CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Guillain-Barré syndrome and antecedent cytomegalovirus infection, United States 2009–2015
-
December 2019
-
-
Source: Neurol Sci. 41(4):885-891
[PDF-443.17 KB]
Details:
-
Alternative Title:Neurol Sci
-
Personal Author:
-
Description:Objective:
To describe incidence and clinical characteristics of cases of Guillain-Barré Syndrome (GBS) in the United States during 2009–2015, and characteristics of GBS cases with antecedent cytomegalovirus (CMV) infection among persons with employer-sponsored insurance.
Methods:
We analyzed medical claims from IBM Watson MarketScan® databases. GBS patients were defined as enrollees with an inpatient claim with GBS as the principal diagnosis code, based on ICD-9 or ICD-10, and ≥1 claim for lumbar puncture or EMG/nerve conduction study. We assessed intensive care unit (ICU) hospitalization, intubation, dysautonomia, and death. We also assessed selected infectious illness within 60 days prior to first GBS-coded inpatient claim.
Results:
We identified 3,486 GBS patients; annual incidence of 1.0–1.2/100,000 persons during 2009–2015. GBS incidence was higher in males (1.2/100,000) than females (0.9/100,000) (p=0.006) and increased with age, from 0.4/100,000 in persons 0–17 years old to 2.1/100,000 in persons ≥65 years old (p<0.001). Half of GBS patients were hospitalized in the ICU, 8% were intubated, 2% developed dysautonomia, and 1% died. Half had a claim for antecedent illness, but only 125 (3.5%) had a claim for specific infectious pathogens. The mean age among 18 GBS patients with antecedent CMV infection was 39 years versus 47 years among those without antecedent CMV infection (p=0.038).
Conclusions:
Incidence of GBS using a large national claims database was comparable to that reported in the literature, but cases appeared to be less severe. Half of GBS patients reported prior infectious illness, but only a minority had a specific pathogen identified.
-
Subjects:
-
Source:
-
Pubmed ID:31828680
-
Pubmed Central ID:PMC7501740
-
Document Type:
-
Funding:
-
Place as Subject:
-
Volume:41
-
Issue:4
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
