Multistate assessment of SARS-CoV-2 seroprevalence in blood donors
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Multistate assessment of SARS-CoV-2 seroprevalence in blood donors

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    • Description:
      Updated Nov. 13, 2020

      CDC is conducting a nationwide COVID-19 seroprevalence survey of blood donors to:

      • Understand the percentage of people in the United States who have antibodies against SARS-CoV-2, the virus that causes COVID-19.

      • Track how this percentage changes over time.

      This study is the largest nationwide COVID-19 seroprevalence survey to date. CDC is collaborating on this project with the National Institutes of Health (NIH), the Food and Drug Administration (FDA), Vitalant Research Institute (VRI), Westat Inc., and numerous blood collection organizations across the United States. CDC is providing technical assistance and financial support to VRI and collaborating institutions.

      Conducted under REDS-IV-P (Recipient Epidemiology and Donor Evaluation Study IV Pediatric) programexternal icon, this seroprevalence survey expands an ongoing project called the RESPONSE studyexternal icon (REDS-IV-P Epidemiology, Surveillance and Preparedness of the Novel SARS-CoV-2 Epidemic) funded by the NIH. From March to August 2020, the RESPONSE study collected existing blood donation samples from six U.S. regions (about 1000 samples per month) for testing for SARS-CoV-2 antibodies.

      The expanded seroprevalence survey includes more than 60 regions, representing all 50 states and Puerto Rico. Since July 2020, anonymous blood donation samples (about 2,000 per month) from each region are being collected and tested. The survey will continue until January 2022. A larger number of samples are being collected from blood centers in regions that encompass multiple states or are racially and ethnically diverse. Overall, about 1.5 million samples will be tested. For each region, the seroprevalence will be estimated for the region overall and by age group, sex, and race/ethnicity.

    • Content Notes:
      About this survey -- Information on blood donation samples tested -- Safety of US blood supply -- Interpreting Serology Results from This Survey.
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