Progression to hypertension in youth and young adults with type 1 or type 2 diabetes: The SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Clin Hypertens (Greenwich)
• Personal Author:
  Koebnick, Corinna ; Imperatore, Giuseppina ; Jensen, Elizabeth T. ; Stafford, Jeanette M. ; Shah, Amy S. ; Mottl, Amy K. ; Bell, Ronny A. ; Dabelea, Dana ; Liese, Angela D. ; Marcovina, Santica M. ; D’Agostino, Ralph B. ; Urbina, Elaine M. ; Lawrence, Jean M.
• Description:
  Central obesity may contribute to the development of hypertension in youths with diabetes. The SEARCH for Diabetes in Youth Study followed 1518 youths with type 1 diabetes (T1D) and 177 with type 2 diabetes (T2D) diagnosed when <20 years of age for incident hypertension. Incident hypertension was defined as blood pressure ≥95th percentile (or ≥130/80 mm Hg) or reporting antihypertensive therapy among those without hypertension at baseline. Poisson regression models were stratified by diabetes type and included demographic and clinical factors, clinical site, and waist-to-height ratio (WHtR). Youths with T2D were more likely to develop hypertension than those with T1D (35.6% vs 14.8%, P < .0001). For each 0.01 unit of annual increase in WHtR, adjusted relative risk for hypertension was 1.53 (95% CI 1.36-1.73) and 1.20 (95% CI 1.00-1.43) for youths with T1D and T2D, respectively. Effective strategies targeted toward reducing central obesity may reduce hypertension among youths with diabetes.
• Subjects:
  Adolescent Adolescents Body Mass Index Child Children Cohort Studies Diabetes Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Type 1 Diabetes Type 2 Humans Hypertension Male Obesity Original Paper Risk Factors Young Adult

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• Source:
  J Clin Hypertens (Greenwich). 22(5):888-896
• Pubmed ID:
  32297456
• Pubmed Central ID:
  PMC7383720
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000062/TR/NCATS NIH HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006138/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006133/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP006131/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; UL1 TR001450/TR/NCATS NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; UL1 TR002319/TR/NCATS NIH HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; U18 DP006134/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  22
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:60097b040ae1a81564558a139604bd64b3f2adde050554d6b1a83aefcdc4d098
• Download URL:
  https://stacks.cdc.gov/view/cdc/96942/cdc_96942_DS1.pdf
• File Type:
  [PDF - 834.76 KB ]