Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

Martines, Roosecelis B.; Ritter, Jana M.; Matkovic, Eduard; Gary, Joy; Bollweg, Brigid C.; Bullock, Hannah; Goldsmith, Cynthia S.; Silva-Flannery, Luciana; Seixas, Josilene N.; Reagan-Steiner, Sarah; Uyeki, Timothy; Denison, Amy; Bhatnagar, Julu; Shieh, Wun-Ju; Zaki, Sherif R.

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Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

Supporting Files Public Domain

2020/05/21
By Martines, Roosecelis B. ; Ritter, Jana M. ; Matkovic, Eduard ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Martines, Roosecelis B. ; Ritter, Jana M. ; Matkovic, Eduard ; Gary, Joy ; Bollweg, Brigid C. ; Bullock, Hannah ; Goldsmith, Cynthia S. ; Silva-Flannery, Luciana ; Seixas, Josilene N. ; Reagan-Steiner, Sarah ; Uyeki, Timothy ; Denison, Amy ; Bhatnagar, Julu ; Shieh, Wun-Ju ; Zaki, Sherif R.
Corporate Authors:

COVID-19 Pathology Working Group
Description:

An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection.
Subjects:

Aged Betacoronavirus Coronavirus Infections COVID-19 Female Humans Immunohistochemistry Lung Male Microscopy, Electron Middle Aged Pandemics Pneumonia, Viral
Source:

Emerg Infect Dis. 26(9):2005-2015
Pubmed ID:

32437316
Pubmed Central ID:

PMC7454055
Document Type:

Text
Genre:

Journal Article
Place as Subject:

United States
Location:

North America
Volume:

26
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha-512:aff87f39a1b905a9489ee4d1e09880c64f64a5ca816f45c31474519c9fcda0a77a5bcc867a798b3965f9bdd41fab693af17ae9815d071eaa74494b8c4a1037f7
Download URL:

https://stacks.cdc.gov/view/cdc/93027/cdc_93027_DS1.pdf
File Type:

[PDF - 6.00 MB ]

File Language:

English

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