Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Brandão-de-Resende, Camilo ; Santos, Helena Hollanda ; Rojas Lagos, Angel Alessio ; Lara, Camila Munayert ; Arruda, Jacqueline Souza Dutra ; Marino, Ana Paula Maia Peixoto ; do Valle Antonelli, Lis Ribeiro ; Gazzinelli, Ricardo Tostes ; de Almeida Vitor, Ricardo Wagner ; Vasconcelos-Santos, Daniel Vitor
• Description:
  In 2015, an outbreak of presumed waterborne toxoplasmosis occurred in Gouveia, Brazil. We conducted a 3-year prospective study on a cohort of 52 patients from this outbreak, collected clinical and multimodal imaging findings, and determined risk factors for ocular involvement. At baseline examination, 12 (23%) patients had retinochoroiditis; 4 patients had bilateral and 2 had macular lesions. Multimodal imaging revealed 2 distinct retinochoroiditis patterns: necrotizing focal retinochoroiditis and punctate retinochoroiditis. Older age, worse visual acuity, self-reported recent reduction of visual acuity, and presence of floaters were associated with retinochoroiditis. Among patients, persons >40 years of age had 5 times the risk for ocular involvement. Five patients had recurrences during follow-up, a rate of 22% per person-year. Recurrences were associated with binocular involvement. Two patients had late ocular involvement that occurred >34 months after initial diagnosis. Patients with acquired toxoplasmosis should have long-term ophthalmic follow-up, regardless of initial ocular involvement.
• Subjects:
  Aged Chorioretinitis Disease Outbreaks Humans Multimodal Imaging Prospective Studies Risk Factors Toxoplasmosis, Ocular
• Source:
  Emerg Infect Dis. 26(12):2922-2932
• Pubmed ID:
  33219657
• Pubmed Central ID:
  PMC7706934
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  26
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d7e95ee835875821ccb46a5e3ecc6b4a957dea9f982719f2b1555b1e264691e2
• Download URL:
  https://stacks.cdc.gov/view/cdc/98417/cdc_98417_DS1.pdf
• File Type:
  [PDF - 2.48 MB ]