Lack of evidence for Toxocara infection in Italian myelitis patients

Nicoletti, Alessandra; García, Hector H.; Cicero, Calogero Edoardo; Portaro, Giacomo; Giuliano, Loretta; Patti, Francesco; Sofia, Vito; Noh, John; Handali, Sukwan; Zappia, Mario

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Lack of evidence for Toxocara infection in Italian myelitis patients

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July 22 2019
By Nicoletti, Alessandra ; García, Hector H. ; Cicero, Calogero Edoardo ; ...

File Language:

English

Details

Alternative Title:

Neurol Sci
Personal Author:

Nicoletti, Alessandra ; García, Hector H. ; Cicero, Calogero Edoardo ; Portaro, Giacomo ; Giuliano, Loretta ; Patti, Francesco ; Sofia, Vito ; Noh, John ; Handali, Sukwan ; Zappia, Mario
Description:

Acute myelitis is a common neurological manifestation due to different causes, but in about 15-30% of cases its etiology remains unknown (idiopathic myelitis). Myelitis represents the most common manifestation of neurotoxocariasis, the infection of the human nervous system by larvae of the nematode Toxocara spp.; however, despite the high seroprevalence worldwide, its contribution to the burden of disease has not been assessed. We evaluated the presence of antibodies against Toxocara spp. in cerebrospinal fluid (CSF) from a sample of 28 patients with a diagnosis of idiopathic myelitis (N = 20) or encephalomyelitis (N = 8) who attended the Neurological Unit of the University Hospital of Catania, Sicily. Antibodies against Toxocara spp. were measured using a multiplex bead-based assay and Toxocara immunoblot using Toxocara canis excretory secretory antigens. All samples tested negative for the presence of anti-T. canis IgG antibodies. In this series, we found no evidence of a contribution of neurotoxocariasis to the burden of myelitis.
Subjects:

Adult Aged Animals Autoantibodies Female Humans Male Middle Aged Myelitis Retrospective Studies Toxocara Canis Toxocariasis
Source:

Neurol Sci. 41(1):239-241
Pubmed ID:

31332580
Pubmed Central ID:

PMC7646989
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHS/United States ; Piano Triennale di Sviluppo delle Attività di Ricerca Scientifica del Dipartimento 2016-18/Department G.F. Ingrassia, University of Catania/
Place as Subject:

Sicily
Volume:

41
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:ea764f3ab9969304722ff1d6dc5add3c55246f7ba26be34729a1a0ef9cfcb152
Download URL:

https://stacks.cdc.gov/view/cdc/96809/cdc_96809_DS1.pdf
File Type:

[PDF - 43.30 KB ]

nihms-1642386.nxml

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File Language:

English

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