Birth Characteristics and Risk of Early-Onset Synovial Sarcoma

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Wiemels, Joseph L. ; Wang, Rong ; Feng, Qianxi ; Clark, Cassandra J. ; Amatruda, James F. ; Rubin, Elyssa ; Yee, Amy C. ; Morimoto, Libby M. ; Metayer, Catherine ; Ma, Xiaomei
• Description:
  Background:
  
  Synovial sarcoma is a rare cancer with peak incidence in the young adult period. Despite poor outcomes of this aggressive cancer, there is little epidemiologic research addressing its etiology.
  
  Methods:
  
  We collected birth characteristic data on synovial sarcoma cases born during 1978–2015 and diagnosed during 1988–2015 in California (n = 244), and 12,200 controls frequency matched on year of birth. We also constructed a dataset of cancer cases in siblings of sarcoma subjects to assess familial risk.
  
  Results:
  
  In multivariable logistic regression analyses, synovial sarcoma was more frequent in Hispanics compared with non-Hispanic whites [OR, 1.48; 95% confidence interval (CI), 1.06–2.08]. Higher birth weight was a risk factor in Hispanics; each 500 g increase in birth weight was associated with a 22% increase in disease risk (OR, 1.22; 95% CI, 1.00–1.48). Also, a strong role for birth order was suggested, with highest risk for the first born (second child compared with first: OR, 0.61; 95% CI, 0.44–0.84; third or later compared with first: OR, 0.53; 95% CI, 0.36–0.77). Siblings of patients with synovial sarcoma did not display elevated cancer incidence, suggesting the low likelihood that strong familial predisposition alleles play a significant role in this disease.
  
  Conclusions:
  
  The associations with birth weight and birth order suggest that nutritional, developmental, and environmental factors may play a role in the etiology of synovial sarcoma.
  
  Impact:
  
  Further epidemiologic research on synovial sarcoma should evaluate epigenetic and developmental mechanisms and the formation of the archetypical t(X;18) translocation that defines this disease.
  
  
• Subjects:
  Article
• Source:
  Cancer Epidemiol Biomarkers Prev. 29(6):1162-1167
• Pubmed ID:
  32245786
• Pubmed Central ID:
  PMC7605594
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; R01 CA175737/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States
• Volume:
  29
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b1f10cbb65a4e0f15294dfe5b31e12acf8f97e63d3a5f62f7046c88f597a136d
• Download URL:
  https://stacks.cdc.gov/view/cdc/96395/cdc_96395_DS1.pdf
• File Type:
  [PDF - 338.36 KB ]