Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–October 3, 2020

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Zambrano, Laura D. ; Ellington, Sascha ; Strid, Penelope ; Galang, Romeo R. ; Oduyebo, Titilope ; Tong, Van T. ; Woodworth, Kate R. ; Nahabedian, John F. ; Azziz-Baumgartner, Eduardo ; Gilboa, Suzanne M. ; Meaney-Delman, Dana ; Akosa, Amanda ; Bennett, Carolyne ; Burkel, Veronica ; Chang, Daniel ; Delaney, Augustina ; Fox, Charise ; Griffin, Isabel ; Hsia, Jason ; Krause, Katie ; Lewis, Elizabeth ; Manning, Susan ; Mohamoud, Yousra ; Newton, Suzanne ; Neelam, Varsha ; Olsen, Emily O’Malley ; Perez, Mirna ; Reynolds, Megan ; Riser, Aspen ; Rivera, Maria ; Roth, Nicole M. ; Sancken, Christina ; Shinde, Neha ; Smoots, Ashley ; Snead, Margaret ; Wallace, Bailey ; Whitehill, Florence ; Whitehouse, Erin ; Zapata, Lauren
• Corporate Authors:
  CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team
• Description:
  Studies suggest that pregnant women might be at increased risk for severe illness associated with coronaVirus disease 2019 (COVID-19) (1,2). This report provides updated information about symptomatic women of reproductive age (15-44 years) with laboratory-confirmed infection with SARS-CoV-2, the Virus that causes COVID-19. During January 22-October 3, CDC received reports through national COVID-19 case Surveillance or through the National Notifiable Diseases Surveillance System (NNDSS) of 1,300,938 women aged 15-44 years with laboratory results indicative of acute infection with SARS-CoV-2. Data on pregnancy status were available for 461,825 (35.5%) women with laboratory-confirmed infection, 409,462 (88.7%) of whom were symptomatic. Among symptomatic women, 23,434 (5.7%) were reported to be pregnant. After adjusting for age, race/ethnicity, and underlying medical conditions, pregnant women were significantly more likely than were nonpregnant women to be admitted to an intensive care unit (ICU) (10.5 versus 3.9 per 1,000 cases; adjusted risk ratio [aRR] = 3.0; 95% confidence interval [CI] = 2.6-3.4), receive invasive ventilation (2.9 versus 1.1 per 1,000 cases; aRR = 2.9; 95% CI = 2.2-3.8), receive extracorporeal membrane oxygenation (ECMO) (0.7 versus 0.3 per 1,000 cases; aRR = 2.4; 95% CI = 1.5-4.0), and die (1.5 versus 1.2 per 1,000 cases; aRR = 1.7; 95% CI = 1.2-2.4). Stratifying these analyses by age and race/ethnicity highlighted disparities in risk by subgroup. Although the absolute risks for severe outcomes for women were low, pregnant women were at increased risk for severe COVID-19-associated illness. To reduce the risk for severe illness and death from COVID-19, pregnant women should be counseled about the importance of seeking prompt medical care if they have symptoms and measures to prevent SARS-CoV-2 infection should be strongly emphasized for pregnant women and their families during all medical encounters, including prenatal care visits. Understanding COVID-19-associated risks among pregnant women is important for Prevention counseling and clinical care and treatment.
• Subjects:
  Adolescent Adult BetacoronaVirus Clinical Laboratory Techniques CoronaVirus Infections COVID-19 Female Humans Laboratories Pandemics Pneumonia, Viral Pregnancy Pregnancy Complications, Infectious Risk Assessment Severity Of Illness Index Symptom Assessment Young Adult

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 69(44):1641-1647
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  33151921
• Pubmed Central ID:
  PMC7643892
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  7 pdf pages
• Volume:
  69
• Issue:
  44
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:c82d0b8956df405f83e6657a00758fd2c957bc0233a252ab965c6ebc695d631bb7876cc0c58750873f07878cf79017355308daf9898cc5b25dba48593c083785
• Download URL:
  https://stacks.cdc.gov/view/cdc/97455/cdc_97455_DS1.pdf
• File Type:
  [PDF - 124.64 KB ]