venkatesh, Yedatore Swamy;Ciafaloni, Emma;Howard, James;Conway, Kristin M.;Thangarajh, Mathula; Corporate Authors(s) : and the MD STARnet Published Date : June 2026 Pages in Document : 193-199 (14 pdf pages) Source : Neuropediatrics, 2026, v. 57, no. 3 DOI : https://doi.org/10.1055/a-2818-7095 Journal Title : Neuropediatrics
He, A., Neyaz, T., Bhandaru, V., Rice, M., Street, N., Mathews, K., Venkatesh, Y. S., Ciafaloni, E., Howard, J., Conway, K. M., & Thangarajh, M. (2026). Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy. Neuropediatrics, 57(3). https://doi.org/10.1055/a-2818-7095

He, Andrea, Tahereh Neyaz, Vinay Bhandaru, Madeline Rice, Natalie Street, Katherine Mathews, and Yedatore Swamy Venkatesh, et al.. "Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy." Neuropediatrics 57, no. 3 (2026). https://doi.org/10.1055/a-2818-7095.

He, Andrea, et al. "Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy." Neuropediatrics, vol. 57, no. 3, 2026. Stacks. https://doi.org/10.1055/a-2818-7095.
Export RIS Citation Information. TY - Journal Article AU - He, Andrea AU - Neyaz, Tahereh AU - Bhandaru, Vinay AU - Rice, Madeline AU - Street, Natalie AU - Mathews, Katherine AU - Venkatesh, Yedatore Swamy AU - Ciafaloni, Emma AU - Howard, James AU - Conway, Kristin M. AU - Thangarajh, Mathula A2 - and the MD STARnet AB - Extant studies have shown that individuals with Duchenne muscular dystrophy (DMD) with distal AB - variants have higher frequencies of co-occurring neurodevelopmental concerns, compared with those with proximal AB - variants. Whether the reported co-occurrences between AB - genotype and neurodevelopmental concerns in DMD are generalizable is not known. We therefore investigated the association between AB - genotype and neurodevelopmental concerns in DMD using population-based surveillance data to improve the generalizability of knowledge and better inform clinical care. AB - The population-based Muscular Dystrophy Surveillance, Tracking and Research Network (MD STARnet) data were used to investigate the neurodevelopmental concerns as a function of AB - genotype in 325 individuals with DMD. Proximal AB - variants were defined as those located 5' to AB - exon 45, and distal AB - variants as those located 3' of and including AB - exon 45. Distal AB - variants were further sub-classified into those with very distal variants in AB - exons 63-79. Odds ratios and confidence intervals of speech/language delay, autism spectrum disorder, attention-deficit hyperactivity disorder, obsessive-compulsive disorder, cognitive dysfunction, intellectual disability, and global developmental delay between proximal AB - distal AB - variants were calculated. AB - The odds ratios were highest for global developmental delay (17.09), multiple neurodevelopmental concerns (8.0), and intellectual disability (6.95) in those with AB - variants in exons 63-79 compared with those with AB - variants in exons 45-62. There were no statistically significant associations between the presence of neurodevelopmental concerns and proximal AB - distal AB - variant location. AB - We did not find statistically significant associations between neurodevelopmental concerns and AB - variant locations in population-level data, except for those with very distal AB - mutations. The highest neurodevelopmental burden was among individuals with AB - variants located in exons 63-79. AB - Author manuscript AN - cdc:260770 C4 - PMC13081602 DO - https://doi.org/10.1055/a-2818-7095 IS - 3 J2 - Neuropediatrics KW - Neurodevelopmental Disorders KW - Adolescent KW - Child KW - Genotype KW - Female KW - Muscular Dystrophy, Duchenne KW - Male KW - Exons KW - Humans KW - Child, Preschool KW - Dystrophin KW - Duchenne muscular dystrophy KW - neurodevelopment KW - speech and language delay KW - attention-deficit hyperactivity disorder KW - MD STARnet KW - Humans KW - Muscular Dystrophy, Duchenne KW - Male KW - Dystrophin KW - Genotype KW - Neurodevelopmental Disorders KW - Child KW - Child, Preschool KW - Adolescent KW - Female KW - Exons LA - eng PY - 2026 T2 - Neuropediatrics T2 - Neuropediatrics, 2026, v. 57, no. 3 TI - Population-Based Investigation of DMD Genotype and Neurodevelopmental Concerns in Duchenne Muscular Dystrophy. VL - 57 UR - https://stacks.cdc.gov/view/cdc/260770 ER -
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Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis.

Conderino, Sarah ;

Kirchner, H. Lester ;

Thorpe, Lorna E.
; etc...

December 2025 | Journal of the American Medical Informatics Association: JAMIA, 2025, v. 33, no. 3

We discuss implications of potential ascertainment biases for studies examining diabetes risk following SARS-CoV-2 infection using electronic health records (EHRs). We quantitatively explore sensitivity of results to misclassification of COVID-19 status using data from the U.S.-based Diabetes in Children, Adolescents and Young Adults (DiCAYA) Netwo ...

Title : Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis. Personal Author(s) : Conderino, Sarah;Kirchner, H. Lester;Thorpe, Lorna E.;Divers, Jasmin;Hirsch, Annemarie G.;Nordberg, Cara M.;Schwartz, Brian S.;Zhang, Lu;Cai, Bo;Rudisill, Caroline;Obeid, Jihad S.;Liese, Angela;Allen, Katie S.;Dixon, Brian E.;Crume, Tessa;Dabelea, Dana;Burgett, Shawna;Bellatorre, Anna;Shao, Hui;Bian, Jiang;Guo, Yi;Bost, Sarah;Lyu, Tianchen;Reynolds, Kristi;Mefford, Matthew T.;Zhou, Hui;Zhou, Matt;Lustigova, Eva;Utidjian, Levon H.;Maltenfort, Mitchell;Kamboj, Manmohan;Mendonca, Eneida A.;Hanley, Patrick;Zaganjor, Ibrahim;Pavkov, Meda E.;Rosenman, Marc;Titus, Andrea R.; Published Date : December 2025 Pages in Document : 710-718 (17 pdf pages) Source : Journal of the American Medical Informatics Association: JAMIA, 2025, v. 33, no. 3 DOI : https://doi.org/10.1093/jamia/ocaf229 Journal Title : Journal of the American Medical Informatics Association: JAMIA
Conderino, S., Kirchner, H. L., Thorpe, L. E., Divers, J., Hirsch, A. G., Nordberg, C. M., Schwartz, B. S., Zhang, L., Cai, B., Rudisill, C., Obeid, J. S., Liese, A., Allen, K. S., Dixon, B. E., Crume, T., Dabelea, D., Burgett, S., Bellatorre, A., Shao, H., ... Titus, A. R. (2025). Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis. Journal of the American Medical Informatics Association: JAMIA, 33(3). https://doi.org/10.1093/jamia/ocaf229

Conderino, Sarah, H. Lester Kirchner, Lorna E. Thorpe, Jasmin Divers, Annemarie G. Hirsch, Cara M. Nordberg, and Brian S. Schwartz, et al.. "Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis." Journal of the American Medical Informatics Association: JAMIA 33, no. 3 (2025). https://doi.org/10.1093/jamia/ocaf229.

Conderino, Sarah, et al. "Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis." Journal of the American Medical Informatics Association: JAMIA, vol. 33, no. 3, 2025. Stacks. https://doi.org/10.1093/jamia/ocaf229.
Export RIS Citation Information. TY - Journal Article AU - Conderino, Sarah AU - Kirchner, H. Lester AU - Thorpe, Lorna E. AU - Divers, Jasmin AU - Hirsch, Annemarie G. AU - Nordberg, Cara M. AU - Schwartz, Brian S. AU - Zhang, Lu AU - Cai, Bo AU - Rudisill, Caroline AU - Obeid, Jihad S. AU - Liese, Angela AU - Allen, Katie S. AU - Dixon, Brian E. AU - Crume, Tessa AU - Dabelea, Dana AU - Burgett, Shawna AU - Bellatorre, Anna AU - Shao, Hui AU - Bian, Jiang AU - Guo, Yi AU - Bost, Sarah AU - Lyu, Tianchen AU - Reynolds, Kristi AU - Mefford, Matthew T. AU - Zhou, Hui AU - Zhou, Matt AU - Lustigova, Eva AU - Utidjian, Levon H. AU - Maltenfort, Mitchell AU - Kamboj, Manmohan AU - Mendonca, Eneida A. AU - Hanley, Patrick AU - Zaganjor, Ibrahim AU - Pavkov, Meda E. AU - Rosenman, Marc AU - Titus, Andrea R. AB - We discuss implications of potential ascertainment biases for studies examining diabetes risk following SARS-CoV-2 infection using electronic health records (EHRs). We quantitatively explore sensitivity of results to misclassification of COVID-19 status using data from the U.S.-based Diabetes in Children, Adolescents and Young Adults (DiCAYA) Network on children (≤17 years) and young adults (18-44 years). AB - In our retrospective case study from the DiCAYA Network, SARS-CoV-2 was identified using labs and diagnoses from June 1, 2020 to December 31, 2021. Patients were followed through December 31, 2022 for new diabetes diagnoses. Sites examined incident diabetes by COVID-19 status using Cox proportional hazards models. Results were pooled in meta-analyses. A bias analysis examined potential impact of COVID-19 misclassification scenarios on results, guided by hypotheses that sensitivity would be <50% and would be higher among those who developed diabetes. AB - Prevalence of documented COVID-19 was low overall and variable across sites (children: 4.4%-7.7%, young adults: 6.2%-22.7%). Individuals with documented COVID-19 were at higher risk of incident diabetes compared to those with no documented infection, but results were heterogeneous across sites. Findings were highly sensitive to COVID-19 misclassification assumptions. Observed results could be biased away from the null under several differential misclassification scenarios. AB - Although EHR-based documentation of COVID-19 was associated with incident diabetes, COVID-19 phenotypes likely had low sensitivity, with considerable variation across sites. Misclassification assumptions strongly impacted interpretation of results. AB - Given the potential for low phenotype sensitivity and misclassification, caution is warranted when interpreting analyses of COVID-19 and incident diabetes using clinical or administrative databases. AB - Author manuscript AN - cdc:260879 C4 - PMC12884381 DO - https://doi.org/10.1093/jamia/ocaf229 IS - 3 J2 - Journal of the American Medical Informatics Association: JAMIA KW - Adolescent KW - Female KW - Sensitivity and Specificity KW - Diabetes Mellitus KW - SARS-CoV-2 KW - Proportional Hazards Models KW - Electronic Health Records KW - Young Adult KW - COVID-19 KW - Retrospective Studies KW - Child KW - Incidence KW - Male KW - Humans KW - Adult KW - Phenotype KW - Diabetes mellitus KW - COVID-19 KW - SARS-CoV-2 KW - electronic health records KW - misclassification KW - Humans KW - Electronic Health Records KW - COVID-19 KW - Adult KW - Adolescent KW - Retrospective Studies KW - Young Adult KW - Child KW - Diabetes Mellitus KW - Phenotype KW - Proportional Hazards Models KW - Male KW - Female KW - Sensitivity and Specificity KW - SARS-CoV-2 KW - Incidence LA - eng PY - 2025 T2 - Journal of the American Medical Informatics Association: JAMIA T2 - Journal of the American Medical Informatics Association: JAMIA, 2025, v. 33, no. 3 TI - Multi-site Analysis of COVID-19 and New-onset Diabetes Reveals Need For Improved Sensitivity of EHR-based COVID-19 Phenotypes-a DiCAYA Network Analysis. VL - 33 UR - https://stacks.cdc.gov/view/cdc/260879 ER -
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The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools.

Laskowski, Larissa K. ;

Khezri, Mehrdad ;

Bennett, Alex S.
; etc...

March 2026 | Health Promotion Practice, 2026, v. 27, no. 2

There is an urgent need to ensure the opioid overdose reversal agent naloxone is available to protect youth given the increasing rates of overdose among this population. Through a public-academic partnership, overdose education and naloxone distribution training were provided to nonmedical public school staff in New York City. School staff were inv ...

Title : The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools. Personal Author(s) : Laskowski, Larissa K.;Khezri, Mehrdad;Bennett, Alex S.;Lee, Matthew;Walters, Suzan M.;Allen, Bennett;Bunting, Amanda M.; Published Date : March 2026 Pages in Document : 227-232 (10 pdf pages) Source : Health Promotion Practice, 2026, v. 27, no. 2 DOI : https://doi.org/10.1177/15248399251318695 Journal Title : Health Promotion Practice
Laskowski, L. K., Khezri, M., Bennett, A. S., Lee, M., Walters, S. M., Allen, B., & Bunting, A. M. (2026). The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools. Health Promotion Practice, 27(2). https://doi.org/10.1177/15248399251318695

Laskowski, Larissa K., Mehrdad Khezri, Alex S. Bennett, Matthew Lee, Suzan M. Walters, Bennett Allen, and Amanda M. Bunting. "The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools." Health Promotion Practice 27, no. 2 (2026). https://doi.org/10.1177/15248399251318695.

Laskowski, Larissa K., et al. "The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools." Health Promotion Practice, vol. 27, no. 2, 2026. Stacks. https://doi.org/10.1177/15248399251318695.
Export RIS Citation Information. TY - Journal Article AU - Laskowski, Larissa K. AU - Khezri, Mehrdad AU - Bennett, Alex S. AU - Lee, Matthew AU - Walters, Suzan M. AU - Allen, Bennett AU - Bunting, Amanda M. AB - There is an urgent need to ensure the opioid overdose reversal agent naloxone is available to protect youth given the increasing rates of overdose among this population. Through a public-academic partnership, overdose education and naloxone distribution training were provided to nonmedical public school staff in New York City. School staff were invited to a 90-minute in-person training. Consented participants took a pre- and post-survey to assess their overdose knowledge, confidence, and substance use stigma. A majority of respondents had never received training on how to identify an opioid overdose (70.7%) or how to administer naloxone (73.5%). Participants' overdose knowledge, including recognition of the signs of an overdose, response actions, and confidence to respond, significantly increased pre- to post-training. Participants' stigmatization of drug use significantly decreased following the training. Naloxone access and opioid overdose response training for nonmedical school staff is an acceptable and effective solution to expand overdose response. The significant reduction in participants' stigmatization of drug use suggests overdose education and naloxone training that address stigma may help prevent unnecessary mortality among youth. AB - Author manuscript AN - cdc:261679 C4 - PMC12353646 DO - https://doi.org/10.1177/15248399251318695 IS - 2 J2 - Health Promotion Practice KW - Adolescent KW - Schools KW - Health Education KW - Female KW - Health Knowledge, Attitudes, Practice KW - Social Stigma KW - Opiate Overdose KW - Narcotic Antagonists KW - Male KW - Humans KW - Drug Overdose KW - Adult KW - Naloxone KW - overdose KW - naloxone KW - school KW - youth KW - school policy KW - overdose education KW - training KW - Humans KW - Naloxone KW - Narcotic Antagonists KW - Drug Overdose KW - Male KW - Female KW - Health Education KW - Social Stigma KW - Schools KW - Health Knowledge, Attitudes, Practice KW - Adolescent KW - Adult KW - Opiate Overdose LA - eng PY - 2026 T2 - Health Promotion Practice T2 - Health Promotion Practice, 2026, v. 27, no. 2 TI - The Prevention Education Partnership: a Public-Academic Partnership to Expand Overdose Education and Naloxone Training in New York City Public Schools. VL - 27 UR - https://stacks.cdc.gov/view/cdc/261679 ER -
Coming Soon

Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas.

Zaman, Shaila ;

Villegas, Aedan C. ;

Shenoi, Rohit P.

March 2026 | Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention, March 2026

Natural language processing (NLP) can process unstructured text to provide information on injuries but has not been used for drowning. We tested the effectiveness of NLP in identifying risk and protective factors for drowning present in media and police reports.This was a cross-sectional study of persons of all ages who unintentionally drowned in m ...

Title : Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas. Personal Author(s) : Zaman, Shaila;Villegas, Aedan C.;Shenoi, Rohit P.; Published Date : March 2026 Pages in Document : ip-2025 (9 pdf pages) Source : Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention, March 2026 DOI : https://doi.org/10.1136/ip-2025-046010 Journal Title : Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention
Zaman, S., Villegas, A. C., & Shenoi, R. P. (2026). Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas. Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention. https://doi.org/10.1136/ip-2025-046010

Zaman, Shaila, Aedan C. Villegas, and Rohit P. Shenoi. "Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas." Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention (2026). https://doi.org/10.1136/ip-2025-046010.

Zaman, Shaila, et al. "Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas." Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention, 2026. Stacks. https://doi.org/10.1136/ip-2025-046010.
Export RIS Citation Information. TY - Journal Article AU - Zaman, Shaila AU - Villegas, Aedan C. AU - Shenoi, Rohit P. AB - Natural language processing (NLP) can process unstructured text to provide information on injuries but has not been used for drowning. We tested the effectiveness of NLP in identifying risk and protective factors for drowning present in media and police reports. AB - This was a cross-sectional study of persons of all ages who unintentionally drowned in metropolitan Houston, Texas between 2016 and 2022. Drowning incident data were obtained from media reports (NexisUni using keywords 'drown' and 'submersion' to access online media archives in print blog, video and audio record formats) and from redacted police reports. Temporal, demographic and incident narratives were obtained manually. Information on swimming ability, supervision, alcohol use and life jacket use was extracted from report narratives using OpenAI's GPT-4o models which converted unstructured narratives into analysable structured data. Extracted data were validated against manually reviewed ground truth data in 20% of the cases. NLP was assessed for accuracy, precision, recall and F1 score. AB - There were 190 reports of drowning (142 (74.7%) fatal and 48 (25.3%) non-fatal) between 2016 and 2022. The median age was 16 years (IQR: 5-41). Children aged 0-17 years constituted 45.8% of the cohort; 125 (65.8%) were males. Most drownings occurred in natural water (65.8%); the rest were in confined water (30.5%). The NLP metrics were recall (0.6-1.0), precision (0.7-1.00), F1-score (0.6-1.0) and accuracy (0.9-1.00). AB - NLP is a novel method of extracting information on drowning risk and protective factors from media report narratives. This can be used to study the epidemiology of drowning. AB - Author manuscript AN - cdc:260755 C4 - PMC13097479 DO - https://doi.org/10.1136/ip-2025-046010 J2 - Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention LA - eng PY - 2026 T2 - Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention T2 - Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention, March 2026 TI - Using Artificial Intelligence to Identify Drowning Risk and Protective Factors Present in Media Reports in Metropolitan Houston, Texas. UR - https://stacks.cdc.gov/view/cdc/260755 ER -
Coming Soon

Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024.

Rivera, Alexis V. ;

Rodriguez, Kristina ;

Shelton, Mimi
; etc...

March 2026 | AIDS and Behavior, March 2026

Women of transgender experience (WTE) have been disproportionately burdened by mpox. Using 2024 data from the New York City site of the National HIV Behavioral Surveillance study among WTE and transfeminine people (TFP), we identified factors associated with receiving at least one dose of the mpox vaccine. Of 103 WTE/TFP, most identified as Hispani ...

Title : Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024. Personal Author(s) : Rivera, Alexis V.;Rodriguez, Kristina;Shelton, Mimi;Edelstein, Zoe; Published Date : March 2026 Pages in Document : 9 pdf pages Source : AIDS and Behavior, March 2026 DOI : https://doi.org/10.1007/s10461-026-05090-w Journal Title : AIDS and Behavior
Rivera, A. V., Rodriguez, K., Shelton, M., & Edelstein, Z. (2026). Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024. AIDS and Behavior. https://doi.org/10.1007/s10461-026-05090-w

Rivera, Alexis V., Kristina Rodriguez, Mimi Shelton, and Zoe Edelstein. "Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024." AIDS and Behavior (2026). https://doi.org/10.1007/s10461-026-05090-w.

Rivera, Alexis V., et al. "Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024." AIDS and Behavior, 2026. Stacks. https://doi.org/10.1007/s10461-026-05090-w.
Export RIS Citation Information. TY - Journal Article AU - Rivera, Alexis V. AU - Rodriguez, Kristina AU - Shelton, Mimi AU - Edelstein, Zoe AB - Women of transgender experience (WTE) have been disproportionately burdened by mpox. Using 2024 data from the New York City site of the National HIV Behavioral Surveillance study among WTE and transfeminine people (TFP), we identified factors associated with receiving at least one dose of the mpox vaccine. Of 103 WTE/TFP, most identified as Hispanic/Latina and being born outside of the United States with 40% receiving at least one dose. Participants who self-reported having HIV were more than twice as likely to have received a dose (PR: 2.31; 95% CI: 1.20-4.47). Mpox vaccine outreach efforts may benefit from status-neutral strategies. AB - Author manuscript AN - cdc:260754 C4 - PMC13071804 DO - https://doi.org/10.1007/s10461-026-05090-w J2 - AIDS and Behavior KW - Mpox KW - women of transgender experience KW - vaccine KW - HIV LA - eng PY - 2026 T2 - AIDS and Behavior T2 - AIDS and Behavior, March 2026 TI - Factors Associated With Mpox Vaccination Uptake Among Women of Transgender Experience and Transfeminine People in New York City, 2024. UR - https://stacks.cdc.gov/view/cdc/260754 ER -
Coming Soon

Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020.

Jim, Melissa A. ;

Arias, Elizabeth ;

Haverkamp, Donald S.
; etc...

March 2026 | American Journal of Epidemiology, 2026, v. 195, no. 3

Racial misclassification on death certificates leads to inaccurate mortality data for American Indian and Alaska Native (AI/AN) populations. We describe methods for correcting for racial misclassification among non-Hispanic AI/AN (NH-AI/AN) populations using data from the year 2020. We linked National Death Index records with the Indian Health Serv ...

Title : Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020. Personal Author(s) : Jim, Melissa A.;Arias, Elizabeth;Haverkamp, Donald S.;Paisano, Roberta;Apostolou, Andria;Melkonian, Stephanie C.; Published Date : March 2026 Pages in Document : 736-747 (22 pdf pages) Source : American Journal of Epidemiology, 2026, v. 195, no. 3 DOI : https://doi.org/10.1093/aje/kwaf094 Journal Title : American Journal of Epidemiology
Jim, M. A., Arias, E., Haverkamp, D. S., Paisano, R., Apostolou, A., & Melkonian, S. C. (2026). Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020. American Journal of Epidemiology, 195(3). https://doi.org/10.1093/aje/kwaf094

Jim, Melissa A., Elizabeth Arias, Donald S. Haverkamp, Roberta Paisano, Andria Apostolou, and Stephanie C. Melkonian. "Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020." American Journal of Epidemiology 195, no. 3 (2026). https://doi.org/10.1093/aje/kwaf094.

Jim, Melissa A., et al. "Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020." American Journal of Epidemiology, vol. 195, no. 3, 2026. Stacks. https://doi.org/10.1093/aje/kwaf094.
Export RIS Citation Information. TY - Journal Article AU - Jim, Melissa A. AU - Arias, Elizabeth AU - Haverkamp, Donald S. AU - Paisano, Roberta AU - Apostolou, Andria AU - Melkonian, Stephanie C. AB - Racial misclassification on death certificates leads to inaccurate mortality data for American Indian and Alaska Native (AI/AN) populations. We describe methods for correcting for racial misclassification among non-Hispanic AI/AN (NH-AI/AN) populations using data from the year 2020. We linked National Death Index records with the Indian Health Service (IHS) patient registration database to identify AI/AN decedents. Matches were then linked to the National Vital Statistics System mortality data to identify AI/AN individuals who had been misclassified as another race on their death certificates. Analyses were limited to NH-AI/AN and purchased/referred care delivery areas or urban areas. We compared death rates and counts pre- and postlinkage and calculated sensitivity and classification ratios by region, sex, age, cause of death, and urban area. Racial misclassification on death certificates among NH-AI/AN varied by geographic region. Some of the highest racial misclassification occurred in the Southern Plains and Pacific Coast. Death rates for NH-AI/AN people and differences between NH-AI/AN and non-Hispanic White people were larger using the linked data. Improving AI/AN mortality data using linkages between vital statistics data and IHS strengthens data quality and can help address health disparities through public health planning efforts. AB - Author manuscript AN - cdc:261438 C4 - PMC12353377 DO - https://doi.org/10.1093/aje/kwaf094 IS - 3 J2 - American Journal of Epidemiology KW - Adolescent KW - Female KW - Vital Statistics KW - Quality Improvement KW - Aged KW - Infant, Newborn KW - Young Adult KW - Cause of Death KW - Mortality KW - United States Indian Health Service KW - Aged, 80 and over KW - Child KW - Death Certificates KW - Infant KW - Alaska Natives KW - Male KW - Middle Aged KW - Humans KW - Child, Preschool KW - Indians, North American KW - Adult KW - American Indian and Alaska Native KW - mortality KW - disparities KW - racial misclassification KW - data linkages KW - Humans KW - Alaska Natives KW - Death Certificates KW - Female KW - Male KW - Indians, North American KW - Middle Aged KW - Mortality KW - Adult KW - Aged KW - Cause of Death KW - Adolescent KW - Young Adult KW - Infant KW - United States Indian Health Service KW - Child, Preschool KW - Child KW - Quality Improvement KW - Aged, 80 and over KW - Vital Statistics KW - Infant, Newborn LA - eng PY - 2026 T2 - American Journal of Epidemiology T2 - American Journal of Epidemiology, 2026, v. 195, no. 3 TI - Improving Quality of Mortality Estimates Among Non-Hispanic American Indian and Alaska Native People, 2020. VL - 195 UR - https://stacks.cdc.gov/view/cdc/261438 ER -
Coming Soon

Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review.

Gibbs, Jenna L. ;

Vollmer, Brooke ;

Sheridan, Carolyn E.
; etc...

March 2026 | Journal of Occupational and Environmental Hygiene, 2026, v. 23, no. 3

The COVID-19 pandemic underscored the critical need for protective equipment, such as filtering facepiece respirators (FFRs), particularly for youth. This systematic review addresses the significant gap in evidence-based guidance for FFR use among US farm youth, a group potentially exposed to diverse respiratory hazards. Current FFR designs and pro ...

Title : Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review. Personal Author(s) : Gibbs, Jenna L.;Vollmer, Brooke;Sheridan, Carolyn E.;Pinkerton, Kent;Anthony, Renee T.;Holm, Stephanie;Karr, Catherine;Proctor, Anna;Swenson, Andrea; Published Date : March 2026 Pages in Document : 178-190 (21 pdf pages) Source : Journal of Occupational and Environmental Hygiene, 2026, v. 23, no. 3 DOI : https://doi.org/10.1080/15459624.2025.2589137 Journal Title : Journal of Occupational and Environmental Hygiene
Gibbs, J. L., Vollmer, B., Sheridan, C. E., Pinkerton, K., Anthony, R. T., Holm, S., Karr, C., Proctor, A., & Swenson, A. (2026). Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review. Journal of Occupational and Environmental Hygiene, 23(3). https://doi.org/10.1080/15459624.2025.2589137

Gibbs, Jenna L., Brooke Vollmer, Carolyn E. Sheridan, Kent Pinkerton, Renee T. Anthony, Stephanie Holm, Catherine Karr, Anna Proctor, and Andrea Swenson. "Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review." Journal of Occupational and Environmental Hygiene 23, no. 3 (2026). https://doi.org/10.1080/15459624.2025.2589137.

Gibbs, Jenna L., et al. "Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review." Journal of Occupational and Environmental Hygiene, vol. 23, no. 3, 2026. Stacks. https://doi.org/10.1080/15459624.2025.2589137.
Export RIS Citation Information. TY - Journal Article AU - Gibbs, Jenna L. AU - Vollmer, Brooke AU - Sheridan, Carolyn E. AU - Pinkerton, Kent AU - Anthony, Renee T. AU - Holm, Stephanie AU - Karr, Catherine AU - Proctor, Anna AU - Swenson, Andrea AB - The COVID-19 pandemic underscored the critical need for protective equipment, such as filtering facepiece respirators (FFRs), particularly for youth. This systematic review addresses the significant gap in evidence-based guidance for FFR use among US farm youth, a group potentially exposed to diverse respiratory hazards. Current FFR designs and protocols for FFR use are largely adult-centric. Adhering to PRISMA 2020 guidelines, a multidisciplinary panel reviewed 31 publications published between 1990 and 2023. An independent working group of agricultural safety professionals also contributed by reviewing procedures and publications to check for bias during the review process. Key findings show that while FFRs appear physiologically tolerable by youth study subjects. Subjective discomfort and poor fit of adult-sized respirators remain major barriers to effective use and compliance. Studies highlight the critical need for youth-specific FFR designs based on detailed facial anthropometrics and the development of standardized fit-testing protocols tailored for growing youth. Furthermore, evidence-based guidance on ethical pediatric medical evaluations for respirator use and targeted respiratory health education are urgently needed. This review emphasizes that a concerted effort from manufacturers, researchers, and regulatory bodies is essential to ensure youth on farms can safely use respiratory protection. AB - Author manuscript AN - cdc:260748 C4 - PMC13093579 DO - https://doi.org/10.1080/15459624.2025.2589137 IS - 3 J2 - Journal of Occupational and Environmental Hygiene KW - Occupational Exposure KW - Child KW - Adolescent KW - Farmers KW - Equipment Design KW - Respiratory Protective Devices KW - SARS-CoV-2 KW - Humans KW - COVID-19 KW - Agriculture KW - anthropometrics KW - FFR KW - N95 KW - pediatric KW - personal protective equipment (PPE) KW - Humans KW - Respiratory Protective Devices KW - COVID-19 KW - Adolescent KW - Occupational Exposure KW - Equipment Design KW - Farmers KW - Child KW - SARS-CoV-2 LA - eng PY - 2026 T2 - Journal of Occupational and Environmental Hygiene T2 - Journal of Occupational and Environmental Hygiene, 2026, v. 23, no. 3 TI - Filtering Facepiece Respirator Use Among Farm Youth in the US: a Review. VL - 23 UR - https://stacks.cdc.gov/view/cdc/260748 ER -
Coming Soon

Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment.

Geraghty, Eamon ;

Milkovich, Pamela J ;

Scott, Erika
; etc...

March 2026 | Journal of Agromedicine, March 2026

Cardiovascular disease (CVD) is the leading cause of death globally, and suitable interventions are needed for prevention. Certain occupations can create barriers to accessing healthcare while also being a driving force behind lifestyle behaviors that increase risk of CVD. This study analyzed the Framingham 10-year risk for developing coronary hear ...

Title : Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment. Personal Author(s) : Geraghty, Eamon;Milkovich, Pamela J;Scott, Erika;Roome, Mandy;Krupa, Nicole L;Jenkins, Paul L; Published Date : March 2026 Pages in Document : 1-9 (15 pdf pages) Source : Journal of Agromedicine, March 2026 DOI : https://doi.org/10.1080/1059924X.2026.2642972 Journal Title : Journal of Agromedicine
Geraghty, E., Milkovich, P. J., Scott, E., Roome, M., Krupa, N. L., & Jenkins, P. L. (2026). Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment. Journal of Agromedicine. https://doi.org/10.1080/1059924X.2026.2642972

Geraghty, Eamon, Pamela J Milkovich, Erika Scott, Mandy Roome, Nicole L Krupa, and Paul L Jenkins. "Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment." Journal of Agromedicine (2026). https://doi.org/10.1080/1059924X.2026.2642972.

Geraghty, Eamon, et al. "Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment." Journal of Agromedicine, 2026. Stacks. https://doi.org/10.1080/1059924X.2026.2642972.
Export RIS Citation Information. TY - Journal Article AU - Geraghty, Eamon AU - Milkovich, Pamela J AU - Scott, Erika AU - Roome, Mandy AU - Krupa, Nicole L AU - Jenkins, Paul L AB - Cardiovascular disease (CVD) is the leading cause of death globally, and suitable interventions are needed for prevention. Certain occupations can create barriers to accessing healthcare while also being a driving force behind lifestyle behaviors that increase risk of CVD. This study analyzed the Framingham 10-year risk for developing coronary heart disease (CHD), among Maine loggers and commercial fishermen residing in Maine, Massachusetts, Oregon, and Alaska compared to the general population of working adults. AB - Between 2019 and 2024, loggers and commercial fishermen engaged in health screenings via three studies. Self-reported data regarding health behaviors, as well as anthropometric and biomarker measures, were collected at each screening and were obtained from National Health and Nutrition Examination Survey (NHANES) for a sample of working adults. Women were excluded due to their limited representation in the logging and commercial fishing populations. Framingham Risk Scores (FRS) for Hard CHD were established for each population, and comparisons were made based on both overall risk and component risk factors. AB - This study included 44 loggers, 164 commercial fishermen, and 1073 working adults from the NHANES cohort. Commercial fishermen had the highest estimated 10-year FRS with an average of 6.95%, followed by the NHANES sample at 6.39% and loggers with 5.70%. AB - Though this study demonstrates loggers and commercial fishermen have a similar CVD risk profile to other working aged men, this risk for all three groups is higher than ideal. This study indicates a need to better understand risk among these populations, as well as how the occupational setting can be used for future intervention. AB - Author manuscript AN - cdc:260745 C4 - PMC13105213 DO - https://doi.org/10.1080/1059924X.2026.2642972 J2 - Journal of Agromedicine KW - Chronic disease KW - framingham risk score KW - occupational health LA - eng PY - 2026 T2 - Journal of Agromedicine T2 - Journal of Agromedicine, March 2026 TI - Cardiovascular Disease Among Loggers and Commercial Fishermen: a Preliminary Risk Assessment. UR - https://stacks.cdc.gov/view/cdc/260745 ER -
Coming Soon

Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024.

Kava, Christine M. ;

Julian, Anne K. ;

Vahratian, Anjel
; etc...

June 2026 | Annals of Epidemiology, 2026, v. 118

Germline genetic testing can identify people at high risk of hereditary cancers. Limited data exist on differences in receipt and knowledge of germline genetic testing for cancer predisposition (hereafter genetic testing for cancer).Data from the National Center for Health Statistics Rapid Surveys System collected between January-February 2024 were ...

Title : Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024. Personal Author(s) : Kava, Christine M.;Julian, Anne K.;Vahratian, Anjel;Fletcher, Michelle R.; Published Date : June 2026 Pages in Document : 110078 (20 pdf pages) Source : Annals of Epidemiology, 2026, v. 118 DOI : https://doi.org/10.1016/j.annepidem.2026.110078 Journal Title : Annals of Epidemiology
Kava, C. M., Julian, A. K., Vahratian, A., & Fletcher, M. R. (2026). Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024. Annals of Epidemiology, 118. https://doi.org/10.1016/j.annepidem.2026.110078

Kava, Christine M., Anne K. Julian, Anjel Vahratian, and Michelle R. Fletcher. "Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024." Annals of Epidemiology 118 (2026). https://doi.org/10.1016/j.annepidem.2026.110078.

Kava, Christine M., et al. "Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024." Annals of Epidemiology, vol. 118, 2026. Stacks. https://doi.org/10.1016/j.annepidem.2026.110078.
Export RIS Citation Information. TY - Journal Article AU - Kava, Christine M. AU - Julian, Anne K. AU - Vahratian, Anjel AU - Fletcher, Michelle R. AB - Germline genetic testing can identify people at high risk of hereditary cancers. Limited data exist on differences in receipt and knowledge of germline genetic testing for cancer predisposition (hereafter genetic testing for cancer). AB - Data from the National Center for Health Statistics Rapid Surveys System collected between January-February 2024 were analyzed to estimate prevalence of receipt, knowledge, and interest in genetic testing for cancer. AB - An estimated 8.4% of adults received genetic testing for cancer. Among adults who had not received genetic testing for cancer, 52.0% knew genetic tests can indicate high risk of getting cancer in the future, and 40.7% expressed interest in getting tested in the future. The most common reason for interest was knowing risk would make a difference in health care decisions (93.3%). Among adults who did not report interest in genetic testing for cancer, the most common reason for disinterest was no provider recommendation (54.2%). Differences in receipt, knowledge, and interest were observed by sociodemographic characteristics and health history. AB - This report provides national estimates that can inform strategies to increase genetic testing for cancer among high-risk populations, including efforts to reduce potential testing barriers. AB - Author manuscript AN - cdc:260737 C4 - PMC13087923 DO - https://doi.org/10.1016/j.annepidem.2026.110078 J2 - Annals of Epidemiology KW - Genetic Testing KW - Adolescent KW - Female KW - Health Knowledge, Attitudes, Practice KW - Neoplasms KW - Genetic Predisposition to Disease KW - Aged KW - Male KW - Middle Aged KW - Humans KW - Young Adult KW - Adult KW - genetic testing KW - neoplasms KW - epidemiologic studies KW - National Center for Health Statistics, U.S. KW - health knowledge, attitudes, practice KW - Humans KW - Genetic Testing KW - Neoplasms KW - Female KW - Adult KW - Male KW - Health Knowledge, Attitudes, Practice KW - Middle Aged KW - Genetic Predisposition to Disease KW - Aged KW - Young Adult KW - Adolescent LA - eng PY - 2026 T2 - Annals of Epidemiology T2 - Annals of Epidemiology, 2026, v. 118 TI - Receipt, Knowledge, and Interest in Genetic Testing For Cancer - National Center For Health Statistics Rapid Surveys System, United States, January-February 2024. VL - 118 UR - https://stacks.cdc.gov/view/cdc/260737 ER -
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Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers.

Tore, Grant D. ;

DeSantiago, Melissa ;

Stapleton, Heather M.
; etc...

May 2026 | International Journal of Hygiene and Environmental Health, 2026, v. 274

Polycyclic aromatic hydrocarbon (PAH) exposures from agricultural and household woodburning may adversely impact kidney health, but studies are limited in Latin America where these practices are prevalent. We aimed to characterize PAH exposures and examine their associations with kidney injury biomarkers among agricultural workers in Chile. Among 4 ...

Title : Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers. Personal Author(s) : Tore, Grant D.;DeSantiago, Melissa;Stapleton, Heather M.;Obeid, Wassim;Parikh, Chirag R.;Kuiper, Jordan R.;Valenzuela, Margarita;Ferreccio, Catterina;Fazen, Louis;Dickerson, Aisha S.;Sandra Cortés, A.;Quirós-Alcalá, Lesliam; Published Date : May 2026 Pages in Document : 114791 (31 pdf pages) Source : International Journal of Hygiene and Environmental Health, 2026, v. 274 DOI : https://doi.org/10.1016/j.ijheh.2026.114791 Journal Title : International Journal of Hygiene and Environmental Health
Tore, G. D., DeSantiago, M., Stapleton, H. M., Obeid, W., Parikh, C. R., Kuiper, J. R., Valenzuela, M., Ferreccio, C., Fazen, L., Dickerson, A. S., Sandra Cortés, A., & Quirós-Alcalá, L. (2026). Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers. International Journal of Hygiene and Environmental Health, 274. https://doi.org/10.1016/j.ijheh.2026.114791

Tore, Grant D., Melissa DeSantiago, Heather M. Stapleton, Wassim Obeid, Chirag R. Parikh, Jordan R. Kuiper, and Margarita Valenzuela, et al.. "Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers." International Journal of Hygiene and Environmental Health 274 (2026). https://doi.org/10.1016/j.ijheh.2026.114791.

Tore, Grant D., et al. "Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers." International Journal of Hygiene and Environmental Health, vol. 274, 2026. Stacks. https://doi.org/10.1016/j.ijheh.2026.114791.
Export RIS Citation Information. TY - Journal Article AU - Tore, Grant D. AU - DeSantiago, Melissa AU - Stapleton, Heather M. AU - Obeid, Wassim AU - Parikh, Chirag R. AU - Kuiper, Jordan R. AU - Valenzuela, Margarita AU - Ferreccio, Catterina AU - Fazen, Louis AU - Dickerson, Aisha S. AU - Sandra Cortés, A. AU - Quirós-Alcalá, Lesliam AB - Polycyclic aromatic hydrocarbon (PAH) exposures from agricultural and household woodburning may adversely impact kidney health, but studies are limited in Latin America where these practices are prevalent. We aimed to characterize PAH exposures and examine their associations with kidney injury biomarkers among agricultural workers in Chile. Among 43 male agricultural workers from the Maule Cohort, we quantified urinary concentrations of five kidney injury biomarkers (IL-18, KIM-1, MCP-1, NGAL, YKL-40) and nine hydroxy-PAHs. Additionally, we measured 23 parent PAHs in wristbands, worn 8-11 days. We estimated percent differences in kidney biomarker concentrations and odds ratios of subclinical kidney injury (defined by two or more kidney biomarkers in the highest tertile) per interquartile range increase in PAH exposure concentration. All urinary PAH and kidney biomarkers were frequently detected (>70%) as were 13 parent PAH compounds in wristbands. We observed consistent positive associations of urinary IL-18 with select PAH exposures. Specifically, higher urinary IL-18 concentrations were observed in association with higher urinary concentrations of 1-PHE (80.4%; 95%CI: 33.8%, 143.3%), 2&3-PHE (44.1%; 95%CI: 12.7%, 84.2%), and 4-PHE (48.8%; 95%CI: 12.9%, 96.1%). Similarly, IL-18 concentrations were positively associated with higher wristband concentrations of anthracene (46.7%; 95%CI: 9.7%, 96.2%), phenanthrene (32.3%; 95%CI: 5.5%, 65.9%), fluorene (56.9%; 95%CI: 10.2%, 123.3%), and pyrene (34.1%; 95%CI: 3.2%, 74.3%) and among participants with naphthalene detected in their wristbands (51.5%; 95%CI: 1.3%, 126.7%). Wristband concentrations of benzo[e]pyrene, benzo[a]pyrene, and chrysene were associated with higher odds of subclinical AKI but not decreased kidney function. Our findings suggest that select PAH exposures may be associated with kidney injury, addressing major knowledge gaps and informing future studies of kidney health in agricultural communities. AB - Author manuscript AN - cdc:260724 C4 - PMC13140096 DO - https://doi.org/10.1016/j.ijheh.2026.114791 J2 - International Journal of Hygiene and Environmental Health KW - Occupational Exposure KW - Polycyclic Aromatic Hydrocarbons KW - Biomarkers KW - Acute Kidney Injury KW - Farmers KW - Male KW - Middle Aged KW - Humans KW - Adult KW - polycyclic aromatic hydrocarbons KW - acute kidney injury KW - agricultural workers KW - silicone wristbands KW - urinary biomonitoring KW - Humans KW - Polycyclic Aromatic Hydrocarbons KW - Male KW - Biomarkers KW - Occupational Exposure KW - Acute Kidney Injury KW - Adult KW - Middle Aged KW - Farmers LA - eng PY - 2026 T2 - International Journal of Hygiene and Environmental Health T2 - International Journal of Hygiene and Environmental Health, 2026, v. 274 TI - Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Biomarkers of Acute Kidney Injury Among Chilean Agricultural Workers. VL - 274 UR - https://stacks.cdc.gov/view/cdc/260724 ER -
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Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial.

Patterson, Paul Daniel ;

Martin, Sarah E. ;

Weaver, Matthew D.
; etc...

March 2026 | Sleep Health, March 2026

To test the effectiveness of a mobile phone text message-based intervention to mitigate fatigue and improve indicators of sleep health in a nationally representative sample of emergency medical services clinician shift workers.We conducted a cluster-randomized trial of emergency medical services agencies in the United States. Agencies (clusters) we ...

Title : Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial. Personal Author(s) : Patterson, Paul Daniel;Martin, Sarah E.;Weaver, Matthew D.;Patterson, Charity G.;Smith, Clair N.;Parmanto, Bambang;Pulantara, I. Wayan;Weiss, Leonard S.;Tripp, Rickquel P.;Guyette, Francis X.;Buysse, Daniel J.; Published Date : March 2026 Pages in Document : S2352-7218(26)00022 (22 pdf pages) Source : Sleep Health, March 2026 DOI : https://doi.org/10.1016/j.sleh.2026.02.011 Journal Title : Sleep Health
Patterson, P. D., Martin, S. E., Weaver, M. D., Patterson, C. G., Smith, C. N., Parmanto, B., Pulantara, I. W., Weiss, L. S., Tripp, R. P., Guyette, F. X., & Buysse, D. J. (2026). Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial. Sleep Health. https://doi.org/10.1016/j.sleh.2026.02.011

Patterson, Paul Daniel, Sarah E. Martin, Matthew D. Weaver, Charity G. Patterson, Clair N. Smith, Bambang Parmanto, and I. Wayan Pulantara, et al.. "Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial." Sleep Health (2026). https://doi.org/10.1016/j.sleh.2026.02.011.

Patterson, Paul Daniel, et al. "Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial." Sleep Health, 2026. Stacks. https://doi.org/10.1016/j.sleh.2026.02.011.
Export RIS Citation Information. TY - Journal Article AU - Patterson, Paul Daniel AU - Martin, Sarah E. AU - Weaver, Matthew D. AU - Patterson, Charity G. AU - Smith, Clair N. AU - Parmanto, Bambang AU - Pulantara, I. Wayan AU - Weiss, Leonard S. AU - Tripp, Rickquel P. AU - Guyette, Francis X. AU - Buysse, Daniel J. AB - To test the effectiveness of a mobile phone text message-based intervention to mitigate fatigue and improve indicators of sleep health in a nationally representative sample of emergency medical services clinician shift workers. AB - We conducted a cluster-randomized trial of emergency medical services agencies in the United States. Agencies (clusters) were randomized to intervention or the attention control group. Individual emergency medical services clinician shift workers used a mobile app to complete monthly surveys for 6 months and answered text message queries 1 out of every 4 weeks. Intervention text messages promoted adoption of fatigue mitigation behaviors. All attention control group text messages focused on teamwork improvement. AB - In total, 108 emergency medical services agencies and 708 emergency medical services shift workers were enrolled. Participants responded to >77% of monthly surveys and text message queries. The proportion of emergency medical services shift workers reporting severe fatigue declined over the study period; however, differences by intervention and attention control group status were not statistically significant. The proportion of participants with a clinically meaningful reduction in daytime sleepiness at 6 months was greater in the intervention group vs. the attention control group (p = .04). AB - Mobile phone text message-based assessments followed by immediate intervention are engaging, scalable on a nationwide level, and effective for addressing some indicators of sleep health like daytime sleepiness. Interventions combining behavioral sleep recommendations with fatigue mitigation strategies could result in larger effects on sleep health and fatigue. AB - ClinicalTrials.gov ID# NCT04456764 registered on June 29, 2020. First enrollment/consent on December 8, 2020. AB - Author manuscript AN - cdc:260723 C4 - PMC13078397 DO - https://doi.org/10.1016/j.sleh.2026.02.011 J2 - Sleep Health KW - Fatigue KW - Sleep KW - Shift work KW - Emergency medical services KW - Mobile phone KW - Text message LA - eng PY - 2026 T2 - Sleep Health T2 - Sleep Health, March 2026 TI - Real-time Text Message Intervention to Mitigate Workplace Fatigue in Emergency Medical Services: a Cluster-randomized Trial. UR - https://stacks.cdc.gov/view/cdc/260723 ER -
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Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia.

Hasan, Alvira Z. ;

Dombola, Aliness M. ;

Prosperi, Christine
; etc...

April 2026 | Vaccine, 2026, v. 79

Measles supplementary immunization activities (SIAs) help close immunity gaps but are resource-intensive and may not effectively reach school-aged children who miss routine vaccination. School-based vaccination screening may offer a complementary platform, yet evidence from low- and middle-income countries (LMICs) is limited. This study evaluated t ...

Title : Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia. Personal Author(s) : Hasan, Alvira Z.;Dombola, Aliness M.;Prosperi, Christine;Mufwambi, Webster;Sakala, Rodgers;Kapungu, Kelvin;Chongwe, Gershom;Singh, Prachi;Wang, Qiulin;Siputuma, Kennedy;Luulu, Maybin;Muchengwa, Malalu Mulundika;Sakala, Constance;Kamiji, Elicah;Bobo, Patricia;Sakala, Jacob;Matanda, Kennedy;Mwansa, Francis D.;Ward, Kirsten;Winter, Amy K.;Carcelen, Andrea C.;Truelove, Shaun A.;Moss, William J.;Mutembo, Simon; Published Date : April 2026 Pages in Document : 128453 (20 pdf pages) Source : Vaccine, 2026, v. 79 DOI : https://doi.org/10.1016/j.vaccine.2026.128453 Journal Title : Vaccine
Hasan, A. Z., Dombola, A. M., Prosperi, C., Mufwambi, W., Sakala, R., Kapungu, K., Chongwe, G., Singh, P., Wang, Q., Siputuma, K., Luulu, M., Muchengwa, M. M., Sakala, C., Kamiji, E., Bobo, P., Sakala, J., Matanda, K., Mwansa, F. D., Ward, K., ... Mutembo, S. (2026). Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia. Vaccine, 79. https://doi.org/10.1016/j.vaccine.2026.128453

Hasan, Alvira Z., Aliness M. Dombola, Christine Prosperi, Webster Mufwambi, Rodgers Sakala, Kelvin Kapungu, and Gershom Chongwe, et al.. "Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia." Vaccine 79 (2026). https://doi.org/10.1016/j.vaccine.2026.128453.

Hasan, Alvira Z., et al. "Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia." Vaccine, vol. 79, 2026. Stacks. https://doi.org/10.1016/j.vaccine.2026.128453.
Export RIS Citation Information. TY - Journal Article AU - Hasan, Alvira Z. AU - Dombola, Aliness M. AU - Prosperi, Christine AU - Mufwambi, Webster AU - Sakala, Rodgers AU - Kapungu, Kelvin AU - Chongwe, Gershom AU - Singh, Prachi AU - Wang, Qiulin AU - Siputuma, Kennedy AU - Luulu, Maybin AU - Muchengwa, Malalu Mulundika AU - Sakala, Constance AU - Kamiji, Elicah AU - Bobo, Patricia AU - Sakala, Jacob AU - Matanda, Kennedy AU - Mwansa, Francis D. AU - Ward, Kirsten AU - Winter, Amy K. AU - Carcelen, Andrea C. AU - Truelove, Shaun A. AU - Moss, William J. AU - Mutembo, Simon AB - Measles supplementary immunization activities (SIAs) help close immunity gaps but are resource-intensive and may not effectively reach school-aged children who miss routine vaccination. School-based vaccination screening may offer a complementary platform, yet evidence from low- and middle-income countries (LMICs) is limited. This study evaluated the feasibility and effectiveness of school-based vaccination screening and catch-up vaccination in Zambia. AB - A pilot intervention was conducted in 10 public and community primary schools in two urban districts (Ndola and Lusaka). Grade 1 learners were screened for routine vaccination status using under-5 cards or caregiver recall. Learners missing doses of oral poliovirus vaccine (OPV), diphtheria-tetanus-pertussis vaccine (DTP), or measles-containing vaccine (MCV) were referred for catch-up vaccination at health facilities or through school-based outreach. Descriptive and regression analyses assessed coverage, under-vaccination, catch-up uptake, and associated factors. AB - Of 1839 learners screened (98% participation), 38.0% were under-vaccinated and 1.8% were zero-dose. MCV2 coverage was lowest (65.6%) and declined with age. Among 699 under-vaccinated learners, 68.7% received at least one catch-up dose, mostly through school-based activities. Under-vaccination was associated with older age, accompaniment by a non-biological respondent, and low maternal education. Missed catch-up vaccination was associated with longer travel time, lack of an under-5 card, and caregiver unwillingness to accept school vaccination. Post-catch-up coverage increased to 96.6% for MCV1 and 83.5% for MCV2. AB - School-based vaccination screening was feasible, well-accepted, and substantially improved measles vaccination coverage. Scale-up should emphasize timely catch-up delivery, improved record-keeping and coordinated school-health planning. Future operational studies must assess the use of Early Childhood Learning (ECL) classes to reach children at younger ages. AB - Author manuscript AN - cdc:260716 C4 - PMC13137932 DO - https://doi.org/10.1016/j.vaccine.2026.128453 J2 - Vaccine KW - Schools KW - Female KW - Vaccination KW - Immunization Programs KW - Vaccination Coverage KW - Poliovirus Vaccine, Oral KW - Child KW - School Health Services KW - Students KW - Pilot Projects KW - Male KW - Humans KW - Measles Vaccine KW - Diphtheria-Tetanus-Pertussis Vaccine KW - Humans KW - Female KW - Male KW - Child KW - Vaccination KW - Schools KW - Immunization Programs KW - Measles Vaccine KW - Vaccination Coverage KW - Students KW - Poliovirus Vaccine, Oral KW - Diphtheria-Tetanus-Pertussis Vaccine KW - School Health Services KW - Pilot Projects LA - eng PY - 2026 T2 - Vaccine T2 - Vaccine, 2026, v. 79 TI - Assessing the Effectiveness of School-based Vaccination Checks to Identify and Reach un - and Under-vaccinated Students in Zambia. VL - 79 UR - https://stacks.cdc.gov/view/cdc/260716 ER -
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Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020.

Corry, Daniel T ;

Mercer Kollar, Laura M ;

Betz, Carter J
; etc...

March 2026 | Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention, 2026, v. 32, no. 2

Missing and Murdered Indigenous People is a historic and contemporary issue that has gained national attention. In 2021, homicide was the eighth leading cause of death among American Indian/Alaska Native (AIAN) persons aged between 1 and 54 years old, and homicide is the sixth leading cause of death among all AIAN males aged 1-54 years old.These da ...

Title : Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020. Personal Author(s) : Corry, Daniel T;Mercer Kollar, Laura M;Betz, Carter J;Fowler, Katherine A;Kearns, Megan C;Smith, Sharon G;Satter, Delight E; Published Date : March 2026 Pages in Document : 257-264 (18 pdf pages) Source : Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention, 2026, v. 32, no. 2 DOI : https://doi.org/10.1136/ip-2024-045335 Journal Title : Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
Corry, D. T., Mercer Kollar, L. M., Betz, C. J., Fowler, K. A., Kearns, M. C., Smith, S. G., & Satter, D. E. (2026). Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020. Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention, 32(2). https://doi.org/10.1136/ip-2024-045335

Corry, Daniel T, Laura M Mercer Kollar, Carter J Betz, Katherine A Fowler, Megan C Kearns, Sharon G Smith, and Delight E Satter. "Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020." Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention 32, no. 2 (2026). https://doi.org/10.1136/ip-2024-045335.

Corry, Daniel T, et al. "Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020." Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention, vol. 32, no. 2, 2026. Stacks. https://doi.org/10.1136/ip-2024-045335.
Export RIS Citation Information. TY - Journal Article AU - Corry, Daniel T AU - Mercer Kollar, Laura M AU - Betz, Carter J AU - Fowler, Katherine A AU - Kearns, Megan C AU - Smith, Sharon G AU - Satter, Delight E AB - Missing and Murdered Indigenous People is a historic and contemporary issue that has gained national attention. In 2021, homicide was the eighth leading cause of death among American Indian/Alaska Native (AIAN) persons aged between 1 and 54 years old, and homicide is the sixth leading cause of death among all AIAN males aged 1-54 years old. AB - These data will build knowledge around AIAN homicides and to identify circumstances that can aid in comprehensive Missing and Murdered Indigenous People prevention efforts. AB - AIAN homicide data came from Centers for Disease Control and Prevention's National Violent Death Reporting System, a state/jurisdiction-based surveillance system that collects detailed information about characteristics and circumstances of violent deaths. We examined data from 2003 to 2020 (all available years) from participating states/jurisdictions. We also assessed sociodemographic characteristics of victims and suspects, incident characteristics and differences across dichotomised urban/rural status. The study was conducted in 2022. AB - The National Violent Death Reporting System provided data on 2959 AIAN homicides from 2003 to 2020 (54.2% urban and 45.8% rural). Significant differences based on the two locations included type of weapon used, the location of the injury, race of the primary suspect, the victim's relationship to the suspect and select circumstances precipitating the homicide including crimes precipitating the homicide and homicides stemming from intimate partner violence. AB - These findings provide crucial information to strengthen public health efforts for prevention. AB - Author manuscript AN - cdc:262071 C4 - PMC11762353 DO - https://doi.org/10.1136/ip-2024-045335 IS - 2 J2 - Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention KW - Adolescent KW - Female KW - Young Adult KW - Cause of Death KW - Child KW - Violence KW - Infant KW - Homicide KW - Urban Population KW - Alaska Natives KW - Male KW - Middle Aged KW - Humans KW - Child, Preschool KW - Adult KW - Rural Population KW - Humans KW - Homicide KW - Male KW - Adult KW - Adolescent KW - Middle Aged KW - Child KW - Rural Population KW - Child, Preschool KW - Young Adult KW - Urban Population KW - Alaska Natives KW - Female KW - Infant KW - Cause of Death KW - Violence LA - eng PY - 2026 T2 - Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention T2 - Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention, 2026, v. 32, no. 2 TI - Homicides of American Indians/Alaska Natives in Urban Versus Rural Areas: United States National Violent Death Reporting System, 2003-2020. VL - 32 UR - https://stacks.cdc.gov/view/cdc/262071 ER -
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Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups.

Zhang, Zitong ;

Estépar, Raúl San José ;

Doucette, John T.
; etc...

May 2026 | Respiratory Medicine, 2026, v. 256

We have demonstrated diverging FEVtrajectories in WTC workers on longitudinal health surveillance. We performed a cohort study to investigate the association of those FEVtrajectories with novel QCT markers of subtle lung parenchymal injury.We included WTC responders with CT scans with quantitative measurements (all as percentage of the CT-measured ...

Title : Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups. Personal Author(s) : Zhang, Zitong;Estépar, Raúl San José;Doucette, John T.;Weber, Jonathan;Ross, James C.;Celedón, Juan C.;de la Hoz, Rafael E.; Published Date : May 2026 Pages in Document : 108810 (15 pdf pages) Source : Respiratory Medicine, 2026, v. 256 DOI : https://doi.org/10.1016/j.rmed.2026.108810 Journal Title : Respiratory Medicine
Zhang, Z., Estépar, R. S. J., Doucette, J. T., Weber, J., Ross, J. C., Celedón, J. C., & de la Hoz, R. E. (2026). Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups. Respiratory Medicine, 256. https://doi.org/10.1016/j.rmed.2026.108810

Zhang, Zitong, Raúl San José Estépar, John T. Doucette, Jonathan Weber, James C. Ross, Juan C. Celedón, and Rafael E. de la Hoz. "Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups." Respiratory Medicine 256 (2026). https://doi.org/10.1016/j.rmed.2026.108810.

Zhang, Zitong, et al. "Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups." Respiratory Medicine, vol. 256, 2026. Stacks. https://doi.org/10.1016/j.rmed.2026.108810.
Export RIS Citation Information. TY - Journal Article AU - Zhang, Zitong AU - Estépar, Raúl San José AU - Doucette, John T. AU - Weber, Jonathan AU - Ross, James C. AU - Celedón, Juan C. AU - de la Hoz, Rafael E. AB - We have demonstrated diverging FEV AB - trajectories in WTC workers on longitudinal health surveillance. We performed a cohort study to investigate the association of those FEV AB - trajectories with novel QCT markers of subtle lung parenchymal injury. AB - We included WTC responders with CT scans with quantitative measurements (all as percentage of the CT-measured lung volume) of five different metrics: normal parenchyma (Norm%), high attenuation normal parenchyma (NormHA%), interstitial lung abnormality features (ILAV%), honeycombing pattern (HcV%), and emphysema. We used linear regression to calculate each subject's FEV AB - slope and classified them into three distinct trajectories: 1) accelerated decline (ACCEL): < -62.5 mL/year; 2) normal decline (NORM): 0 to -30 ml/year, baseline FEV AB - %predicted>70% and no significant dyspnea; 3) improved: >0 mL/year. AB - Among 446 participants, 211 had ACCEL, 142 NORM, and 93 improved FEV AB - trajectory. On chest CTs at an average of 7.5 years after 11-September-2001 and compared to the NORM subgroup, ACCEL and improved trajectory subgroups both had less normal lung tissue (Norm%), with ACCEL having more emphysema, and improved participants higher ILAV% and NormHA%. The values of HcV% were very low and not significantly different across groups. ACCEL had a significantly higher all-cause mortality. AB - In this occupational cohort on longitudinal surveillance, accelerated lung function decline appears primarily associated with emphysema and airway disease, while lung function improvement is associated with subtle quantitative CT findings suggestive of interstitial inflammatory processes. The latter appeared largely nonprogressive at the time, as honeycombing was very infrequent and not different across trajectory subgroups. AB - Author manuscript AN - cdc:260699 C4 - PMC13267944 DO - https://doi.org/10.1016/j.rmed.2026.108810 J2 - Respiratory Medicine KW - Occupational Exposure KW - Longitudinal Studies KW - Female KW - Forced Expiratory Volume KW - Pulmonary Emphysema KW - Occupational Diseases KW - Cohort Studies KW - Male KW - Lung KW - Humans KW - Middle Aged KW - September 11 Terrorist Attacks KW - Adult KW - Tomography, X-Ray Computed KW - Occupational medicine KW - Occupational health KW - Inhalation injury KW - Chronic obstructive pulmonary disease KW - Spirometry KW - Cohort study KW - Interstitial lung disease KW - World Trade Center attack KW - 2001 KW - Humans KW - Tomography, X-Ray Computed KW - Male KW - Middle Aged KW - Forced Expiratory Volume KW - Longitudinal Studies KW - September 11 Terrorist Attacks KW - Female KW - Adult KW - Pulmonary Emphysema KW - Occupational Diseases KW - Occupational Exposure KW - Lung KW - Cohort Studies LA - eng PY - 2026 T2 - Respiratory Medicine T2 - Respiratory Medicine, 2026, v. 256 TI - Quantitative ct Metrics of Injury Patterns Among WTC Workers on Different Longitudinal FEV Trajectory Groups. VL - 256 UR - https://stacks.cdc.gov/view/cdc/260699 ER -
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Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications.

Bowman, Brett A. ;

Goldy, Devon W. ;

Roberson, Blake J.
; etc...

May 2026 | Chemical Research in Toxicology, 2026, v. 39, no. 5

Urinary phenyl mercapturic acid (PhMA) is a specific biomarker of benzene exposure that has been widely used in biomonitoring of the general population and in occupational exposure studies. However, previous research has identified significant interlaboratory variation in urinary PhMA concentrations due to differences in the acidity of the sample t ...

Title : Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications. Personal Author(s) : Bowman, Brett A.;Goldy, Devon W.;Roberson, Blake J.;Woodruff, Carmen A.;Blount, Benjamin C.;Chambers, David M.;Bhandari, Deepak; Published Date : May 2026 Pages in Document : 957-965 (19 pdf pages) Source : Chemical Research in Toxicology, 2026, v. 39, no. 5 DOI : https://doi.org/10.1021/acs.chemrestox.6c00075 Journal Title : Chemical Research in Toxicology
Bowman, B. A., Goldy, D. W., Roberson, B. J., Woodruff, C. A., Blount, B. C., Chambers, D. M., & Bhandari, D. (2026). Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications. Chemical Research in Toxicology, 39(5). https://doi.org/10.1021/acs.chemrestox.6c00075

Bowman, Brett A., Devon W. Goldy, Blake J. Roberson, Carmen A. Woodruff, Benjamin C. Blount, David M. Chambers, and Deepak Bhandari. "Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications." Chemical Research in Toxicology 39, no. 5 (2026). https://doi.org/10.1021/acs.chemrestox.6c00075.

Bowman, Brett A., et al. "Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications." Chemical Research in Toxicology, vol. 39, no. 5, 2026. Stacks. https://doi.org/10.1021/acs.chemrestox.6c00075.
Export RIS Citation Information. TY - Journal Article AU - Bowman, Brett A. AU - Goldy, Devon W. AU - Roberson, Blake J. AU - Woodruff, Carmen A. AU - Blount, Benjamin C. AU - Chambers, David M. AU - Bhandari, Deepak AB - Urinary phenyl mercapturic acid (PhMA) is a specific biomarker of benzene exposure that has been widely used in biomonitoring of the general population and in occupational exposure studies. However, previous research has identified significant interlaboratory variation in urinary PhMA concentrations due to differences in the acidity of the sample treatment conditions. This variation arises from the need to convert the benzene's precursor metabolite 6-hydroxy-2,4-cyclohexadienyl mercapturic acid (pre-PhMA) to PhMA. In this study, we systematically examined the influence of sample treatment pH on this reaction across various acidic treatment conditions representative of the reported PhMA assays. The resulting pre-PhMA and PhMA levels were quantified using an established liquid chromatography-tandem mass spectrometry assay. PhMA levels increased with more acidic treatment conditions until pH -0.6 when PhMA formation was the greatest at 53.1% formation of the total pre-PhMA. The formation of PhMA was dependent on sample treatment pH. Thus, a quadratic regression was modeled on PhMA formation vs pH across all acid types. The resulting regression model ( AB - = 0.874 × pH AB - - 12.146 × pH + 41.99, AB - = 0.978) can be used to determine the extent of PhMA formation for a specific treatment pH, improving the ability to compare PhMA results among studies with different analytical methods or to absolute health-based cutoffs such as the biological exposure index. To explain the incomplete PhMA formation, we utilized gas chromatography-mass spectrometry to identify and quantify the formation of benzene as a major byproduct of the acid-derived dehydration of pre-PhMA. Further, base-derived dehydration of pre-PhMA to PhMA was performed to validate the benzene formation mechanism observed with acid dehydration. AB - Author manuscript AN - cdc:260691 C4 - PMC13170563 DO - https://doi.org/10.1021/acs.chemrestox.6c00075 IS - 5 J2 - Chemical Research in Toxicology KW - Biomarkers KW - Biological Monitoring KW - Tandem Mass Spectrometry KW - Humans KW - Hydrogen-Ion Concentration KW - Benzene KW - Acetylcysteine KW - Humans KW - Benzene KW - Biomarkers KW - Biological Monitoring KW - Acetylcysteine KW - Hydrogen-Ion Concentration KW - Tandem Mass Spectrometry LA - eng PY - 2026 T2 - Chemical Research in Toxicology T2 - Chemical Research in Toxicology, 2026, v. 39, no. 5 TI - Characterizing the Conversion of Benzene Exposure Urinary Biomarker 6-Hydroxy-2,4-cyclohexadienyl Mercapturic Acid (Pre-PhMA) to Phenyl Mercapturic Acid (PhMA) For Human Biomonitoring Applications. VL - 39 UR - https://stacks.cdc.gov/view/cdc/260691 ER -
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Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024.

Miko, Shanna ;

Austin, Connie ;

Smith, Barbara L.
; etc...

April 2026 | The Journal of Infectious Diseases, April 2026

Zoonotic transmission of Cryptosporidium parvum (C. parvum) is often associated with ruminants. We report an investigation of cryptosporidiosis among persons who had contact with raccoons. In July 2024, two states identified 18 human cryptosporidiosis cases who volunteered at the same animal facility. One human specimen and two raccoon specimens te ...

Title : Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024. Personal Author(s) : Miko, Shanna;Austin, Connie;Smith, Barbara L.;Morrison, Shatavia S.;O'Connell, Brooke;Kunz, Jasen M.; Published Date : April 2026 Pages in Document : jiag212(8 pdf pages) Source : The Journal of Infectious Diseases, April 2026 DOI : https://doi.org/10.1093/infdis/jiag212 Journal Title : The Journal of Infectious Diseases
Miko, S., Austin, C., Smith, B. L., Morrison, S. S., O'Connell, B., & Kunz, J. M. (2026). Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiag212

Miko, Shanna, Connie Austin, Barbara L. Smith, Shatavia S. Morrison, Brooke O'Connell, and Jasen M. Kunz. "Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024." The Journal of Infectious Diseases (2026). https://doi.org/10.1093/infdis/jiag212.

Miko, Shanna, et al. "Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024." The Journal of Infectious Diseases, 2026. Stacks. https://doi.org/10.1093/infdis/jiag212.
Export RIS Citation Information. TY - Journal Article AU - Miko, Shanna AU - Austin, Connie AU - Smith, Barbara L. AU - Morrison, Shatavia S. AU - O'Connell, Brooke AU - Kunz, Jasen M. AB - Zoonotic transmission of Cryptosporidium parvum (C. parvum) is often associated with ruminants. We report an investigation of cryptosporidiosis among persons who had contact with raccoons. In July 2024, two states identified 18 human cryptosporidiosis cases who volunteered at the same animal facility. One human specimen and two raccoon specimens tested positive for C. parvum. Molecular subtyping of the C. parvum (subtype IIaA15G2R1) suggested zoonotic transmission between raccoons, humans, or their shared environments. These findings can inform public health actions, developed in collaboration with specific populations (e.g., wildlife rehabilitation facilities) and include interventions tailored to such settings to mitigate future outbreaks. AB - Author manuscript AN - cdc:260686 C4 - PMC13367001 DO - https://doi.org/10.1093/infdis/jiag212 J2 - The Journal of Infectious Diseases KW - Cryptosporidium parvum KW - outbreak KW - raccoons KW - wildlife KW - wildlife rehabilitation LA - eng PY - 2026 T2 - The Journal of Infectious Diseases T2 - The Journal of Infectious Diseases, April 2026 TI - Cryptosporidium Parvum Outbreak Among Volunteers of a Licensed Wildlife Rehabilitation Center Housing Raccoons-2024. UR - https://stacks.cdc.gov/view/cdc/260686 ER -
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Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function.

Osman, Sarah H. ;

Haynes, Christopher A. ;

Woolfitt, Adrian R.
; etc...

May 2026 | ACS Infectious Diseases, 2026, v. 12, no. 5

The SARS-CoV-2 spike protein is heavily glycosylated. These post-translational modifications aid in interactions with human angiotensin-converting enzyme 2 (hACE2), assist in antibody evasion, and help facilitate protein dynamics. However, the exact role glycans play in maintaining the protein structure and conformation is not fully understood. In ...

Title : Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function. Personal Author(s) : Osman, Sarah H.;Haynes, Christopher A.;Woolfitt, Adrian R.;Keppel, Theodore R.;Barr, John R.;Wang, Dongxia; Published Date : May 2026 Pages in Document : 1649-1661 (24 pdf pages) Source : ACS Infectious Diseases, 2026, v. 12, no. 5 DOI : https://doi.org/10.1021/acsinfecdis.5c01067 Journal Title : ACS Infectious Diseases
Osman, S. H., Haynes, C. A., Woolfitt, A. R., Keppel, T. R., Barr, J. R., & Wang, D. (2026). Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function. ACS Infectious Diseases, 12(5). https://doi.org/10.1021/acsinfecdis.5c01067

Osman, Sarah H., Christopher A. Haynes, Adrian R. Woolfitt, Theodore R. Keppel, John R. Barr, and Dongxia Wang. "Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function." ACS Infectious Diseases 12, no. 5 (2026). https://doi.org/10.1021/acsinfecdis.5c01067.

Osman, Sarah H., et al. "Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function." ACS Infectious Diseases, vol. 12, no. 5, 2026. Stacks. https://doi.org/10.1021/acsinfecdis.5c01067.
Export RIS Citation Information. TY - Journal Article AU - Osman, Sarah H. AU - Haynes, Christopher A. AU - Woolfitt, Adrian R. AU - Keppel, Theodore R. AU - Barr, John R. AU - Wang, Dongxia AB - The SARS-CoV-2 spike protein is heavily glycosylated. These post-translational modifications aid in interactions with human angiotensin-converting enzyme 2 (hACE2), assist in antibody evasion, and help facilitate protein dynamics. However, the exact role glycans play in maintaining the protein structure and conformation is not fully understood. In this study, we elucidated the structural function of these polysaccharides in the recombinant 614G HexaPro spike ectodomain protein by PNGase F glycosidase treatment and evaluated the subsequent effects on protein conformational dynamics via hydrogen/deuterium exchange-mass spectrometry. Our results show that enzymatic deglycosylation led to widespread conformational changes, both in regions with glycosylation sites and those without. Notably, the 630 loop, which mediates the receptor-binding domain (RBD) up/down position, became disordered, overcoming the rigidification that resulted from the D614G mutation. Additionally, heptad repeat 2, which plays a role in viral fusion machinery, also exhibited an increase in deuteration. Regions that showed a decrease in deuteration after treatment include subdomain 1, the fusion peptide proximal region, and the coiled coil. We also provide insights into the reduced thermal stability and altered binding behavior of antibodies and hACE2 in addition to changes in deuteration following enzymatic glycan removal. AB - Author manuscript AN - cdc:260682 C4 - PMC13137459 DO - https://doi.org/10.1021/acsinfecdis.5c01067 IS - 5 J2 - ACS Infectious Diseases KW - Polysaccharides KW - Glycosylation KW - Protein Conformation KW - SARS-CoV-2 KW - Spike Glycoprotein, Coronavirus KW - Humans KW - Angiotensin-Converting Enzyme 2 KW - COVID-19 KW - Protein Domains KW - Mutation KW - PNGase F KW - deglycosylation KW - glycan KW - hydrogen-deuterium exchange-mass spectrometry KW - SARS-CoV-2 KW - glycosylation KW - Spike Glycoprotein, Coronavirus KW - Glycosylation KW - SARS-CoV-2 KW - Humans KW - Protein Conformation KW - Angiotensin-Converting Enzyme 2 KW - COVID-19 KW - Polysaccharides KW - Mutation KW - Protein Domains LA - eng PY - 2026 T2 - ACS Infectious Diseases T2 - ACS Infectious Diseases, 2026, v. 12, no. 5 TI - Role of -Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function. VL - 12 UR - https://stacks.cdc.gov/view/cdc/260682 ER -

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