Increased pulmonary artery diameter is associated with reduced FEV1 in former World Trade Center workers

Details

• Journal Article:
  Clin Respir J
• Personal Author:
  de la Hoz, Rafael E. ; Jeon, Yunho ; Reeves, Anthony P. ; José Estépar, Raúl San ; Liu, Xiaoyu ; Doucette, John T. ; Celedón, Juan C. ; Nolan, Anna
• Description:
  Rationale: ; Occupational exposures at the WTC site after September 11, 2001 have been associated with several presumably inflammatory lower airway diseases. Pulmonary arterial enlargement, as suggested by an increased ratio of the diameter of the pulmonary artery to the diameter of the aorta (PAAr) has been reported as a computed tomographic (CT) scan marker of adverse respiratory health outcomes, including WTC-related disease. In this study, we sought to utilize a novel quantitative CT (QCT) measurement of PAAr to test the hypothesis that an increased ratio is associated with FEV1 below each subject’s statistically determined lower limit of normal (FEV1; Methods: ; In a group of 1,180 WTC workers and volunteers, we examined whether FEV1; Results: ; Unadjusted analyses showed a statistically significant association of FEV1; Conclusions: ; In WTC workers, FEV1; Trial registration: ; ClinicalTrials.gov identifier .
• Subjects:
  • Adult
  • Bronchodilator Agents
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Middle Aged
  • New York
  • Occupational Exposure
  • Pulmonary Artery
  More +
• Keywords:
  • multidetector computed tomography
  • Computer-Assisted Image Processing
  • smoke inhalation injury
  • spirometry
  • Pulmonary artery
  • Occupational Medicine
  • World Trade Center Attack
  • 2001
• Source:
  Clin Respir J. 13(10):614-623
• DOI:
  http://dx.doi.org/10.1111/crj.13067
• Pubmed ID:
  31347281
• Pubmed Central ID:
  PMC6783324
• Document Type:
  Text ; Journal Article
• Funding:
  200-2017-93325/CDC/NIOSH/ ; U01 OH011300/OH/NIOSH CDC HHSUnited States/ ; U01 OH011697/OH/NIOSH CDC HHSUnited States/ ; U01 OH010401/OH/NIOSH CDC HHSUnited States/ ; R01 HL119326/HL/NHLBI NIH HHSUnited States/
• Genre:
  Journal Article
• Volume:
  13
• Issue:
  10
• Download URL:
  https://stacks.cdc.gov/view/cdc/94469/cdc_94469_DS1.pdf
• File Type:
  [PDF - 522.13 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:57f08def9b39c8f8252264f120dd0a8997eda5eef5c969f89544c40a4872dd66e33f0ce64f5cea1c6407e44c353d117e5e89d6e1734fea968c3bf0709cb5cb49