They are likely to be there: using a family-centered index testing approach to identify children living with HIV in Kenya

Details

• Alternative Title:
  Int J STD AIDS
• Personal Author:
  Okoko, Nicollate ; Kulzer, Jayne L ; Ohe, Kristen ; Mburu, Margaret ; Muttai, Hellen ; Abuogi, Lisa L ; Bukusi, Elizabeth A ; Cohen, Craig R ; Penner, Jeremy
• Description:
  In Kenya, only half of children with a parent living with HIV have been tested for HIV. The effectiveness of family-centered index testing to identify children (0-14 years) living with HIV was examined. A retrospective record review was conducted among adult index patients newly enrolled in HIV care between May and July 2015; family testing, results, and linkage to treatment outcomes were followed through May 2016 at 60 high-volume clinics in Kenya. Chi square test compared yield (percentage of HIV tests positive) among children tested through family-centered index testing, outpatient and inpatient testing. Review of 1937 index client charts led to 3005 eligible children identified for testing. Of 2848 (94.8%) children tested through family-centered index testing, 127 (4.5%) had HIV diagnosed, 100 (78.7%) were linked to care, and 85 of those eligible (91.4%) initiated antiretroviral therapy (ART).Family testing resulted in higher yield compared to inpatient (1.8%, p < 0.001) or outpatient testing (1.6%, p < 0.001). The absolute number of children living with HIV identified was highest with outpatient testing. The relative contribution of testing approach to total children identified with HIV was outpatient testing (69%), family testing (26%), and inpatient testing (5%). The family testing approach demonstrated promise in achieving the first two "90s" (identification and ART initiation) of the 90-90-90 targets for children, with additional effort required to improve linkage from testing to treatment.
• Subjects:
  Adolescent Anti-HIV Agents Child Child, Preschool Family Characteristics Female HIV Infections Humans Infant Infant, Newborn Male Mass Screening Retrospective Studies

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• Source:
  Int J STD AIDS. 31(11):1028-1033
• Pubmed ID:
  32693739
• Pubmed Central ID:
  PMC7530071
• Document Type:
  Journal Article
• Funding:
  U2G PS001913/PS/NCHHSTP CDC HHSUnited States/ ; NU2GGH001947/PEPFAR/PEPFARUnited States/
• Place as Subject:
  Kenya
• Volume:
  31
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7dd9900e64e6a3335f79feabd3803681729767cf152b3e0ecac4c0fd4cb47c94
• Download URL:
  https://stacks.cdc.gov/view/cdc/94621/cdc_94621_DS1.pdf
• File Type:
  [PDF - 144.91 KB ]