Colorectal cancer risk based on extended family history and body mass index

Details

• Alternative Title:
  Genet Epidemiol
• Personal Author:
  Ochs-Balcom, Heather M. ; Kanth, Priyanka ; Farnham, James M. ; Abdelrahman, Samir ; Cannon-Albright, Lisa A.
• Description:
  Family history and body mass index (BMI) are well-known risk factors for colorectal cancer (CRC), however, their joint effects are not well described. Using linked data for genealogy, self-reported height and weight from driver's licenses, and the Utah Surveillance, Epidemiology, and End-Results cancer registry, we found that an increasing number of first-degree relatives (FDR) with CRC is associated with higher standardized incidence ratio (SIR) for overweight/obese probands but not for under/normal weight probands. For probands with two CRC-affected FDRs, the SIR = 1.91 (95% CI [0.52, 4.89]) for under/normal weight probands and SIR = 4.31 (95% CI [2.46, 7.00]) for overweight/obese probands. In the absence of CRC-affected FDRs, any number of CRC-affected SDRs did not significantly increase CRC risk for under/normal weight probands, but for overweight/obese probands with at least three CRC-affected SDRs the SIR = 2.68 (95% CI [1.29, 4.93]). In the absence of CRC-affected FDRs and SDRs, any number of CRC-affected third-degree relatives (TDRs) did not increase risk in under/normal weight probands, but significantly elevated risk for overweight/obese probands with at least two CRC-affected TDRs was observed; SIR = 1.32 (95% CI [1.04, 1.65]). For nonsyndromic CRC, maximum midlife BMI affects risk based on family history and should be taken into account for CRC risk communication when possible.
• Subjects:
  Adult Aged Article Body Mass Index Cancer Screening Colorectal Cancer Colorectal Neoplasms Family Family History Humans Incidence Male Medical History Taking Middle Aged Obesity Pedigree Registries Risk Factors UPDB Utah

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• Source:
  Genet Epidemiol. 44(7):778-784
• Pubmed ID:
  32677164
• Pubmed Central ID:
  PMC7722108
• Document Type:
  Journal Article
• Funding:
  NU58DP0063200-01/CC/CDC HHSUnited States/ ; HHSN261201800016C/CA/NCI NIH HHSUnited States/ ; HHSN261201800016I/NCI SEER Program/ ; P30 CA042014/CA/NCI NIH HHSUnited States/
• Volume:
  44
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6d7e720db34a522c2150dd7d7902e5b1757d445672ea59a583ef62d3150e6c22
• Download URL:
  https://stacks.cdc.gov/view/cdc/98492/cdc_98492_DS1.pdf
• File Type:
  [PDF - 77.81 KB ]