Piloting a Clinical Laboratory Method to Evaluate the Influence of Potential Modified Risk Tobacco Products on Smokers’ Quit-Related Motivation, Choice, and Behavior

Details

• Alternative Title:
  Addict Behav
• Personal Author:
  Ozga-Hess, Jenny E. ; Felicione, Nicholas J. ; Ferguson, Stuart G. ; Dino, Geri ; Elswick, Daniel ; Whitworth, Catherine ; Turiano, Nicholas ; Blank, Melissa D.
• Description:
  Research methods are needed that can predict whether the availability of potential modified risk tobacco products (MRTPs) may influence smokers' quit-related motivation, choice, and behavior. This pilot study assessed the primary outcomes of feasibility and adherence to address this need using an electronic cigarette (ECIG) as a model MRTP. Cigarette smokers were randomly assigned to use only their own brand of cigarettes (OB-only) or a second-generation ECIG (18 ng/ml nicotine) plus their OB cigarettes (ECIG+OB) ad libitum for four weeks. Participants logged products using a mobile device, collected used cigarette filters, and provided saliva samples every day for analysis of cotinine. They returned to the lab once per week to provide a breath sample and accept or decline a choice to quit all tobacco products (i.e., cigarettes and/or ECIGs). They also returned for a one-month follow-up visit. Of those participants randomized (n = 60), 56.7% completed the 4-week intervention and 40.0% completed the follow-up visit. The primary reason for withdrawal was poor adherence with mobile device use. Comparable numbers of participants in each group chose to make a quit attempt, although more OB-only participants chose to quit during the first two weeks and more ECIG+OB participants during the last two weeks. With protocol modifications to reduce participation burden, the current method might ultimately be used by regulators to predict how smokers' quit-related motivation, choice, and behavior are influenced by current and future MRTPs.
• Subjects:
  Adult Choice Behavior Cigarette Smoking Electronic Nicotine Delivery Systems Female Humans Male Middle Aged Motivation Pilot Projects Risk Reduction Behavior Smoking Cessation Vaping

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• Keywords:
  Electronic Cigarette (ECIG) Feasibility Quit Attempt Quit Timing Smoker Tobacco
• Source:
  Addict Behav. 99:106105
• Pubmed ID:
  31470240
• Pubmed Central ID:
  PMC6791779
• Document Type:
  Journal Article
• Funding:
  T32 GM081741/GM/NIGMS NIH HHSUnited States/ ; U48 DP005004/DP/NCCDPHP CDC HHSUnited States/ ; U48DP005004/ACL/ACL HHSUnited States/ ; U54 GM104942/GM/NIGMS NIH HHSUnited States/
• Volume:
  99
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:9c3572ac062e5ef44b98a6646c9c8408ba3852d58025711caffe53d3faaefe11
• Download URL:
  https://stacks.cdc.gov/view/cdc/97972/cdc_97972_DS1.pdf
• File Type:
  [PDF - 184.19 KB ]