Details:

Alternative Title:
Environ Health
Personal Author:
Wang, Zifan ; Mínguez-Alarcón, Lidia ; Williams, Paige L. ; Bellavia, Andrea ; Ford, Jennifer B. ; ... More +
Wang, Zifan ; Mínguez-Alarcón, Lidia ; Williams, Paige L. ; Bellavia, Andrea ; Ford, Jennifer B. ; Keller, Myra ; Petrozza, John C. ; Calafat, Antonia M. ; Hauser, Russ ; James-Todd, Tamarra Less -
Description:
Background

Subfertile women have higher risk of glucose intolerance during pregnancy. Studies suggest associations between several endocrine disrupting chemicals (EDCs) and pregnancy glucose levels. However, the association between benzophenone-3 (BP-3), an EDC widely found in sunscreen, and pregnancy glucose levels remains unclear. We aimed to assess the association between perinatal exposures to BP-3 and pregnancy glucose levels in subfertile women.

Methods

We evaluated 217 women from a prospective cohort based at a fertility clinic who had urinary BP-3 concentrations measured during 3-month preconception, first and/or second trimesters, and blood glucose measured at glucose load tests (GLTs) during late pregnancy. Multivariable linear and logistic regression models were used to assess associations between time-specific BP-3 in quartiles (Q1 – Q4) and mean glucose levels, as well as odds of abnormal GLT (glucose level ≥ 140 mg/dL), adjusting for potential confounders. Effect modification was assessed by age, season, BMI, infertility diagnosis, sex of fetus (es) and physical activity.

Results

Women with higher first trimester BP-3 concentrations had lower mean glucose levels [mean glucose (95% CI) for Q4 vs Q1 = 103.4 (95.0, 112.5) vs. 114.6 (105.8, 124.2) mg/dL]. Women with higher second trimester BP-3 concentrations had lower odds of abnormal GLT [OR (95% CI) for Q3 vs. Q1 = 0.12 (0.01, 0.94)]. The associations between BP-3 and glucose levels were modified by several factors: women with female-factor infertility, urine collected during summer, older age, lower BMI, or carried female fetus (es) had the strongest inverse associations between BP-3 and glucose levels, while no associations were observed in the remaining subgroups.

Conclusions

Time-specific inverse associations between BP-3 and pregnancy glucose levels existed in subfertile women, and especially among certain subgroups of this high-risk-population.


Subject:
[+]
Adult Age Factors Benzophenone-3 Benzophenones Blood Glucose Body Mass Index Boston Endocrine Disrupting Chemicals Environmental Epidemiology Exercise Female Fertility Clinics Fetus Glucose Levels Humans Infertility Maternal Exposure Middle Aged Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Prospective Studies Research Seasons Sex Factors Young Adult
Source:
Environ Health. 19
Pubmed ID:
32345324
Pubmed Central ID:
PMC7189447
Document Type:
Journal Article
Funding:
R01 ES026166/ES/NIEHS NIH HHS/United States ; R01 ES022955/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States
R01 ES026166/ES/NIEHS NIH HHS/United States ; R01 ES022955/ES/NIEHS NIH HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:40dc61f3630d341806519d8e8041a4f8a68547e8e06e8468917ac67974c9103b
Download URL:
https://stacks.cdc.gov/view/cdc/96937/cdc_96937_DS1.pdf
File Type:

Supporting Files

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